| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Physiology and 2 Medicine, Alcalá University, Madrid; 3 Department of Pathology, Granada University, 18012 Granada; and 4 Nephrology Section, Hospital Príncipe de Asturias, 28871 Alcalá de Heuares, Madrid, Spain
Our previous studies
demonstrated an increased reactive oxygen species (ROS) production, as
well as transforming growth factor-
1 (TGF-1) expression in the
rat kidney with aging. In the present study, we examined the effect of
aging on extracellular matrix (ECM) accumulation and the effects of
treatment with angiotensin-converting enzyme inhibitors (captopril and
lisinopril) and taurine, an antioxidant amino acid. Age-related
increases in types I and IV collagen and fibronectin mRNA expression
were found at 24 and 30 mo of age. In contrast, type III collagen only
increased in 30-mo-old rats. Captopril-, lisinopril-, and
taurine-treated animals showed a statistically significant decrease in
ECM protein expression at both ages. Moreover, treatment with taurine
reduced the TGF-1 mRNA levels in 24- and 30-mo-old rats by 40%.
Taurine also completely blocked increases in type I and type IV
collagen expression in mesangial cells in response to TGF-1. Our
results demonstrate a protective role from both converting enzyme
inhibitors and taurine in the age-related progressive renal sclerosis.
In addition, taking into account that taurine is considered as an
antioxidant amino acid, present data suggest a role for ROS in
age-related progressive renal fibrosis, perhaps through
interactions with the TGF-1 pathway.
transforming growth factor-1; extracellular matrix proteins; angiotensin-converting enzyme inhibitors; reactive oxygen species; antioxidants
This article has been cited by other articles:
|
|
 |
|
  H. Jarvelainen, A. Sainio, M. Koulu, T. N. Wight, and R. Penttinen Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy Pharmacol. Rev., June 1, 2009; 61(2): 198 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, X. Chen, Q. Hong, H. Lin, H. Zhu, Q. Liu, J. Wang, Y. Xie, X. Shang, S. Shi, et al. TIMP-1 Promotes Age-Related Renal Fibrosis Through Upregulating ICAM-1 in Human TIMP-1 Transgenic Mice J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2006; 61(11): 1130 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Iacobini, G. Oddi, S. Menini, L. Amadio, C. Ricci, C. Di Pippo, M. Sorcini, F. Pricci, F. Pugliese, and G. Pugliese Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice Am J Physiol Renal Physiol, September 1, 2005; 289(3): F611 - F621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Maric, K. Sandberg, and C. Hinojosa-Laborde Glomerulosclerosis and Tubulointerstitial Fibrosis are Attenuated with 17{beta}-Estradiol in the Aging Dahl Salt Sensitive Rat J. Am. Soc. Nephrol., June 1, 2004; 15(6): 1546 - 1556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ortega-Velazquez, M. Gonzalez-Rubio, M. P. Ruiz-Torres, M. L. Diez-Marques, M. C. Iglesias, M. Rodriguez-Puyol, and D. Rodriguez-Puyol Collagen I upregulates extracellular matrix gene expression and secretion of TGF-{beta}1 by cultured human mesangial cells Am J Physiol Cell Physiol, June 1, 2004; 286(6): C1335 - C1343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Pilz and D. E. Casteel Regulation of Gene Expression by Cyclic GMP Circ. Res., November 28, 2003; 93(11): 1034 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lopez, M. T. Llinas, F. Roig, and F. J. Salazar Role of nitric oxide and cyclooxygenase-2 in regulating the renal hemodynamic response to norepinephrine Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R488 - R493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Stuart-Smith Demystified ... Nitric oxide Mol. Pathol., December 1, 2002; 55(6): 360 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Liu, J. Pittner, and A. E. G. Persson Changes of Cell Volume and Nitric Oxide Concentration in Macula Densa Cells Caused by Changes in Luminal NaCl Concentration J. Am. Soc. Nephrol., November 1, 2002; 13(11): 2688 - 2696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hocherl, M. Kammerl, F. Kees, B. K. Kramer, H. F. Grobecker, and A. Kurtz Role of renal nerves in stimulation of renin, COX-2, and nNOS in rat renal cortex during salt deficiency Am J Physiol Renal Physiol, March 1, 2002; 282(3): F478 - F484. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
