AJP - Renal Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 279: F525-F531, 2000;
0363-6127/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (110)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rabb, H.
Right arrow Articles by Tang, W. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rabb, H.
Right arrow Articles by Tang, W. W.
Vol. 279, Issue 3, F525-F531, September 2000

Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice

Hamid Rabb1, Frank Daniels1, Michael O'Donnell1, Mahmud Haq2, Sabiha R. Saba3, William Keane1, and Winson W. Tang4

1 Department of Internal Medicine, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota 55415; Departments of 2 Surgery and 3 Pathology, University of South Florida and Veterans Administration Hospital, Tampa, Florida 33612; and 4 Amgen, Thousand Oaks, California 91320

Mononuclear cell infiltrates are found in human renal ischemia-reperfusion injury (IRI), and peritubular T lymphocytes have been identified in experimental IRI. However, the role of T cells in the pathogenesis of renal IRI is unknown. We hypothesized that T cells are one of the important mediators of renal IRI. To test this hypothesis, we used an established mouse model of renal IRI, and evaluated mice with genetically engineered deficiency of both CD4+ and CD8+ T cells. At 48 h postischemia, CD4/CD8-knockout (KO) mice had marked improvement in renal function compared with control C57BL/6 mice (serum creatinine: 0.7 ± 0.4 vs. 2.5 ± 0.3 mg/dl, respectively; P < 0.05). Neutrophil infiltration into postischemic kidney was reduced in CD4/CD8 KO mice, compared with control mice, at both 24 h [polymorphonuclear neutrophils (PMNs)/10 high power fields: 714 ± 354 vs. 3,514 ± 660, respectively; P < 0.05] and 48 h (88 ± 32 vs. 1,979 ± 209, respectively; P < 0.05). Tubular necrosis score in CD4/CD8 KO mice, compared with control mice, was significantly less at 48 h (0.4 ± 0.1 vs. 2.4 ± 0.2, respectively; P < 0.05). Because adhesion between T cells and renal tubular epithelial cells (RTECs) may underlie the pathophysiological role of T cells in renal IRI, we also measured T cell adhesion to primary murine RTECs in vitro. Exposure of RTECs to 2 h of hypoxia followed by 1 h of reoxygenation increased T cell adhesion more than twofold. Phorbol ester treatment, which activates integrins, increased T cell adhesion threefold. These data suggest that T lymphocytes can mediate experimental renal IRI. Moreover, adhesion of infiltrating T cells to renal tubular cells may provide a potential mechanism underlying postischemic tubular dysfunction.

kidney inflammation; immune response; mouse model


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
B. Zhang, G. Ramesh, S. Uematsu, S. Akira, and W. B. Reeves
TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity
J. Am. Soc. Nephrol., May 1, 2008; 19(5): 923 - 932.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Wang, W. Brian Reeves, and G. Ramesh
Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney
Am J Physiol Renal Physiol, April 1, 2008; 294(4): F739 - F747.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. R. Pechman, D. P. Basile, H. Lund, and D. L. Mattson
Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1234 - R1239.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
D. N. Grigoryev, M. Liu, H. T. Hassoun, C. Cheadle, K. C. Barnes, and H. Rabb
The Local and Systemic Inflammatory Transcriptome after Acute Kidney Injury
J. Am. Soc. Nephrol., March 1, 2008; 19(3): 547 - 558.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Bylander, Q. Li, G. Ramesh, B. Zhang, W. B. Reeves, and J. S. Bond
Targeted disruption of the meprin metalloproteinase {beta} gene protects against renal ischemia-reperfusion injury in mice
Am J Physiol Renal Physiol, March 1, 2008; 294(3): F480 - F490.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Kim, M. Kim, N. Kim, V. D. D'Agati, C. W. Emala Sr, and H. T. Lee
Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways
Am J Physiol Renal Physiol, December 1, 2007; 293(6): F1827 - F1835.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. Hochegger, T. Schatz, P. Eller, A. Tagwerker, D. Heininger, G. Mayer, and A. R. Rosenkranz
Role of {alpha}/beta and {gamma}/{delta} T cells in renal ischemia-reperfusion injury
Am J Physiol Renal Physiol, September 1, 2007; 293(3): F741 - F747.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. T. Lee, M. Kim, M. Kim, N. Kim, F. T. Billings IV, V. D. D'Agati, and C. W. Emala Sr.
Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice
Am J Physiol Renal Physiol, September 1, 2007; 293(3): F713 - F722.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. M. Thurman, A. M. Lenderink, P. A. Royer, K. E. Coleman, J. Zhou, J. D. Lambris, R. A. Nemenoff, R. J. Quigg, and V. M. Holers
C3a Is Required for the Production of CXC Chemokines by Tubular Epithelial Cells after Renal Ishemia/Reperfusion
J. Immunol., February 1, 2007; 178(3): 1819 - 1828.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
E. Ziegler, F. Gueler, S. Rong, M. Mengel, O. Witzke, A. Kribben, H. Haller, U. Kunzendorf, and S. Krautwald
CCL19-IgG Prevents Allograft Rejection by Impairment of Immune Cell Trafficking
J. Am. Soc. Nephrol., September 1, 2006; 17(9): 2521 - 2532.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
P. Devarajan
Update on Mechanisms of Ischemic Acute Kidney Injury
J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1503 - 1520.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. R. Molls, V. Savransky, M. Liu, S. Bevans, T. Mehta, R. M. Tuder, L. S. King, and H. Rabb
Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1187 - F1193.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
P. Fiorina, M. J. Ansari, M. Jurewicz, M. Barry, V. Ricchiuti, R. N. Smith, S. Shea, T. K. Means, H. Auchincloss Jr., A. D. Luster, et al.
Role of CXC Chemokine Receptor 3 Pathway in Renal Ischemic Injury
J. Am. Soc. Nephrol., March 1, 2006; 17(3): 716 - 723.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Rabb
Immune Modulation of Acute Kidney Injury
J. Am. Soc. Nephrol., March 1, 2006; 17(3): 604 - 606.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Xu, Y. Huo, M.-C. Toufektsian, S. I. Ramos, Y. Ma, A. D. Tejani, B. A. French, and Z. Yang
Activated platelets contribute importantly to myocardial reperfusion injury
Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H692 - H699.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
E. Letavernier, J. Perez, E. Joye, A. Bellocq, B. Fouqueray, J.-P. Haymann, D. Heudes, W. Wahli, B. Desvergne, and L. Baud
Peroxisome Proliferator-Activated Receptor {beta}/{delta} Exerts a Strong Protection from Ischemic Acute Renal Failure
J. Am. Soc. Nephrol., August 1, 2005; 16(8): 2395 - 2402.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Ramesh and W. B. Reeves
p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice
Am J Physiol Renal Physiol, July 1, 2005; 289(1): F166 - F174.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. L. Karackattu, M. H. Picard, and M. Krieger
Lymphocytes Are Not Required for the Rapid Onset of Coronary Heart Disease in Scavenger Receptor Class B Type I/Apolipoprotein E Double Knockout Mice
Arterioscler. Thromb. Vasc. Biol., April 1, 2005; 25(4): 803 - 808.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. Molina, M. Ubeda, M. M. Escribese, L. Garcia-Bermejo, D. Sancho, G. P. de Lema, F. Liano, C. Cabanas, F. Sanchez-Madrid, and F. Mampaso
Renal Ischemia/Reperfusion Injury: Functional Tissue Preservation by Anti-Activated {beta}1 Integrin Therapy
J. Am. Soc. Nephrol., February 1, 2005; 16(2): 374 - 382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. K. Salahudeen
Cold ischemic injury of transplanted kidneys: new insights from experimental studies
Am J Physiol Renal Physiol, August 1, 2004; 287(2): F181 - F187.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Ardehali, H. Laks, H. Russell, M. Levine, R. Shpiner, S. Lackey, and D. Ross
Modified reperfusion and ischemia-reperfusion injury in human lung transplantation
J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1929 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. de Perrot, K. Young, Y. Imai, M. Liu, T. K. Waddell, S. Fischer, L. Zhang, and S. Keshavjee
Recipient T Cells Mediate Reperfusion Injury after Lung Transplantation in the Rat
J. Immunol., November 15, 2003; 171(10): 4995 - 5002.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Ramesh and W. B. Reeves
TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure
Am J Physiol Renal Physiol, October 1, 2003; 285(4): F610 - F618.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. V. Bonventre and J. M. Weinberg
Recent Advances in the Pathophysiology of Ischemic Acute Renal Failure
J. Am. Soc. Nephrol., August 1, 2003; 14(8): 2199 - 2210.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Yokota, M. Burne-Taney, L. Racusen, and H. Rabb
Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury
Am J Physiol Renal Physiol, August 1, 2003; 285(2): F319 - F325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. J. Burne-Taney, J. Kofler, N. Yokota, M. Weisfeldt, R. J. Traystman, and H. Rabb
Acute renal failure after whole body ischemia is characterized by inflammation and T cell-mediated injury
Am J Physiol Renal Physiol, July 1, 2003; 285(1): F87 - F94.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. J. Padanilam
Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis
Am J Physiol Renal Physiol, April 1, 2003; 284(4): F608 - F627.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. G. Ventura, T. M. Coimbra, S. B. de Campos, I. de Castro, L. Yu, and A. C. Seguro
Mycophenolate Mofetil Attenuates Renal Ischemia/Reperfusion Injury
J. Am. Soc. Nephrol., October 1, 2002; 13(10): 2524 - 2533.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. J. Burne and H. Rabb
Pathophysiological Contributions of Fucosyltransferases in Renal Ischemia Reperfusion Injury
J. Immunol., September 1, 2002; 169(5): 2648 - 2652.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. O. Leonard, K. Hannan, M. J. Burne, D. W. P. Lappin, P. Doran, P. Coleman, C. Stenson, C. T. Taylor, F. Daniels, C. Godson, et al.
15-Epi-16-(Para-Fluorophenoxy)-Lipoxin A4-Methyl Ester, a Synthetic Analogue of 15-epi-Lipoxin A4, Is Protective in Experimental Ischemic Acute Renal Failure
J. Am. Soc. Nephrol., June 1, 2002; 13(6): 1657 - 1662.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. J. Burne, A. Elghandour, M. Haq, S. R. Saba, J. Norman, T. Condon, F. Bennett, and H. Rabb
IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury
J. Leukoc. Biol., August 1, 2001; 70(2): 192 - 198.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. Park, M. Haas, P. N. Cunningham, L. Bao, J. J. Alexander, and R. J. Quigg
Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes
Am J Physiol Renal Physiol, February 1, 2002; 282(2): F352 - F357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Miyaji, X. Hu, and R. A. Star
alpha -Melanocyte-simulating hormone and interleukin-10 do not protect the kidney against mercuric chloride-induced injury
Am J Physiol Renal Physiol, May 1, 2002; 282(5): F795 - F801.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online