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Am J Physiol Renal Physiol 277: F498-F500, 1999;
0363-6127/99 $5.00
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Vol. 277, Issue 4, F498-F500, October 1999

BRIEF REVIEW
Regulation of high-affinity glutamate transport by amino acid deprivation and hyperosmotic stress

J. D. McGivan1 and B. Nicholson2

1 Department of Biochemistry, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom; and 2 University of California, San Diego, Cancer Center, La Jolla, California 92093-0684

High-affinity glutamate transport activity is induced by stress in NBL-1 cells. Exposure of cells to hyperosmotic medium led to an induction of the EAAC1 glutamate transporter, preceded by a large increase in EAAC1 mRNA levels. Culture of cells in amino acid-free medium also caused a protein synthesis-dependent increase in glutamate transport activity, but this was not accompanied by an increase of either EAAC1 mRNA or protein. Indirect evidence suggests that the increase in EAAC1 activity in the latter case may be due to the synthesis of an activator protein in response to decreased intracellular glutamate concentrations.

transport; glutamate; EAAC1; cellular stress; hyperosmolarity; amino acid deprivation


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