AJP - Renal Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 279: F1101-F1109, 2000;
0363-6127/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jonassen, T. E. N.
Right arrow Articles by Nielsen, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jonassen, T. E. N.
Right arrow Articles by Nielsen, S.
Vol. 279, Issue 6, F1101-F1109, December 2000

Renal water handling in rats with decompensated liver cirrhosis

Thomas E. N. Jonassen1, Sten Christensen1, Tae-Hwan Kwon2, Susanna Langhoff1, Nanna Salling1, and Søren Nielsen2

1 Department of Pharmacology, the Panum Institute, University of Copenhagen, 2200 Copenhagen N; and the 2 Department of Cell Biology, Institute of Anatomy, University of Arhus, Arhus DK-8000, Denmark

The present study was performed to investigate the renal handling of water in rats with decompensated liver cirrhosis. Liver cirrhosis was induced by intraperitoneal administration of carbon tetrachloride twice weekly for 16 wk. Control rats were treated with vehicle. The cirrhotic rats developed severe disturbances in water homeostasis: urine production was decreased and hyperosmotic, the rats had significantly decreased plasma sodium concentration and ascites, and the ability to excrete an intravenous water load was significantly impaired. Plasma concentrations of vasopressin and aldosterone were increased. Mean arterial pressure, glomerular filtration rate (GFR), and fractional lithium excretion were decreased. Acute vasopressin type 2-receptor blockade with the selective nonpeptide antagonist OPC-31260 (800 µg · kg-1 · h-1) was performed during conditions whereby volume depletion was prevented by computer-driven, servo-controlled intravenous volume replacement with 150 mM glucose. The aquaretic response to OPC-31260 was similar in cirrhotic and control rats. However, the OPC 31260-induced rises in fractional water excretion (Delta V/GFR; +24%) and fractional distal water excretion (Delta V/CLi; +46%) were significantly increased in the cirrhotic rats, where V is flow rate and Delta  is change. This suggests that vasopressin-mediated renal water reabsorption capacity was increased in the cirrhotic rats. Semiquantitative immunoblotting revealed that the expression of the vasopressin-regulated water channel aquaporin-2 was unchanged in membrane fractions of both whole kidney and inner medulla from cirrhotic rats. Together, these results suggest a relative escape from vasopressin on collecting duct water reabsorption in rats with decompensated liver cirrhosis.

aquaporin-2; OPC-31260; collecting ducts; carbon tetrachloride; vasopressin type 2 receptor


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
U. S. K. van Deurs, N. Hadrup, J. S. Petersen, S. Christensen, and T. E. N. Jonassen
Nociceptin/Orphanin FQ Peptide Receptor Agonist Ac-RYYRWKKKKKKK-NH2 (ZP120) Induces Antinatriuresis in Rats by Stimulation of Amiloride-Sensitive Sodium Reabsorption
J. Pharmacol. Exp. Ther., February 1, 2009; 328(2): 533 - 539.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
N. Hadrup, J. S. Petersen, S. Windfeld, L. Risom, C. B. Andersen, S. Nielsen, S. Christensen, and T. E. N. Jonassen
Differential Down-Regulation of Aquaporin-2 in Rat Kidney Zones by Peripheral Nociceptin/Orphanin FQ Receptor Agonism and Vasopressin Type-2 Receptor Antagonism
J. Pharmacol. Exp. Ther., November 1, 2007; 323(2): 516 - 524.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. W. Kim, U. K. Schou, C. D. Peters, S. de Seigneux, T.-H. Kwon, M. A. Knepper, T. E.N. Jonassen, J. Froki, and S. Nielsen
Increased Apical Targeting of Renal Epithelial Sodium Channel Subunits and Decreased Expression of Type 2 11{beta}-Hydroxysteroid Dehydrogenase in Rats with CCl4-Induced Decompensated Liver Cirrhosis
J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3196 - 3210.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Brond, N. Hadrup, N. Salling, M. Torp, M. Graebe, S. Christensen, S. Nielsen, and T. E. N. Jonassen
Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis
Am J Physiol Renal Physiol, October 1, 2004; 287(4): F806 - F815.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Hadrup, J. S. Petersen, J. Praetorius, E. Meier, M. Graebe, L. Brond, D. Staahltoft, S. Nielsen, S. Christensen, D. R. Kapusta, et al.
Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation
Am J Physiol Renal Physiol, July 1, 2004; 287(1): F160 - F168.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. E. N. Jonassen, M. Grabe, D. Promeneur, S. Nielsen, S. Christensen, and N. V. Olsen
Lipopolysaccharide-Induced Acute Renal Failure in Conscious Rats: Effects of Specific Phosphodiesterase Type 3 and 4 Inhibition
J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 364 - 374.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Staahltoft, S. Nielsen, N. R. Janjua, S. Christensen, O. Skott, N. Marcussen, and T. E. N. Jonassen
Losartan treatment normalizes renal sodium and water handling in rats with mild congestive heart failure
Am J Physiol Renal Physiol, February 1, 2002; 282(2): F307 - F315.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online