| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-modulated enzymes protect during
acute renal failure
1 Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and John McClellan Memorial Veterans Hospital, Little Rock, Arkansas 72205; 2 Department of Pathology, Duke University Medical Center Durham, North Carolina 27710; 3 Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland 20892; and 4 Department of Geriatrics, University of Arkansas for Medical Sciences and John McClellan Memorial Veterans Hospital, Little Rock, Arkansas 72205
Regulation of fatty acid
-oxidation (FAO) represents an important mechanism for a sustained
balance of energy production/utilization in kidney tissue.
To examine the role of stimulated FAO during ischemia, Etomoxir
(Eto), clofibrate, and WY-14,643 compounds were given 5 days prior to
the induction of ischemia/reperfusion (I/R) injury. Compared
with rats administered vehicle, Eto-, clofibrate-, and WY-treated rats
had lower blood urea nitrogen and serum creatinines following I/R
injury. Histological analysis confirmed a significant amelioration of
acute tubular necrosis. I/R injury led to a threefold reduction of mRNA
and protein levels of acyl CoA oxidase (AOX) and cytochrome P4A1, as
well as twofold inhibition of their enzymatic activities. Eto treatment
prevented the reduction of mRNA and protein levels and the inhibition
of the enzymatic activities of these two peroxisome
proliferator-activated receptor-
(PPAR) target genes during I/R
injury. PPAR null mice subjected to I/R injury demonstrated
significantly enhanced cortical necrosis and worse kidney function
compared with wild-type controls. These results suggest that
upregulation of PPAR-modulated FAO genes has an important role in
the observed cytoprotection during I/R injury.
carnitine palmitoyltransferase; fatty acid oxidation; ischemia/reperfusion
This article has been cited by other articles:
|
|
 |
|
  L. Baud and E. Letavernier PPAR{alpha} Contributes to Tubular Protection J. Am. Soc. Nephrol., December 1, 2007; 18(12): 3017 - 3018. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Feldkamp, A. Kribben, N. F. Roeser, T. Ostrowski, and J. M. Weinberg Alleviation of fatty acid and hypoxia-reoxygenation-induced proximal tubule deenergization by ADP/ATP carrier inhibition and glutamate Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1606 - F1616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Korrapati, J. Chilakapati, E. A. Lock, J. R. Latendresse, A. Warbritton, and H. M. Mehendale Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice Am J Physiol Renal Physiol, August 1, 2006; 291(2): F439 - F455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Park, H. W. Kim, S. H. Ko, H. W. Chung, S. W. Lim, C. W. Yang, Y. S. Chang, A. Sugawara, Y. Guan, and M. D. Breyer Accelerated Diabetic Nephropathy in Mice Lacking the Peroxisome Proliferator-Activated Receptor {alpha}. Diabetes, April 1, 2006; 55(4): 885 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Feldkamp, A. Kribben, N. F. Roeser, R. A. Senter, and J. M. Weinberg Accumulation of nonesterified fatty acids causes the sustained energetic deficit in kidney proximal tubules after hypoxia-reoxygenation Am J Physiol Renal Physiol, February 1, 2006; 290(2): F465 - F477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Mount, R. E. Hill, S. A. Fraser, V. Levidiotis, F. Katsis, B. E. Kemp, and D. A. Power Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177 Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1103 - F1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Letavernier, J. Perez, E. Joye, A. Bellocq, B. Fouqueray, J.-P. Haymann, D. Heudes, W. Wahli, B. Desvergne, and L. Baud Peroxisome Proliferator-Activated Receptor {beta}/{delta} Exerts a Strong Protection from Ischemic Acute Renal Failure J. Am. Soc. Nephrol., August 1, 2005; 16(8): 2395 - 2402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Korrapati, E. A. Lock, and H. M. Mehendale Molecular mechanisms of enhanced renal cell division in protection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death Am J Physiol Renal Physiol, July 1, 2005; 289(1): F175 - F185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Guan Peroxisome Proliferator-Activated Receptor Family and Its Relationship to Renal Complications of the Metabolic Syndrome J. Am. Soc. Nephrol., November 1, 2004; 15(11): 2801 - 2815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Li, R. Bhatt, J. Megyesi, N. Gokden, S. V. Shah, and D. Portilla PPAR-{alpha} ligand ameliorates acute renal failure by reducing cisplatin-induced increased expression of renal endonuclease G Am J Physiol Renal Physiol, November 1, 2004; 287(5): F990 - F998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Howroyd, C. Swanson, C. Dunn, R. C. Cattley, and J. C. Corton Decreased Longevity and Enhancement of Age-Dependent Lesions in Mice Lacking the Nuclear Receptor Peroxisome Proliferator-Activated Receptor {alpha} (PPAR{alpha}) Toxicol Pathol, August 1, 2004; 32(5): 591 - 599. [Abstract] [PDF]
|
|
|
|
|
|
S. Li, P. Wu, P. Yarlagadda, N. M. Vadjunec, A. D. Proia, R. A. Harris, and D. Portilla PPAR{alpha} ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity Am J Physiol Renal Physiol, March 1, 2004; 286(3): F572 - F580. [Abstract] [Full Text]
|
|
|
|
|
|
J. V. Bonventre and J. M. Weinberg Recent Advances in the Pathophysiology of Ischemic Acute Renal Failure J. Am. Soc. Nephrol., August 1, 2003; 14(8): 2199 - 2210. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hercule and A. Oyekan Renal Cytochrome P450 Oxygenases and Preglomerular Vascular Response to Arachidonic Acid and Endothelin-1 Following Ischemia/Reperfusion J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 717 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Merrill, H. Ni, L. W. Yoon, M. A. Tirmenstein, P. Narayanan, G. R. Benavides, M. J. Easton, D. R. Creech, C. X. Hu, D. C. McFarland, et al. Etomoxir-Induced Oxidative Stress in HepG2 Cells Detected by Differential Gene Expression Is Confirmed Biochemically Toxicol. Sci., July 1, 2002; 68(1): 93 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Scholz-Pedretti, A. Gans, K.-F. Beck, J. Pfeilschifter, and M. Kaszkin Potentiation of TNF-{alpha}-Stimulated Group IIA Phospholipase A2 Expression by Peroxisome Proliferator-Activated Receptor {alpha} Activators in Rat Mesangial Cells J. Am. Soc. Nephrol., March 1, 2002; 13(3): 611 - 620. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
