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1 Department of Cellular and Molecular Physiology; 2 Aventis Pharma Deutschland, Frankfurt am Main 65926, Germany; and 3 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8026
This study assessed the functional role of
Na+/H+ exchanger (NHE) isoforms NHE3 and NHE2
in the proximal tubule, loop of Henle, and distal convoluted tubule of
the rat kidney by comparing sensitivity of transport to inhibition by
Hoe-694 (an agent known to inhibit NHE2 but not NHE3) and S-3226 (an
agent with much higher affinity for NHE3 than NHE2). Rates of transport
of fluid (Jv) and HCO
sodium/hydrogen exchange; acidification; proximal; loop of Henle; distal convoluted tubule; sodium/hydrogen exchanger
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