| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Service de Physiologie et Pharmacologie, Faculté de Médecine et de Pharmacie, Université de Mons-Hainaut, 7000 Mons, Belgium
First published August 15, 2001; 10.1152/ajprenal.00078.2001.
Renal blood flow (RBF)
autoregulatory efficiency may be enhanced during NO inhibition in the
rat, as recently reported. Under these conditions, endothelin (ET)
synthesis and release may be increased. Our purpose was therefore to
determine the role of ET in RBF autoregulatory changes induced by NO
inhibition. To address this point, ETA/B receptors were
blocked in anesthetized rats with bosentan, or selectively with BQ-610
or BQ-788. NO synthesis was inhibited with
NG-nitro-L-arginine methyl ester
(L-NAME). Mean arterial pressure (MAP) was
decreased after bosentan (
10 mmHg; P < 0.01) or
increased after L-NAME (25 mmHg; P < 0.001). RBF measured with an electromagnetic flow probe was reduced by
L-NAME (50%) and by BQ-788 (24%). The pressure limits
of the autoregulatory plateau (PA ~100 mmHg) and of no
RBF autoregulation (Po ~80 mmHg) were significantly lowered by 15 mmHg after L-NAME but were unchanged after
bosentan, BQ-610, or BQ-788. During NO inhibition, autoregulatory
resetting was completely hindered by bosentan (PA ~100
mmHg) and by ETB receptor blockade with BQ-788
(PA ~106 mmHg), but not by ETA receptor blockade with BQ-610 (PA ~85 mmHg). These results suggest
that the involvement of ET in the RBF autoregulatory resetting occurs during NO inhibition, possibly by preferential activation of the ETB receptor. However, the relative contribution of ET
receptor subtypes remains to be further specified.
renal vascular resistance; renal hemodynamics; autoregulation; angiotensin; nitric oxide
This article has been cited by other articles:
|
|
 |
|
  Z. Miloradovic, M. Jerkic, D. Jovovic, N. Mihailovic-Stanojevic, J. G. Milanovic, G. Stosic, and J. Markovic-Lipkovski Bosentan and losartan ameliorate acute renal failure associated with mild but not strong NO blockade Nephrol. Dial. Transplant., September 1, 2007; 22(9): 2476 - 2484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Cupples and B. Braam Assessment of renal autoregulation Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1105 - F1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shi, C. Lau, and W. A. Cupples Interactive modulation of renal myogenic autoregulation by nitric oxide and endothelin acting through ET-B receptors Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R354 - R361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shi, X. Wang, K. H. Chon, and W. A. Cupples Tubuloglomerular feedback-dependent modulation of renal myogenic autoregulation by nitric oxide Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R982 - R991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Just and W. J. Arendshorst Nitric oxide blunts myogenic autoregulation in rat renal but not skeletal muscle circulation via tubuloglomerular feedback J. Physiol., December 15, 2005; 569(3): 959 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. A. Majid, A. Nishiyama, K. E. Jackson, and A. Castillo Superoxide scavenging attenuates renal responses to ANG II during nitric oxide synthase inhibition in anesthetized dogs Am J Physiol Renal Physiol, February 1, 2005; 288(2): F412 - F419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Racasan, J. A. Joles, P. Boer, H. A. Koomans, and B. Braam NO dependency of RBF and autoregulation in the spontaneously hypertensive rat Am J Physiol Renal Physiol, July 1, 2003; 285(1): F105 - F112. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
