| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Divisions of 1 Hypertension and 4 Cardiovascular Diseases, Department of Internal Medicine, 2 Department of Physiology and Biophysics, and 3 Biomathematics Resource, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905
To assess the reliability of electron beam computed tomography (EBCT), measurements of single-kidney renal blood flow (RBF), glomerular filtration rate (GFR), and intratubular contrast medium concentration (ITC) of radiographic contrast media were quantified in anesthetized pigs before and after acetylcholine-induced vasodilation and diuresis. EBCT measurements were compared with those obtained with intravascular Doppler and inulin clearance. The capability of EBCT to detect chronic changes in single-kidney function was evaluated in pigs with unilateral renal artery stenosis, and their long-term reproducibility in normal pigs was studied repeatedly at 1-mo intervals. EBCT-RBF (ml/min) correlated with Doppler-RBF as RBFEBCT = 45 + 1.07 * RBFDoppler, r = 0.81. EBCT-GFR (ml/min) correlated with inulin clearance as GFREBCT = 11.7 + 1.02 * GFRinulin, r = 0.80. During vasodilation, RBF and GFR increased, whereas ITC decreased along the nephron. In renal artery stenosis, single-kidney GFR decreased linearly with the degree of stenosis, and ITC increased along the nephron, indicating increased fluid reabsorption. EBCT-RBF, GFR, and ITC were similar among repeated measurements. This approach might be invaluable for simultaneous quantification of regional hemodynamics and function in the intact kidneys, in a manner potentially applicable to humans.
renal blood flow; glomerular filtration rate; electron beam computed tomography
This article has been cited by other articles:
|
|
 |
|
  A. R. Chade, J. D. Krier, O. Galili, A. Lerman, and L. O. Lerman Role of Renal Cortical Neovascularization in Experimental Hypercholesterolemia Hypertension, October 1, 2007; 50(4): 729 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Daghini, X.-Y. Zhu, D. Versari, M. D. Bentley, C. Napoli, A. Lerman, and L. O. Lerman Antioxidant vitamins induce angiogenesis in the normal pig kidney Am J Physiol Renal Physiol, July 1, 2007; 293(1): F371 - F381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Juillard, S. Lemoine, M. F. Janier, P. Y. Barthez, F. Bonnefoi, and M. Laville Validation of Renal Oxidative Metabolism Measurement by Positron-Emission Tomography Hypertension, July 1, 2007; 50(1): 242 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Daghini, A. N. Primak, A. R. Chade, J. D. Krier, X.-Y. Zhu, E. L. Ritman, C. H. McCollough, and L. O. Lerman Assessment of Renal Hemodynamics and Function in Pigs with 64-Section Multidetector CT: Comparison with Electron-Beam CT Radiology, May 1, 2007; 243(2): 405 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Michaely, H. Kramer, N. Oesingmann, K.-P. Lodemann, M. F. Reiser, and S. O. Schoenberg Semiquantitative Assessment of First-Pass Renal Perfusion at 1.5 T: Comparison of 2D Saturation Recovery Sequences With and Without Parallel Imaging Am. J. Roentgenol., April 1, 2007; 188(4): 919 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Daghini, L. Juillard, J. A. Haas, J. D. Krier, J. C. Romero, and L. O. Lerman Comparison of Mathematic Models for Assessment of Glomerular Filtration Rate with Electron-Beam CT in Pigs Radiology, February 1, 2007; 242(2): 417 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Chade, J. D. Krier, S. C. Textor, A. Lerman, and L. O. Lerman Endothelin-A Receptor Blockade Improves Renal Microvascular Architecture and Function in Experimental Hypercholesterolemia J. Am. Soc. Nephrol., December 1, 2006; 17(12): 3394 - 3403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Chade, X. Zhu, O. P. Mushin, C. Napoli, A. Lerman, and L. O. Lerman Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia FASEB J, August 1, 2006; 20(10): 1706 - 1708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Daghini, A. R. Chade, J. D. Krier, D. Versari, A. Lerman, and L. O. Lerman Acute inhibition of the endogenous xanthine oxidase improves renal hemodynamics in hypercholesterolemic pigs Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R609 - R615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Michaely, S. O. Schoenberg, N. Oesingmann, C. Ittrich, C. Buhlig, D. Friedrich, A. Struwe, J. Rieger, C. Reininger, W. Samtleben, et al. Renal Artery Stenosis: Functional Assessment with Dynamic MR Perfusion Measurements--Feasibility Study Radiology, February 1, 2006; 238(2): 586 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Jones, K. Easley, S. B. Little, H. Scherz, A. J. Kirsch, and J. D. Grattan-Smith Dynamic Contrast-Enhanced MR Urography in the Evaluation of Pediatric Hydronephrosis: Part 1, Functional Assessment Am. J. Roentgenol., December 1, 2005; 185(6): 1598 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. McDaniel, R. A. Jones, H. Scherz, A. J. Kirsch, S. B. Little, and J. D. Grattan-Smith Dynamic Contrast-Enhanced MR Urography in the Evaluation of Pediatric Hydronephrosis: Part 2, Anatomic and Functional Assessment of Uteropelvic Junction Obstruction Am. J. Roentgenol., December 1, 2005; 185(6): 1608 - 1614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Chade, O. P. Mushin, X. Zhu, M. Rodriguez-Porcel, J. P. Grande, S. C. Textor, A. Lerman, and L. O. Lerman Pathways of Renal Fibrosis and Modulation of Matrix Turnover in Experimental Hypercholesterolemia Hypertension, October 1, 2005; 46(4): 772 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Chade, J. Herrmann, X. Zhu, J. D. Krier, A. Lerman, and L. O. Lerman Effects of Proteasome Inhibition on the Kidney in Experimental Hypercholesterolemia J. Am. Soc. Nephrol., April 1, 2005; 16(4): 1005 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-Y. Zhu, A. R. Chade, M. Rodriguez-Porcel, M. D. Bentley, E. L. Ritman, A. Lerman, and L. O. Lerman Cortical Microvascular Remodeling in the Stenotic Kidney: Role of Increased Oxidative Stress Arterioscler. Thromb. Vasc. Biol., October 1, 2004; 24(10): 1854 - 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Chade, J. D. Krier, M. Rodriguez-Porcel, J. F. Breen, M. A. McKusick, A. Lerman, and L. O. Lerman Comparison of acute and chronic antioxidant interventions in experimental renovascular disease Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1079 - F1086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Chade, M. Rodriguez-Porcel, J. Herrmann, X. Zhu, J. P. Grande, C. Napoli, A. Lerman, and L. O. Lerman Antioxidant Intervention Blunts Renal Injury in Experimental Renovascular Disease J. Am. Soc. Nephrol., April 1, 2004; 15(4): 958 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Chade, M. Rodriguez-Porcel, J. Herrmann, J. D. Krier, X. Zhu, A. Lerman, and L. O. Lerman Beneficial Effects of Antioxidant Vitamins on the Stenotic Kidney Hypertension, October 1, 2003; 42(4): 605 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Chade, M. Rodriguez-Porcel, J. P. Grande, X. Zhu, V. Sica, C. Napoli, T. Sawamura, S. C. Textor, A. Lerman, and L. O. Lerman Mechanisms of Renal Structural Alterations in Combined Hypercholesterolemia and Renal Artery Stenosis Arterioscler. Thromb. Vasc. Biol., July 1, 2003; 23(7): 1295 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Wilson, A. R. Chade, A. Feldstein, T. Sawamura, C. Napoli, A. Lerman, and L. O. Lerman Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia Nephrol. Dial. Transplant., April 1, 2003; 18(4): 703 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rodriguez-Porcel, A. Lerman, J. Herrmann, R. S. Schwartz, T. Sawamura, M. Condorelli, C. Napoli, and L. O. Lerman Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature Cardiovasc Res, April 1, 2003; 58(1): 213 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.A. Calabresi, H. Austin, M.K. Racke, A. Goodman, P. Choyke, H. Maloni, and H.F. McFarland Impaired renal function in progressive multiple sclerosis Neurology, December 10, 2002; 59(11): 1799 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Krier, M. Rodriguez-Porcel, P. J. M. Best, J. C. Romero, A. Lerman, and L. O. Lerman Vascular responses in vivo to 8-epi PGF2alpha in normal and hypercholesterolemic pigs Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R303 - R308. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
