AJP - Renal Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 281: F478-F492, 2001;
0363-6127/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, W.
Right arrow Articles by Edwards, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, W.
Right arrow Articles by Edwards, A.
Vol. 281, Issue 3, F478-F492, September 2001

Transport of plasma proteins across vasa recta in the renal medulla

Wensheng Zhang and Aurélie Edwards

Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts 02155

In this study, we have extended a mathematical model of microvascular exchange in the renal medulla to elucidate the mechanisms by which plasma proteins are transported between vasa recta and the interstitium. In contrast with other work, a distinction was made between the paracellular pathway and the transcellular route (i.e., water channels) in descending vasa recta (DVR). Our model first indicates that concentration polarization on the interstitial side of vasa recta has a negligible effect on medullary function. Our results also suggest that, whereas proteins are cleared from the interstitium by convection, both diffusion and convection play a role in carrying proteins to the interstitium. In those regions where transcapillary oncotic pressure gradients favor volume influx through the paracellular pathway in DVR, diffusion is the only means by which proteins can penetrate the interstitium. Whether the source of interstitial protein is DVR or ascending vasa recta depends on medullary depth, vasa recta permeability to proteins, and vasa recta reflection coefficients to small solutes and proteins. Finally, our model predicts significant axial protein gradients in the renal medullary interstitium.

microcirculation; medullary interstitium; urine concentration; mathematical model


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Zhang and A. Edwards
A model of glucose transport and conversion to lactate in the renal medullary microcirculation
Am J Physiol Renal Physiol, January 1, 2006; 290(1): F87 - F102.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. T. Layton and H. E. Layton
A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. I. Formulation and base-case results
Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1346 - F1366.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Zhang and A. Edwards
Theoretical effects of UTB urea transporters in the renal medullary microcirculation
Am J Physiol Renal Physiol, October 1, 2003; 285(4): F731 - F747.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. L. Pallone, M. R. Turner, A. Edwards, and R. L. Jamison
Countercurrent exchange in the renal medulla
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1153 - R1175.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. L. Pallone, Z. Zhang, and K. Rhinehart
Physiology of the renal medullary microcirculation
Am J Physiol Renal Physiol, February 1, 2003; 284(2): F253 - F266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. Zhang and A. Edwards
Oxygen transport across vasa recta in the renal medulla
Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1042 - H1055.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online