AJP - Renal AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 278: F75-F82, 2000;
0363-6127/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (53)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oliverio, M. I.
Right arrow Articles by Coffman, T. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oliverio, M. I.
Right arrow Articles by Coffman, T. M.
Vol. 278, Issue 1, F75-F82, January 2000

Abnormal water metabolism in mice lacking the type 1A receptor for ANG II

Michael I. Oliverio1, Marielle Delnomdedieu2, Christopher F. Best1, Ping Li3, Mariana Morris3, Michael F. Callahan4, G. Allan Johnson2, Oliver Smithies5, and Thomas M. Coffman1

1 Department of Medicine, 2 Center for In Vivo Microscopy, Duke University, and Veterans Affairs Medical Centers, Durham 27710; 4 Departments of Pharmacology and Physiology, Bowman Gray School of Medicine, Winston-Salem 27257; 5 Department of Pathology, University of North Carolina, Chapel Hill, North Carolina 27599; and 3 Department of Pharmacology, Wright State University, Dayton, Ohio 45401

Mice lacking AT1A receptors for ANG II have a defect in urinary concentration manifested by an inability to increase urinary osmolality to levels seen in controls after thirsting. This defect results in extreme serum hypertonicity during water deprivation. In the basal state, plasma vasopressin levels are similar in wild-type controls and Agtr1a -/- mice. Plasma vasopressin levels increase normally in the AT1A receptor-deficient mice after 24 h of water deprivation, suggesting that the defect in urine concentration is intrinsic to the kidney. Using magnetic resonance microscopy, we find that the absence of AT1A receptors is associated with a modest reduction in the distance from the kidney surface to the tip of the papilla. However, this structural abnormality seems to play little role in the urinary concentrating defect in Agtr1a -/- mice since the impairment is largely reproduced in wild-type mice by treatment with an AT1-receptor antagonist. These studies demonstrate a critical role for the AT1A receptor in maintaining inner medullary structures in the kidney and in regulating renal water excretion.

gene targeting; urinary concentration; magnetic resonance microscopy; papilla; vasopressin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Aoyagi, Y. Izumi, M. Hiroyama, T. Matsuzaki, Y. Yasuoka, A. Sanbe, H. Miyazaki, Y. Fujiwara, Y. Nakayama, Y. Kohda, et al.
Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells
Am J Physiol Renal Physiol, July 1, 2008; 295(1): F100 - F107.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
Z. Lin, Y. Chen, W. Zhang, A. F. Chen, S. Lin, and M. Morris
RNA interference shows interactions between mouse brainstem angiotensin AT1 receptors and angiotensin-converting enzyme 2
Exp Physiol, May 1, 2008; 93(5): 676 - 684.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. A. Fenton and M. A. Knepper
Mouse Models and the Urinary Concentrating Mechanism in the New Millennium
Physiol Rev, October 1, 2007; 87(4): 1083 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. Farah, K. M. Elased, and M. Morris
Genetic and dietary interactions: role of angiotensin AT1a receptors in response to a high-fructose diet
Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1083 - H1089.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Francois, C. Facemire, A. Kumar, L. Audoly, B. Koller, and T. Coffman
Role of Microsomal Prostaglandin E Synthase 1 in the Kidney
J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1466 - 1475.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. B. Wichi, V. Farah, Y. Chen, M. C. Irigoyen, and M. Morris
Deficiency in angiotensin AT1a receptors prevents diabetes-induced hypertension
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1184 - R1189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Eskild-Jensen, K. Thomsen, C. Rungo, L. S. Ferreira, L. F. Paulsen, Y. F. Rawashdeh, J. R. Nyengaard, S. Nielsen, J. C. Djurhuus, and J. Frokiaer
Glomerular and tubular function during AT1 receptor blockade in pigs with neonatal induced partial ureteropelvic obstruction
Am J Physiol Renal Physiol, March 1, 2007; 292(3): F921 - F929.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M.-Y. Chang, E. Parker, M. El Nahas, J. L. Haylor, and A. C.M. Ong
Endothelin B Receptor Blockade Accelerates Disease Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease
J. Am. Soc. Nephrol., February 1, 2007; 18(2): 560 - 569.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
N. Makhanova, M. L.S. Sequeira-Lopez, R. A. Gomez, H.-S. Kim, and O. Smithies
Disturbed Homeostasis in Sodium-Restricted Mice Heterozygous and Homozygous for Aldosterone Synthase Gene Disruption
Hypertension, December 1, 2006; 48(6): 1151 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Wang, P. J. Flannery, K. Athirakul, S. R. Dunn, W. M. Kourany, and R. F. Spurney
G{alpha}q-dependent signaling cascades stimulate water-seeking behavior
Am J Physiol Renal Physiol, October 1, 2006; 291(4): F781 - F789.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
L. J. Mullins, M. A. Bailey, and J. J. Mullins
Hypertension, Kidney, and Transgenics: A Fresh Perspective
Physiol Rev, April 1, 2006; 86(2): 709 - 746.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
Y. Chen, H. Chen, A. Hoffmann, D. R. Cool, D. I. Diz, M. C. Chappell, A. Chen, and M. Morris
Adenovirus-Mediated Small-Interference RNA for In Vivo Silencing of Angiotensin AT1a Receptors in Mouse Brain
Hypertension, February 1, 2006; 47(2): 230 - 237.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Lee, Z. Wu, K. Sandberg, S-E. Yoo, and C. Maric
Posttranscriptional mechanisms contribute to osmotic regulation of ANG type 1 receptors in cultured rat renomedullary interstitial cells
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R44 - R49.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Makhanova, G. Lee, N. Takahashi, M. L. Sequeira Lopez, R. A. Gomez, H.-S. Kim, and O. Smithies
Kidney function in mice lacking aldosterone
Am J Physiol Renal Physiol, January 1, 2006; 290(1): F61 - F69.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. M. Elased, D. R. Cool, and M. Morris
Novel Mass Spectrometric Methods for Evaluation of Plasma Angiotensin Converting Enzyme 1 and Renin Activity
Hypertension, October 1, 2005; 46(4): 953 - 959.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
Y. Chen, H. Chen, and M. Morris
Enhanced osmotic responsiveness in angiotensin AT1a receptor deficient mice: evidence for a role for AT1b receptors
Exp Physiol, September 1, 2005; 90(5): 739 - 746.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T.-H. Kwon, J. Nielsen, M. A. Knepper, J. Frokiaer, and S. Nielsen
Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats
Am J Physiol Renal Physiol, April 1, 2005; 288(4): F673 - F684.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Chen, L. F. Joaquim, V. M. Farah, R. B. Wichi, R. Fazan Jr., H. C. Salgado, and M. Morris
Cardiovascular autonomic control in mice lacking angiotensin AT1a receptors
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R1071 - R1077.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
N. Takahashi, M. L. S. S. Lopez, J. E. Cowhig Jr., M. A. Taylor, T. Hatada, E. Riggs, G. Lee, R. A. Gomez, H.-S. Kim, and O. Smithies
Ren1c Homozygous Null Mice Are Hypotensive and Polyuric, but Heterozygotes Are Indistinguishable from Wild-Type
J. Am. Soc. Nephrol., January 1, 2005; 16(1): 125 - 132.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
T. H. Le, M. I. Oliverio, H.-S. Kim, H. Salzler, R. C. Dash, D. N. Howell, O. Smithies, S. Bronson, and T. M. Coffman
A {gamma}GT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice
Physiol Genomics, August 11, 2004; 18(3): 290 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
Y. Zhou, Y. Chen, W. P. Dirksen, M. Morris, and M. Periasamy
AT1b Receptor Predominantly Mediates Contractions in Major Mouse Blood Vessels
Circ. Res., November 28, 2003; 93(11): 1089 - 1094.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. L. Davisson
Physiological genomic analysis of the brain renin-angiotensin system
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R498 - R511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. D. Bentley, M. C. Ortiz, E. L. Ritman, and J. C. Romero
The use of microcomputed tomography to study microvasculature in small rodents
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1267 - R1279.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
N. Takahashi, H. L. Brooks, J. B. Wade, W. Liu, Y. Kondo, S. Ito, M. A. Knepper, and O. Smithies
Posttranscriptional Compensation for Heterozygous Disruption of the Kidney-Specific NaK2Cl Cotransporter Gene
J. Am. Soc. Nephrol., March 1, 2002; 13(3): 604 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
L. Bankir
Antidiuretic action of vasopressin: quantitative aspects and interaction between V1a and V2 receptor-mediated effects
Cardiovasc Res, August 15, 2001; 51(3): 372 - 390.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. PRIETO, S. DIPP, S. MELEG-SMITH, and S. S. EL-DAHR
Ureteric bud derivatives express angiotensinogen and AT1 receptors
Physiol Genomics, June 6, 2001; 6(1): 29 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Morris, S. Means, M. I. Oliverio, and T. M. Coffman
Enhanced central response to dehydration in mice lacking angiotensin AT1a receptors
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1177 - R1184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Kato, J. D. Klein, C. Zhang, and J. M. Sands
Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs
Am J Physiol Renal Physiol, November 1, 2000; 279(5): F835 - F840.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
M. I. Oliverio and T. M. Coffman
Angiotensin II Receptor Physiology Using Gene Targeting
Physiology, August 1, 2000; 15(4): 171 - 175.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online