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Departments of 1 Pediatrics and 2 Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75235-9063
We have recently
demonstrated that the rates of both active and passive proximal
straight tubule (PST) NaCl transport in neonatal rabbits were less than
in adults. In this segment NaCl entry across the apical membrane is via
parallel Na+/H+ and
Cl
/OH exchangers, which increases
in activity with maturation. The present in vitro microperfusion study
examined whether thyroid hormone plays a role in the maturational
increase in PST NaCl transport. Neonatal and adult PST were perfused
with a high-chloride-low bicarbonate solution without organic solutes,
simulating late proximal tubule fluid. Thyroid hormone-treated neonates
had a higher rate of PST total and passive NaCl transport. In 8-wk-old animals that were hypothyroid since birth, the maturational increase in
total and passive NaCl transport was prevented. Thyroid treatment for 4 days in hypothyroid 8-wk-old rabbits increased the rate of both total
and passive NaCl transport. The maturational increases in both
Na+/H+ and
Cl/OH exchange activities were
blunted in 8-wk-old hypothyroid animals and increased to control levels
with thyroid treatment. This study demonstrates that thyroid hormone is
a factor responsible for the maturational increase in both active and
passive PST NaCl transport.
sodium/hydrogen antiporter; chloride/base exchanger; kidney development; passive transport
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