ACUTE RENAL FAILURE FORUM
Acute renal failure. III. The role of growth factors in the process of renal regeneration and repair

¹ Department of Nephrology, Washington University, St. Louis, Missouri 63110; ² Department of Medicine, John L. McClellan Veterans Affairs Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; ³ Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232; ⁴ Section of Nephrology, University of Chicago, Chicago, Illinois 60637; ⁵ Department of Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109-0368; ⁶ Departments of Pediatrics and Medicine (Nephrology-Hypertension), University of California San Diego, La Jolla, California 92093-0693; and ⁷ Department of Medicine, Renal Section, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118

This review, which is the final installment in a series devoted to controversial issues in acute renal failure (ARF) (3, 47), will examine available information regarding the role of growth factors in ARF. In general, studies in this area have fallen into two broad categories: 1) those that have examined the renal expression of genes encoding growth factors or transcriptional factors associated with the growth response that is induced after ARF, and 2) those that have examined the efficacy of exogenously administered growth factors in accelerating recovery of renal function in experimental models of ARF. Despite the vast amount of information that has accumulated in these two areas of investigation, our understanding of the mechanisms involved in the process of regeneration and repair after ARF, and the role of growth factors in this response, remains rudimentary. This overview, contributed to by a number of experts in the field, is designed to summarize present knowledge and to highlight potentially fertile areas for future research in this area.

epidermal growth factor; insulin-like growth factor; hepatocyte growth factor; regeneration; early growth response genes

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