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1 Institut National de la Santé et de la Recherche Médicale U367, 75005 Paris, France; Departments of 2 Pediatrics and 3 Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2584; and 4 Department of Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan
As the transgenic and gene-targeting technology has become an invaluable experimental approach to study the function of gene products, the need has been expanded to assess the physiology in the mouse, which is virtually the only animal species to which that new genetic technology can apply. In this regard, renal physiologists have also received fruits of success from modern technology in several key areas, and areas are expanding in both depth and scope.
transgenic; gene targeting; kidney; sodium; blood pressure; micropuncture
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