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Am J Physiol Renal Physiol 280: F748-F757, 2001;
0363-6127/01 $5.00
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Vol. 280, Issue 5, F748-F757, May 2001

INVITED REVIEW
Ion permeation and selectivity in ClC-type chloride channels

Christoph Fahlke

Institute of Physiology, RWTH Aachen, 52057 Aachen, Germany, and Centro de Estudios Cientificos, Valdivia, Chile

Voltage-gated anion channels are present in almost every living cell and have many physiological functions. Recently, a novel gene family encoding voltage-gated chloride channels, the ClC family, was identified. The knowledge of primary amino acid sequences has allowed for the study of these anion channels in heterologous expression systems and made possible the combination of site-directed mutagenesis and high-resolution electrophysiological measurements as a means of gaining insights into the molecular basis of channel function. This review focuses on one particular aspect of chloride channel function, the selective transport of anions through biological membranes. I will describe recent experiments using a combination of cellular electrophysiology, molecular genetics, and recombinant DNA technology to study the molecular basis of ion permeation and selection in ClC-type chloride channels. These novel tools have provided new insights into basic mechanisms underlying the function of these biologically important channels.

voltage-gated chloride channels


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