| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
2 Department of Pharmacology, New York Medical College, Valhalla, New York 10595; 1 Department of Medicine, University of Western Australia, Perth WA 6847, Australia; and 3 Centro de Investigacion y Estudios Avanzados Del Instituto Politécnico Nacional, Mexico City, Mexico 07000
We
studied hydroxyeicosatetraenoic acid (HETE) release in response to ANG
II from preglomerular microvessels (PGMVs), the vascular segment
governing changes in renal vascular resistance. PGMVs were isolated
from Sprague-Dawley rats and incubated with NADPH and hormones at
37°C. Eicosanoids were extracted, and cytochrome P-450
(CYP)-derived HETEs were purified and quantitated by negative chemical
ionization gas chromatography-mass spectroscopy. PGMVs produced
primarily 20- and 19-HETEs, namely, 7.9 ± 1.7 and 2.2 ± 0.5 ng/mg protein, respectively. ANG II (5 nM) increased CYP-HETE release
by two- to threefold; bradykinin, phenylephrine, and Ca2+
ionophore were without effect. [Sar1]ANG II (0.1-100
µM) dose dependently stimulated 19- and 20-HETEs, an effect blocked
by the AT2-receptor antagonist PD-123319 as well as by
U-73122, a phospholipase C inhibitor. Microvascular 20-HETE release was
increased more than twofold by the third day in response to ANG II (120 ng · kg
1 · min1) infused
subcutaneously for 2 wk; it was not further enhanced after 14 days,
although blood pressure continued to rise. Thus an
AT2-phospholipse C effector unit is associated with
synthesis of a vasoconstrictor product, 20-HETE, in a key renovascular segment.
kidney; arachidonic acid metabolism; angiotensin II receptors; arteries; gas chromatography-mass spectroscopy
This article has been cited by other articles:
|
|
 |
|
  M. W. Buczynski, D. S. Dumlao, and E. A. Dennis Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology J. Lipid Res., June 1, 2009; 50(6): 1015 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sun, W. Liu, D.-H. Lin, P. Yue, R. Kemp, L. M. Satlin, and W.-H. Wang Epoxyeicosatrienoic Acid Activates BK Channels in the Cortical Collecting Duct J. Am. Soc. Nephrol., March 1, 2009; 20(3): 513 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Nayeem, S. M. Poloyac, J. R. Falck, D. C. Zeldin, C. Ledent, D. S. Ponnoth, H. R. Ansari, and S. J. Mustafa Role of CYP epoxygenases in A2AAR-mediated relaxation using A2AAR-null and wild-type mice Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H2068 - H2078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Minuz, H. Jiang, C. Fava, L. Turolo, S. Tacconelli, M. Ricci, P. Patrignani, A. Morganti, A. Lechi, and J. C. McGiff Altered Release of Cytochrome P450 Metabolites of Arachidonic Acid in Renovascular Disease Hypertension, May 1, 2008; 51(5): 1379 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cheng, J.-S. Ou, H. Singh, J. R. Falck, D. Narsimhaswamy, K. A. Pritchard Jr., and M. L. Schwartzman 20-Hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H1018 - H1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Marvar, J. R. Falck, and M. A. Boegehold High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1507 - H1515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Magnusson, C. M. Sorensen, T. H. Braunstein, N.-H. Holstein-Rathlou, and M. Salomonsson Renovascular BKCa channels are not activated in vivo under resting conditions and during agonist stimulation Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R345 - R353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sun, D.-H. Lin, T. Wang, E. Babilonia, Z. Wang, Y. Jin, R. Kemp, A. Nasjletti, and W.-H. Wang Low Na intake suppresses expression of CYP2C23 and arachidonic acid-induced inhibition of ENaC Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1192 - F1200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Joly, R. Seqqat, B. Flamion, N. Caron, A. Michel, J. D. Imig, and R. Kramp Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R977 - R986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Jacobs, D. Zhu, S. Gruenloh, B. Lopez, and M. Medhora VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L369 - L377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Carroll, A. B. Doumad, J. Li, M. K. Cheng, J. R. Falck, and J. C. McGiff Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway Am J Physiol Renal Physiol, July 1, 2006; 291(1): F155 - F161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yaghi and S. M. Sims Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1061 - L1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sarkis, O. Ito, T. Mori, M. Kohzuki, S. Ito, J. Verbalis, A. W. Cowley Jr., and R. J. Roman Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1333 - F1340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Liclican, J. C. McGiff, P. L. Pedraza, N. R. Ferreri, J. R. Falck, and M. A. Carroll Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids Am J Physiol Renal Physiol, August 1, 2005; 289(2): F386 - F392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. O. Oyekan Differential Effects of 20-Hydroxyeicosatetraenoic Acid on Intrarenal Blood Flow in the Rat J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1289 - 1295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, R. J. Roman, J. R. Falck, L. de la Cruz, and J. H. Lombard Effects of high-salt diet on CYP450-4A {omega}-hydroxylase expression and active tone in mesenteric resistance arteries Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1557 - H1565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Vera, M. Taylor, Q. Bohman, A. Flasch, R. J. Roman, and D. E. Stec Fenofibrate Prevents the Development of Angiotensin II-Dependent Hypertension in Mice Hypertension, April 1, 2005; 45(4): 730 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Zhang, H. Deng, R. Kemp, H. Singh, V. R. Gopal, J. R. Falck, M. Laniado-Schwartzman, and A. Nasjletti Decreased Levels of Cytochrome P450 2E1-Derived Eicosanoids Sensitize Renal Arteries to Constrictor Agonists in Spontaneously Hypertensive Rats Hypertension, January 1, 2005; 45(1): 103 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wei, D.-H. Lin, R. Kemp, G. S.S. Yaddanapudi, A. Nasjletti, J. R. Falck, and W.-H. Wang Arachidonic Acid Inhibits Epithelial Na Channel Via Cytochrome P450 (CYP) Epoxygenase-dependent Metabolic Pathways J. Gen. Physiol., November 29, 2004; 124(6): 719 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Zhang, M.-H. Wang, J.-S. Wang, B. Zand, V. R. Gopal, J. R. Falck, M. Laniado-Schwartzman, and A. Nasjletti Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1089 - H1095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-I. Kaide, F. Zhang, Y. Wei, W. Wang, V. R. Gopal, J. R. Falck, M. Laniado-Schwartzman, and A. Nasjletti Vascular CO Counterbalances the Sensitizing Influence of 20-HETE on Agonist-Induced Vasoconstriction Hypertension, August 1, 2004; 44(2): 210 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Dos Santos, A. J. Dahly-Vernon, K. M. Hoagland, and R. J. Roman Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R58 - R68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Llinas, B. T. Alexander, M. F. Capparelli, M. A. Carroll, and J. P. Granger Cytochrome P-450 Inhibition Attenuates Hypertension Induced by Reductions in Uterine Perfusion Pressure in Pregnant Rats Hypertension, March 1, 2004; 43(3): 623 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rivera, N. Ward, J. Hodgson, I. B. Puddey, J. R. Falck, and K. D. Croft Measurement of 20-Hydroxyeicosatetraenoic Acid in Human Urine by Gas Chromatography-Mass Spectrometry Clin. Chem., January 1, 2004; 50(1): 224 - 226. [Full Text] [PDF]
|
|
|
|
|
|
S. L. Amaral, K. G. Maier, D. N. Schippers, R. J. Roman, and A. S. Greene CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1528 - H1535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Cheng, J. C. McGiff, and M. A. Carroll Renal arterial 20-hydroxyeicosatetraenoic acid levels: regulation by cyclooxygenase Am J Physiol Renal Physiol, March 1, 2003; 284(3): F474 - F479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alonso-Galicia, K. G. Maier, A. S. Greene, A. W. Cowley Jr., and R. J. Roman Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R60 - R68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Wang, B. A. Zand, A. Nasjletti, and M. Laniado-Schwartzman Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R383 - R389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Roman P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function Physiol Rev, January 1, 2002; 82(1): 131 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Fleming Cytochrome P450 and Vascular Homeostasis Circ. Res., October 26, 2001; 89(9): 753 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Huang, D. Sun, M. A. Carroll, H. Jiang, C. J. Smith, J. A. Connetta, J. R. Falck, E. G. Shesely, A. Koller, and G. Kaley EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2462 - H2469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. I. Pomposiello, M. A. Carroll, J. R. Falck, and J. C. McGiff Epoxyeicosatrienoic Acid-Mediated Renal Vasodilation to Arachidonic Acid Is Enhanced in SHR Hypertension, March 1, 2001; 37(3): 887 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kehl, L. Cambj-Sapunar, K. G. Maier, N. Miyata, S. Kametani, H. Okamoto, A. G. Hudetz, M. L. Schulte, D. Zagorac, D. R. Harder, et al. 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1556 - H1565. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
