AJP - Renal Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 281: F38-F47, 2001;
0363-6127/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (75)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Quiroz, Y.
Right arrow Articles by Rodríguez-Iturbe, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quiroz, Y.
Right arrow Articles by Rodríguez-Iturbe, B.
Vol. 281, Issue 1, F38-F47, July 2001

Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition

Yasmir Quiroz1, Héctor Pons1, Katherine L. Gordon2, Jaimar Rincón1, Maribel Chávez1, Gustavo Parra1, Jaime Herrera-Acosta3, Dulcenombre Gómez-Garre4, Raquel Largo4, Jesus Egido4, Richard J. Johnson2, and Bernardo Rodríguez-Iturbe1

1 Renal Service and Department of Immunobiology (INBIOMED), Hospital Universitario de la Universidad del Zulia, Maracaibo 4001-A, Venezuela; 2 Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030; 3 Nephrology Department, Instituto Nacional de Cardiología, Mexico City 4080, Mexico; and 4 Laboratorio de Nefrología, Fundación Jiménez Díaz, Autómona University, Madrid 28040, Spain

Recent studies have suggested that subtle microvascular and tubulointerstitial injury in the kidney can cause salt-sensitive hypertension. To test this hypothesis, we determined whether the mild renal disease induced by transient blockade of nitric oxide (NO) synthesis would result in salt-sensitive hypertension and whether prevention of the renal injury by coadministration of the immunosuppressive agent mycophenolate mofetil (MMF) would block the development of salt sensitivity. Nomega -nitro-L-arginine-methyl ester (L-NAME; 70 mg/100 ml in the drinking water) was administered for 3 wk to rats with or without MMF (30 mg · kg-1 · day-1 by gastric gavage), followed by a 1-wk "washout" period in which the MMF was continued, which was followed in turn by placement on a high-salt (4% NaCl) diet for an additional 4 wk. Renal histology was examined at 3 and 8 wk, and blood pressure was measured serially. L-NAME treatment resulted in acute hypertension and the development of mild renal injury. During the washout period, blood pressure returned to normal, only to return to the hypertensive range on exposure of the animals to a high-salt diet. MMF treatment prevented the development of hypertension in response to a high-salt diet. This correlated with the ability of MMF to inhibit specific aspects of the renal injury, including the development of segmental glomerulosclerosis, the infiltration of T cells and ANG II-positive cells, and the thickening of afferent arterioles.

lymphocytes; nitric oxide inhibition; angiotensin II-positive cells


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
T. Kosugi, M. Heinig, T. Nakayama, T. Connor, Y. Yuzawa, Q. Li, W. W. Hauswirth, M. B. Grant, B. P. Croker, M. Campbell-Thompson, et al.
Lowering Blood Pressure Blocks Mesangiolysis and Mesangial Nodules, but Not Tubulointerstitial Injury, in Diabetic eNOS Knockout Mice
Am. J. Pathol., April 1, 2009; 174(4): 1221 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
D. I. Feig, D.-H. Kang, and R. J. Johnson
Uric Acid and Cardiovascular Risk
N. Engl. J. Med., October 23, 2008; 359(17): 1811 - 1821.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Quiroz, A. Ferrebuz, F. Romero, N. D. Vaziri, and B. Rodriguez-Iturbe
Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction
Am J Physiol Renal Physiol, February 1, 2008; 294(2): F336 - F344.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. L. Graciano, A. Nishiyama, K. Jackson, D. M. Seth, R. M. Ortiz, M. C. Prieto-Carrasquero, H. Kobori, and L. G. Navar
Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F161 - F169.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. J Johnson, M. S Segal, Y. Sautin, T. Nakagawa, D. I Feig, D.-H. Kang, M. S Gersch, S. Benner, and L. G Sanchez-Lozada
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
Am. J. Clinical Nutrition, October 1, 2007; 86(4): 899 - 906.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Bravo, Y. Quiroz, A. Ferrebuz, N. D. Vaziri, and B. Rodriguez-Iturbe
Mycophenolate mofetil administration reduces renal inflammation, oxidative stress, and arterial pressure in rats with lead-induced hypertension
Am J Physiol Renal Physiol, August 1, 2007; 293(2): F616 - F623.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Franco, F. Martinez, Y. Quiroz, O. Galicia, R. Bautista, R. J. Johnson, and B. Rodriguez-Iturbe
Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R251 - R256.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. R. Spurgeon-Pechman, D. L. Donohoe, D. L. Mattson, H. Lund, L. James, and D. P. Basile
Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium
Am J Physiol Renal Physiol, July 1, 2007; 293(1): F269 - F278.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. G. Sanchez-Lozada, E. Tapia, R. Lopez-Molina, T. Nepomuceno, V. Soto, C. Avila-Casado, T. Nakagawa, R. J. Johnson, J. Herrera-Acosta, and M. Franco
Effects of acute and chronic L-arginine treatment in experimental hyperuricemia
Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1238 - F1244.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. Nakagawa, W. Sato, O. Glushakova, M. Heinig, T. Clarke, M. Campbell-Thompson, Y. Yuzawa, M. A. Atkinson, R. J. Johnson, and B. Croker
Diabetic Endothelial Nitric Oxide Synthase Knockout Mice Develop Advanced Diabetic Nephropathy
J. Am. Soc. Nephrol., February 1, 2007; 18(2): 539 - 550.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Rodriguez-Iturbe, L. Sepassi, Y. Quiroz, Z. Ni, and N. D. Vaziri
Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence
J Appl Physiol, January 1, 2007; 102(1): 255 - 260.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. G. Sanchez-Lozada, E. Tapia, A. Jimenez, P. Bautista, M. Cristobal, T. Nepomuceno, V. Soto, C. Avila-Casado, T. Nakagawa, R. J. Johnson, et al.
Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats
Am J Physiol Renal Physiol, January 1, 2007; 292(1): F423 - F429.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Franco, F. Martinez, B. Rodriguez-Iturbe, R. J. Johnson, J. Santamaria, A. Montoya, T. Nepomuceno, R. Bautista, E. Tapia, and J. Herrera-Acosta
Angiotensin II, interstitial inflammation, and the pathogenesis of salt-sensitive hypertension
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1281 - F1287.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Herrera, A. Ferrebuz, E. G. MacGregor, and B. Rodriguez-Iturbe
Mycophenolate Mofetil Treatment Improves Hypertension in Patients with Psoriasis and Rheumatoid Arthritis
J. Am. Soc. Nephrol., December 1, 2006; 17(12_suppl_3): S218 - S225.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. Zoccali
Endothelial Dysfunction and the Kidney: Emerging Risk Factors for Renal Insufficiency and Cardiovascular Outcomes in Essential Hypertension.
J. Am. Soc. Nephrol., April 1, 2006; 17(4_suppl_2): S61 - S63.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. Zoccali, R. Maio, G. Tripepi, F. Mallamaci, and F. Perticone
Inflammation as a Mediator of the Link between Mild to Moderate Renal Insufficiency and Endothelial Dysfunction in Essential Hypertension.
J. Am. Soc. Nephrol., April 1, 2006; 17(4_suppl_2): S64 - S68.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. K. Fujihara, C. R. Sena, D. M. A. C. Malheiros, A. L. Mattar, and R. Zatz
Short-term nitric oxide inhibition induces progressive nephropathy after regression of initial renal injury
Am J Physiol Renal Physiol, March 1, 2006; 290(3): F632 - F640.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
B. Rodriguez-Iturbe and R. J. Johnson
Role of inflammatory cells in the kidney in the induction and maintenance of hypertension
Nephrol. Dial. Transplant., February 1, 2006; 21(2): 260 - 263.
[Full Text] [PDF]

Home page
 HypertensionHome page
R. J. Johnson, B. Rodriguez-Iturbe, T. Nakagawa, D.-H. Kang, D. I. Feig, and J. Herrera-Acosta
Subtle Renal Injury Is Likely a Common Mechanism for Salt-Sensitive Essential Hypertension
Hypertension, March 1, 2005; 45(3): 326 - 330.
[Full Text] [PDF]

Home page
 CirculationHome page
F. Perticone, R. Maio, G. Tripepi, and C. Zoccali
Endothelial Dysfunction and Mild Renal Insufficiency in Essential Hypertension
Circulation, August 17, 2004; 110(7): 821 - 825.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
R. C. Campbell
The Renin-Angiotensin System: A 21st Century Perspective
J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1963 - 1964.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. Rodriguez-Iturbe, N. D. Vaziri, J. Herrera-Acosta, and R. J. Johnson
Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all
Am J Physiol Renal Physiol, April 1, 2004; 286(4): F606 - F616.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. I. Feig and R. J. Johnson
Hyperuricemia in Childhood Primary Hypertension
Hypertension, September 1, 2003; 42(3): 247 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Nava, Y. Quiroz, N. Vaziri, and B. Rodriguez-Iturbe
Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats
Am J Physiol Renal Physiol, March 1, 2003; 284(3): F447 - F454.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. Zatz, I. L. Noronha, and C. K. Fujihara
Experimental and clinical rationale for use of MMF in nontransplant progressive nephropathies
Am J Physiol Renal Physiol, December 1, 2002; 283(6): F1167 - F1175.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Alvarez, Y. Quiroz, M. Nava, H. Pons, and B. Rodriguez-Iturbe
Overload proteinuria is followed by salt-sensitive hypertension caused by renal infiltration of immune cells
Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1132 - F1141.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. J. Johnson, J. Herrera-Acosta, G. F. Schreiner, and B. Rodriguez-Iturbe
Subtle Acquired Renal Injury as a Mechanism of Salt-Sensitive Hypertension
N. Engl. J. Med., March 21, 2002; 346(12): 913 - 923.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S.-I. Suga, M. I. Phillips, P. E. Ray, J. A. Raleigh, C. P. Vio, Y.-G. Kim, M. Mazzali, K. L. Gordon, J. Hughes, and R. J. Johnson
Hypokalemia induces renal injury and alterations in vasoactive mediators that favor salt sensitivity
Am J Physiol Renal Physiol, October 1, 2001; 281(4): F620 - F629.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. Rodriguez-Iturbe, Y. Quiroz, M. Nava, L. Bonet, M. Chavez, J. Herrera-Acosta, R. J. Johnson, and H. A. Pons
Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats
Am J Physiol Renal Physiol, February 1, 2002; 282(2): F191 - F201.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online