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Am J Physiol Renal Physiol 277: F487-F492, 1999;
0363-6127/99 $5.00
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Vol. 277, Issue 4, F487-F492, October 1999

BRIEF REVIEW
Glutamate transporters in kidney and brain

Matthias A. Hediger

Membrane and Biology Program and Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

Glutamate transporters play important roles in the termination of excitatory neurotransmission and in providing cells with glutamate for metabolic purposes. In the kidney, glutamate transporters are involved in reabsorption of filtered acidic amino acids, regulation of ammonia and bicarbonate production, and protection of cells against osmotic stress.

sodium-dependent transporters; intracellular pH; cell volume regulation; metabolic acidosis


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