| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Institut für 1 Physiologie I and 4 Pharmakologie, Universität Regensburg, D-93040 Regensburg; 2 Nephrologie/Medicine Klinik IV, Universität Erlangen-Nürnberg, D-91054 Erlangen; 3 IMB, Afdeling for Fysiologi, DK-5000 Odense C; 6 Institut für Pharmakologie, Universität Regensburg, D-93040 Regensburg and 5 Innere Medicine II, Universitätsklinikum Regensburg, D-93053 Regensburg
This
study aimed to characterize the influence of acute renal artery
stenosis on cyclooxygenase-2 (COX-2) and renin expression in the
juxtaglomerular apparatus. For this purpose, male Sprague-Dawley rats
received a left renal artery clip, and COX-2 mRNA, COX-2 immunoreactivity, plasma renin activity, and renin mRNA levels were
determined. COX-2 mRNA and COX-2 immunoreactivity in the macula densa
region in the clipped kidneys increased as early as 6 h after
clipping and reached a maximal expression 1-2 days after clipping.
Although values for plasma renin activity were elevated markedly at all
time points examined, remaining renin mRNA levels were unchanged after
6 h and then increased to reach a maximum value 1-2 days
after clipping. In the contralateral intact kidney, renin mRNA and
COX-2 immunoreactivity decreased to ~50% of their normal values. To
investigate a possible causal relationship between the changes of COX-2
and of renin expression, clipped rats were treated with the COX-2
blocker celecoxib (40 mg · kg
1 · day1). This
treatment, however, did not change renin mRNA either in the clipped or
in the contralateral intact kidney. Our findings indicate that renal
artery stenosis causes ipsilaterally an acute upregulation and
contralaterally a downregulation of juxtaglomerular COX-2 expression.
The lacking effect of celecoxib on renin gene expression does not
support the concept of a direct mediator function of COX-2-derived
prostaglandins in the control of renin expression during renal hypoperfusion.
cycoloxygenase-1; cyclooxygenase-2; juxtaglomerular apparatus; renin ; prostaglandins; celecoxib
This article has been cited by other articles:
|
|
 |
|
  C. S. Wilcox and A. Pearlman Chemistry and Antihypertensive Effects of Tempol and Other Nitroxides Pharmacol. Rev., December 1, 2008; 60(4): 418 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Bivol, M. Hultstrom, O. A. Gudbrandsen, R. K. Berge, and B. M. Iversen Tetradecylthioacetic acid downregulates cyclooxygenase 2 in the renal cortex of two-kidney, one-clip hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1866 - R1873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Jaimes, M.-S. Zhou, D. D. Pearse, L. Puzis, and L. Raij Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species Am J Physiol Renal Physiol, February 1, 2008; 294(2): F385 - F392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Matzdorf, A. Kurtz, and K. Hocherl COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneys Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1782 - F1790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Wagner, C. de Wit, L. Kurtz, C. Grunberger, A. Kurtz, and F. Schweda Connexin40 Is Essential for the Pressure Control of Renin Synthesis and Secretion Circ. Res., March 2, 2007; 100(4): 556 - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Linz, K. Amann, W. Freisinger, T. Ditting, K. F. Hilgers, and R. Veelken Sensory Neurons With Afferents From Hind Limbs: Enhanced Sensitivity in Secondary Hypertension Hypertension, March 1, 2006; 47(3): 527 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Schweda, F. Segerer, H. Castrop, J. Schnermann, and A. Kurtz Blood Pressure-Dependent Inhibition of Renin Secretion Requires A1 Adenosine Receptors Hypertension, October 1, 2005; 46(4): 780 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Norregaard, B. L. Jensen, C. Li, W. Wang, M. A. Knepper, S. Nielsen, and J. Frokiaer COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction Am J Physiol Renal Physiol, August 1, 2005; 289(2): F322 - F333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Schweda, M. Kammerl, C. Wagner, B. K. Kramer, and A. Kurtz Upregulation of macula densa cyclooxygenase-2 expression is not dependent on glomerular filtration Am J Physiol Renal Physiol, July 1, 2004; 287(1): F95 - F101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Mertz, J. Liu, N. K. Valego, S. P. Stallings, J. P. Figueroa, and J. C. Rose Inhibition of cyclooxygenase-2: effects on renin secretion and expression in fetal lambs Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1012 - R1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hartner, N. Cordasic, M. Goppelt-Struebe, R. Veelken, and K. F. Hilgers Role of macula densa cyclooxygenase-2 in renovascular hypertension Am J Physiol Renal Physiol, March 1, 2003; 284(3): F498 - F502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Castrop, J. Klar, C. Wagner, K. Hocherl, and A. Kurtz General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system Am J Physiol Renal Physiol, March 1, 2003; 284(3): F518 - F524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hocherl, F. Dreher, H. Vitzthum, J. Kohler, and A. Kurtz Cyclosporine A Suppresses Cyclooxygenase-2 Expression in the Rat Kidney J. Am. Soc. Nephrol., October 1, 2002; 13(10): 2427 - 2436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hocherl, M. C. Kammerl, K. Schumacher, D. Endemann, H. F. Grobecker, and A. Kurtz Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake Am J Physiol Renal Physiol, August 1, 2002; 283(2): F294 - F301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Beierwaltes Cyclooxygenase-2 products compensate for inhibition of nitric oxide regulation of renal perfusion Am J Physiol Renal Physiol, July 1, 2002; 283(1): F68 - F72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hocherl, M. Kammerl, F. Kees, B. K. Kramer, H. F. Grobecker, and A. Kurtz Role of renal nerves in stimulation of renin, COX-2, and nNOS in rat renal cortex during salt deficiency Am J Physiol Renal Physiol, March 1, 2002; 282(3): F478 - F484. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
