AJP - Renal AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 279: F393-F399, 2000;
0363-6127/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (80)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weinman, E. J.
Right arrow Articles by Shenolikar, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weinman, E. J.
Right arrow Articles by Shenolikar, S.
Vol. 279, Issue 3, F393-F399, September 2000

INVITED REVIEW
Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA

Edward J. Weinman1, Charles Minkoff2, and Shirish Shenolikar2

1 Departments of Medicine and Physiology, University of Maryland School of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201; and 2 Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710

The activity of the sodium/hydrogen exchanger 3 (NHE3) isoform of the sodium/hydrogen exchanger in the brush-border membrane of the renal proximal tubule is tightly regulated. Recent biochemical and cellular experiments have established the essential requirement for a new class of regulatory factors, sodium/hydrogen exchanger regulatory factor (NHERF) and NHERF-like proteins, in cAMP-mediated inhibition of NHE3 activity. NHERF is the first PSD-95/Dlg/ZO-1 (PDZ) motif-containing protein localized to apical membranes and appears to facilitate cAMP-dependent protein kinase A (PKA) phosphorylation of NHE3 by interacting with the cytoskeleton to target a multiprotein complex to the brush-border membrane. Other recent experiments have indicated that NHERF also regulates the activity of other renal transport proteins, suggesting that the signal complex model of signal transduction in the kidney may be more common than presently appreciated. This article reviews studies on the regulation of NHE3 by NHERF, PKA, and ezrin and introduces the concept of regulation of renal transporters by signal complexes. Although not the primary focus of this review, recent studies have indicated a role for NHERF in membrane targeting, trafficking, and sorting of transporters, receptors, and signaling proteins. Thus NHERF and related PDZ-containing proteins appear to be essential adapters for regulation of renal transporters in the mammalian kidney that maintain salt and water balance.

ezrin; sodium/hydrogen exchanger regulatory factor; sodium/hydrogen exchanger 3; signal transduction; protein kinase A


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
B. Edemir, S. Reuter, R. Borgulya, R. Schroter, U. Neugebauer, G. Gabriels, and E. Schlatter
Acute Rejection Modulates Gene Expression in the Collecting Duct
J. Am. Soc. Nephrol., March 1, 2008; 19(3): 538 - 546.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Donowitz and X. Li
Regulatory Binding Partners and Complexes of NHE3
Physiol Rev, July 1, 2007; 87(3): 825 - 872.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Cinar, M. Chen, B. Riederer, O. Bachmann, M. Wiemann, M. Manns, O. Kocher, and U. Seidler
NHE3 inhibition by cAMP and Ca2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes
J. Physiol., June 15, 2007; 581(3): 1235 - 1246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. Capuano, D. Bacic, M. Roos, S. M. Gisler, G. Stange, J. Biber, B. Kaissling, E. J. Weinman, S. Shenolikar, C. A. Wagner, et al.
Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice
Am J Physiol Cell Physiol, February 1, 2007; 292(2): C927 - C934.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Rivera, L. De Franceschi, L. L. Peters, P. Gascard, N. Mohandas, and C. Brugnara
Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes
Am J Physiol Cell Physiol, November 1, 2006; 291(5): C880 - C886.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. K. K. Leong, A. Devillez, M. B. Sandberg, L. E. Yang, D. K. P. Yip, J. B. Klein, and A. A. McDonough
Effects of ACE inhibition on proximal tubule sodium transport
Am J Physiol Renal Physiol, April 1, 2006; 290(4): F854 - F863.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. J Weinman, R. Cunningham, J. B Wade, and S. Shenolikar
The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a
J. Physiol., August 15, 2005; 567(1): 27 - 32.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. S. Kocinsky, A. C. C. Girardi, D. Biemesderfer, T. Nguyen, S. Mentone, J. Orlowski, and P. S. Aronson
Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites
Am J Physiol Renal Physiol, August 1, 2005; 289(2): F249 - F258.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
N. Deliot, N. Hernando, Z. Horst-Liu, S. M. Gisler, P. Capuano, C. A. Wagner, D. Bacic, S. O'Brien, J. Biber, and H. Murer
Parathyroid hormone treatment induces dissociation of type IIa Na+-Pi cotransporter-Na+/H+ exchanger regulatory factor-1 complexes
Am J Physiol Cell Physiol, July 1, 2005; 289(1): C159 - C167.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
W. Lee-Kwon, J. B. Wade, Z. Zhang, T. L. Pallone, and E. J. Weinman
Expression of TRPC4 channel protein that interacts with NHERF-2 in rat descending vasa recta
Am J Physiol Cell Physiol, April 1, 2005; 288(4): C942 - C949.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
S. Shenolikar, J. W. Voltz, R. Cunningham, and E. J. Weinman
Regulation of Ion Transport by the NHERF Family of PDZ Proteins
Physiology, December 1, 2004; 19(6): 362 - 369.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Biber, S. M. Gisler, N. Hernando, C. A. Wagner, and H. Murer
PDZ interactions and proximal tubular phosphate reabsorption
Am J Physiol Renal Physiol, November 1, 2004; 287(5): F871 - F875.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. C. C. Girardi, F. Knauf, H.-U. Demuth, and P. S. Aronson
Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells
Am J Physiol Cell Physiol, November 1, 2004; 287(5): C1238 - C1245.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. Pedrosa, P. Gomes, U. Hopfer, P. A. Jose, and P. Soares-da-Silva
Gi{alpha}3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event
Am J Physiol Renal Physiol, November 1, 2004; 287(5): F1059 - F1066.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y.-S. Oh, N. W. Jo, J. W. Choi, H. S. Kim, S.-W. Seo, K.-O. Kang, J.-I. Hwang, K. Heo, S.-H. Kim, Y.-H. Kim, et al.
NHERF2 Specifically Interacts with LPA2 Receptor and Defines the Specificity and Efficiency of Receptor-Mediated Phospholipase C-{beta}3 Activation
Mol. Cell. Biol., June 1, 2004; 24(11): 5069 - 5079.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. B. Wade, J. Liu, R. A. Coleman, R. Cunningham, D. A. Steplock, W. Lee-Kwon, T. L. Pallone, S. Shenolikar, and E. J. Weinman
Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse
Am J Physiol Cell Physiol, December 1, 2003; 285(6): C1494 - C1503.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. H. Hryciw, Y. Wang, O. Devuyst, C. A. Pollock, P. Poronnik, and W. B. Guggino
Cofilin Interacts with ClC-5 and Regulates Albumin Uptake in Proximal Tubule Cell Lines
J. Biol. Chem., October 10, 2003; 278(41): 40169 - 40176.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
E. D. Lederer, S. J. Khundmiri, and E. J. Weinman
Role of NHERF-1 in Regulation of the Activity of Na-K ATPase and Sodium-Phosphate Co-transport in Epithelial Cells
J. Am. Soc. Nephrol., July 1, 2003; 14(7): 1711 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Levi
Role of PDZ Domain-Containing Proteins and ERM Proteins in Regulation of Renal Function and Dysfunction
J. Am. Soc. Nephrol., July 1, 2003; 14(7): 1949 - 1951.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Laverty, C. McWilliams, A. Sheldon, and S. S. Arnason
PTH stimulates a Cl--dependent and EIPA-sensitive current in chick proximal tubule cells in culture
Am J Physiol Renal Physiol, May 1, 2003; 284(5): F987 - F995.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
N. A. Ameen, C. Marino, and P. J. I. Salas
cAMP-dependent exocytosis and vesicle traffic regulate CFTR and fluid transport in rat jejunum in vivo
Am J Physiol Cell Physiol, February 1, 2003; 284(2): C429 - C438.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. A. Hall and R. J. Lefkowitz
Regulation of G Protein-Coupled Receptor Signaling by Scaffold Proteins
Circ. Res., October 18, 2002; 91(8): 672 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Shenolikar, J. W. Voltz, C. M. Minkoff, J. B. Wade, and E. J. Weinman
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting
PNAS, August 20, 2002; 99(17): 11470 - 11475.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Z. H. Nemeth, E. A. Deitch, Q. Lu, C. Szabo, and G. Hasko
NHE blockade inhibits chemokine production and NF-kappa B activation in immunostimulated endothelial cells
Am J Physiol Cell Physiol, August 1, 2002; 283(2): C396 - C403.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
X. Lou, T. McQuistan, R. A. Orlando, and M. G. Farquhar
GAIP, GIPC and G{alpha}i3 are Concentrated in Endocytic Compartments of Proximal Tubule Cells: Putative Role in Regulating Megalin's Function
J. Am. Soc. Nephrol., April 1, 2002; 13(4): 918 - 927.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
K. Kunzelmann and M. Mall
Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease
Physiol Rev, January 1, 2002; 82(1): 245 - 289.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. C. C. Girardi, B. C. Degray, T. Nagy, D. Biemesderfer, and P. S. Aronson
Association of Na+-H+ Exchanger Isoform NHE3 and Dipeptidyl Peptidase IV in the Renal Proximal Tubule
J. Biol. Chem., November 30, 2001; 276(49): 46671 - 46677.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. J. Weinman, C. M. Evangelista, D. Steplock, M.-Z. Liu, S. Shenolikar, and A. Bernardo
Essential Role for NHERF in cAMP-mediated Inhibition of the Na+-HCO3- Co-transporter in BSC-1 Cells
J. Biol. Chem., November 2, 2001; 276(45): 42339 - 42346.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. J. Weinman, D. Steplock, J. B. Wade, and S. Shenolikar
Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na+/H+ exchange in OK cells
Am J Physiol Renal Physiol, August 1, 2001; 281(2): F374 - F380.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Schwab
Function and spatial distribution of ion channels and transporters in cell migration
Am J Physiol Renal Physiol, May 1, 2001; 280(5): F739 - F747.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
D. Reczek and A. Bretscher
Identification of EPI64, a TBC/rabGAP Domain-containing Microvillar Protein That Binds to the First PDZ Domain of EBP50 and E3KARP
J. Cell Biol., April 2, 2001; 153(1): 191 - 206.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Shenolikar and Edward. J. Weinman
NHERF: targeting and trafficking membrane proteins
Am J Physiol Renal Physiol, March 1, 2001; 280(3): F389 - F395.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online