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Am J Physiol Renal Physiol 279: F289-F293, 2000;
0363-6127/00 $5.00
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Vol. 279, Issue 2, F289-F293, August 2000

Roles of ANG II and bradykinin in the renal regional blood flow responses to ACE inhibition in sodium-depleted dogs

Sophia A. Omoro1, Dewan S. A. Majid1, Samir S. El Dahr2, and L. Gabriel Navar1

Departments of 1 Physiology and of 2 Pediatrics, Tulane University School of Medicine, New Orleans, Louisianna 70112

The relative contributions of ANG II and bradykinin (BK) to the renal regional blood flow responses during angiotensin-converting enzyme (ACE) inhibition remain unclear. This study was performed to evaluate renal cortical (CBF) and medullary blood flow (MBF) responses to intrarterial administration of enalaprilat (33 µg · kg-1 · min -1) after blockade of the ANG II AT1 receptors with candesartan (100 µg) in 7 dogs fed a low-salt diet (0.01%) for 5 days. Laser-Doppler flowmetry was used to measure relative changes in CBF and MBF. Candesartan alone increased CBF (+20 ± 2%) and MBF (+22 ± 7%). Enalaprilat infusion after candesartan administration resulted in further increases in both CBF (+21 ± 5%) and MBF (+41 ± 8%). However, the relative changes in MBF were significantly greater (P < 0.01) than those in CBF. Administration of the BK B2 receptor blocker icatibant (300 µg) after enalaprilat returned CBF and MBF to values seen with candesartan alone. These data support a substantive role for BK potentiation during ACE inhibitor-induced renal vasodilation in dogs maintained on a low-sodium diet, with a relatively greater effect on MBF compared to CBF.

candesartan; icatibant; enalaprilat; laser-Doppler flowmetry; angiotensin-converting enzyme


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