AJP - Renal Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 282: F179-F190, 2002;
0363-6127/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (49)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Apodaca, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Apodaca, G.
Vol. 282, Issue 2, F179-F190, February 2002

INVITED REVIEW
Modulation of membrane traffic by mechanical stimuli

Gerard Apodaca

Laboratory of Epithelial Cell Biology, Renal-Electrolyte Division, Department of Medicine, and Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

All cells experience and respond to mechanical stimuli, such as changes in plasma membrane tension, shear stress, hydrostatic pressure, and compression. This review is an examination of the changes in membrane traffic that occur in response to mechanical forces. The plasma membrane has an associated tension that modulates both exocytosis and endocytosis. As membrane tension increases, exocytosis is stimulated, which acts to decrease membrane tension. In contrast, increased membrane tension slows endocytosis, whereas decreased tension stimulates internalization. In most cases, secretion is stimulated by external mechanical stimuli. However, in some cells mechanical forces block secretion. External stimuli also enhance membrane and fluid endocytosis in several cell types. Transduction of mechanical stimuli into changes in exocytosis/endocytosis may involve the cytoskeleton, stretch-activated channels, integrins, phospholipases, tyrosine kinases, and cAMP.

membrane tension; stretch; mechanical forces; exocytosis; endocytosis; secretion; cytoskeleton; mechanosensors; signal transduction


This article has been cited by other articles:


Home page
 Circ. Res.Home page
B. D.M. Meijering, L. J.M. Juffermans, A. van Wamel, R. H. Henning, I. S. Zuhorn, M. Emmer, A. M.G. Versteilen, W. J. Paulus, W. H. van Gilst, K. Kooiman, et al.
Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation
Circ. Res., March 13, 2009; 104(5): 679 - 687.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. C. Geiger, C. D. Kaufman, A. P. Lam, G. R. S. Budinger, and D. A. Dean
Tubulin Acetylation and Histone Deacetylase 6 Activity in the Lung under Cyclic Load
Am. J. Respir. Cell Mol. Biol., January 1, 2009; 40(1): 76 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
W. Yu, P. Khandelwal, and G. Apodaca
Distinct Apical and Basolateral Membrane Requirements for Stretch-induced Membrane Traffic at the Apical Surface of Bladder Umbrella Cells
Mol. Biol. Cell, January 1, 2009; 20(1): 282 - 295.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. Woo, A. K. Dutta, V. Patel, C. Kresge, and A. P. Feranchak
Fluid flow induces mechanosensitive ATP release, calcium signalling and Cl- transport in biliary epithelial cells through a PKC{zeta}-dependent pathway
J. Physiol., June 1, 2008; 586(11): 2779 - 2798.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
L. Zonia and T. Munnik
Vesicle trafficking dynamics and visualization of zones of exocytosis and endocytosis in tobacco pollen tubes
J. Exp. Bot., March 1, 2008; 59(4): 861 - 873.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. W. Wong, S. J. Scales, and D. E. Reilly
DNA Internalized via Caveolae Requires Microtubule-dependent, Rab7-independent Transport to the Late Endocytic Pathway for Delivery to the Nucleus
J. Biol. Chem., August 3, 2007; 282(31): 22953 - 22963.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Elad, S. Naftali, M. Rosenfeld, and M. Wolf
Physical stresses at the air-wall interface of the human nasal cavity during breathing
J Appl Physiol, March 1, 2006; 100(3): 1003 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
J C H Tan, F B Kalapesi, and M T Coroneo
Mechanosensitivity and the eye: cells coping with the pressure.
Br. J. Ophthalmol., March 1, 2006; 90(3): 383 - 388.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Pan, I. Copland, M. Post, H. Yeger, and E. Cutz
Mechanical stretch-induced serotonin release from pulmonary neuroendocrine cells: implications for lung development
Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L185 - L193.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. C. Wagner, B. L. Blazer-Yost, J. Boyd-White, A. Srirangam, J. Pennington, and S. Bennett
Expression of the unconventional myosin Myo1c alters sodium transport in M1 collecting duct cells
Am J Physiol Cell Physiol, July 1, 2005; 289(1): C120 - C129.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
P. Yang, O. Agapova, A. Parker, W. Shannon, P. Pecen, J. Duncan, M. Salvador-Silva, and M. R. Hernandez
DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure
Physiol Genomics, April 13, 2004; 17(2): 157 - 169.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. C. Y. Wang, J.-M. Lee, J. P. Johnson, T. R. Kleyman, R. Bridges, and G. Apodaca
Hydrostatic pressure-regulated ion transport in bladder uroepithelium
Am J Physiol Renal Physiol, October 1, 2003; 285(4): F651 - F663.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Yamamoto, T. Sokabe, N. Ohura, H. Nakatsuka, A. Kamiya, and J. Ando
Endogenously released ATP mediates shear stress-induced Ca2+ influx into pulmonary artery endothelial cells
Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H793 - H803.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Ou, P. Strege, S. M. Miller, J. Makielski, M. Ackerman, S. J. Gibbons, and G. Farrugia
Syntrophin gamma 2 Regulates SCN5A Gating by a PDZ Domain-mediated Interaction
J. Biol. Chem., January 10, 2003; 278(3): 1915 - 1923.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
K. J. Cavanaugh Jr. and S. S. Margulies
Measurement of stretch-induced loss of alveolar epithelial barrier integrity with a novel in vitro method
Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1801 - C1808.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Heidelberger, Z.-Y. Zhou, and G. Matthews
Multiple Components of Membrane Retrieval in Synaptic Terminals Revealed by Changes in Hydrostatic Pressure
J Neurophysiol, November 1, 2002; 88(5): 2509 - 2517.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Herzog, H. Sager, E. Khmelevski, A. Deylig, and W. D. Ito
Collateral arteries grow from preexisting anastomoses in the rat hindlimb
Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H2012 - H2020.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. T. Truschel, E. Wang, W. G. Ruiz, S.-M. Leung, R. Rojas, J. Lavelle, M. Zeidel, D. Stoffer, and G. Apodaca
Stretch-regulated Exocytosis/Endocytosis in Bladder Umbrella Cells
Mol. Biol. Cell, March 1, 2002; 13(3): 830 - 846.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online