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Am J Physiol Renal Physiol 275: F325-F327, 1998;
0363-6127/98 $5.00
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Vol. 275, Issue 3, F325-F327, September 1998

BRIEF REVIEW
Roles of Na-K-2Cl and Na-Cl cotransporters and ROMK potassium channels in urinary concentrating mechanism1

Steven C. Hebert

Division of Nephrology, Vanderbilt University, Nashville Tennessee 37232

The cloning of the apical transport proteins involved in NaCl absorption in the thick ascending limb of Henle and the distal convoluted tubule has ushered in a new era that promises to provide molecular details of the urinary concentrating and diluting processes. We now have at hand tools to examine the regulation of these proteins that can affect the concentrating and diluting capacity.

distal convoluted tubule; Bartter's syndrome; thick ascending limb of Henle


1 This report is the second in a series of minireviews, which are based on a symposium on the urinary concentrating mechanism, held at Experimental Biology '97 in New Orleans, LA.




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