AJP - Renal AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 275: F319-F324, 1998;
0363-6127/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsukaguchi, H.
Right arrow Articles by Hediger, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsukaguchi, H.
Right arrow Articles by Hediger, M. A.
Vol. 275, Issue 3, F319-F324, September 1998

BRIEF REVIEW
Urea transporters in kidney: molecular analysis and contribution to the urinary concentrating process1

Hiroyasu Tsukaguchi, Chairat Shayakul, Urs V. Berger, and Matthias A. Hediger

Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

Facilitated urea transporters (UTs) are responsible for urea accumulation in the renal inner medulla of the mammalian kidney and therefore play a central role in the urinary concentrating process. Recently, the cDNAs encoding three members of the UT family, UT1, UT2, and UT3 have been cloned. These transporters are expressed in different structures of the mammalian kidney. In rat, UT1 resides in the apical membrane of terminal inner medullary collecting ducts, where it mediates vasopressin-regulated urea reabsorption. UT2 and UT3 are located in descending thin limbs of Henle's loop and descending vasa recta, respectively, and participate in urinary recycling processes, which minimize urea escape from the inner medulla. UT1 and UT2 are regulated independently and respond differently to changes in dietary protein content and hydration state. Identification and characterization of these urea transporters advances our understanding of the molecular basis and regulation of the urinary concentrating mechanism.

mammalian kidney; inner medullary collecting duct; vasopressin

1 This report is the first in a series of minireviews, which are based on a symposium on the urinary concentrating mechanism, held at Experimental Biology '97 in New Orleans, LA.




This article has been cited by other articles:


Home page
 Circ. Res.Home page
J. Aitsebaomo, A. L. Portbury, J. C. Schisler, and C. Patterson
Brothers and Sisters: Molecular Insights Into Arterial-Venous Heterogeneity
Circ. Res., October 24, 2008; 103(9): 929 - 939.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Lucien, P. Bruneval, F. Lasbennes, M.-F. Belair, C. Mandet, J.-P. Cartron, P. Bailly, and M.-M. Trinh-Trang-Tan
UT-B1 urea transporter is expressed along the urinary and gastrointestinal tracts of the mouse
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R1046 - R1056.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. L. Pallone, M. R. Turner, A. Edwards, and R. L. Jamison
Countercurrent exchange in the renal medulla
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1153 - R1175.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. L. Pallone, Z. Zhang, and K. Rhinehart
Physiology of the renal medullary microcirculation
Am J Physiol Renal Physiol, February 1, 2003; 284(2): F253 - F266.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
K. Ranade, K.-D. Wu, C.-M. Hwu, C.-T. Ting, D. Pei, R. Pesich, J. Hebert, Y.-D. I. Chen, R. Pratt, R. Olshen, et al.
Genetic variation in the human urea transporter-2 is associated with variation in blood pressure
Hum. Mol. Genet., September 1, 2001; 10(19): 2157 - 2164.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Shayakul, H. Tsukaguchi, U. V. Berger, and M. A. Hediger
Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts
Am J Physiol Renal Physiol, March 1, 2001; 280(3): F487 - F494.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. Tsukaguchi, S. Weremowicz, C. C. Morton, and M. A. Hediger
Functional and molecular characterization of the human neutral solute channel aquaporin-9
Am J Physiol Renal Physiol, November 1, 1999; 277(5): F685 - F696.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. A. Knepper
Long-term regulation of urinary concentrating capacity
Am J Physiol Renal Physiol, September 1, 1998; 275(3): F332 - F333.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Combet, L. Teillet, G. Geelen, B. Pitrat, R. Gobin, S. Nielsen, M.-M. Trinh-Trang-Tan, B. Corman, and J.-M. Verbavatz
Food restriction prevents age-related polyuria by vasopressin-dependent recruitment of aquaporin-2
Am J Physiol Renal Physiol, December 1, 2001; 281(6): F1123 - F1131.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online