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Am J Physiol Renal Physiol 282: F256-F264, 2002; doi:10.1152/ajprenal.00056.2001
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Vol. 282, Issue 2, F256-F264, February 2002

Peritubular AVP regulates bicarbonate reabsorption in cortical distal tubule via V1 and V2 receptors

Raif Musa-Aziz1, Maria Luisa Morais Barreto-Chaves2, and Margarida De Mello-Aires1

Departments of 1 Physiology and Biophysics and 2 Anatomy, Instituto de Ciências Biomédicas, University of São Paulo, São Paulo 05508-900, Brazil

10.1152/ajprenal.00056.2001. Peritubular arginine vasopressin (AVP) regulates bicarbonate reabsorption in the cortical distal tubule via V1 and V2 receptors. The dose-dependent effects of peritubular AVP on net bicarbonate reabsorption (JHCO<UP><SUB>3</SUB><SUP>−</SUP></UP>) were evaluated by stationary microperfusion of in vivo early (ED; distal convoluted tubule) and late distal (LD; connecting tubule and initial collecting duct) segments of rat kidney, using double-barreled H+-sensitive, ion-exchange resin/reference (1 M KCl) microelectrodes. AVP (10-11 M) perfused into peritubular capillaries increased JHCO<UP><SUB>3</SUB><SUP>−</SUP></UP>, compared with basal levels during intact capillary perfusion with blood, in ED and LD segments. AVP (10-9 M) also increased JHCO<UP><SUB>3</SUB><SUP>−</SUP></UP> in both segments, but the effect of AVP (10-11 M) was significantly higher. A specificV1-receptor antagonist alone or with AVP (10-11 or 10-9 M) reduced JHCO<UP><SUB>3</SUB><SUP>−</SUP></UP> below basal levels. A specific V2-receptor antagonist alone or plus AVP (10-11 M) did not affect JHCO<UP><SUB>3</SUB><SUP>−</SUP></UP> but increased AVP (10-9 M)-mediated stimulation. 8-Bromoadenosine 3',5'-cyclic monophosphate alone reduced JHCO<UP><SUB>3</SUB><SUP>−</SUP></UP> below basal levels and also reduced AVP (10-11 M)-mediated stimulation. (Deamino-Cys1, D-Arg8) vasopressin (a V2-selective agonist) also reduced JHCO<UP><SUB>3</SUB><SUP>−</SUP></UP> below basal levels. These results show that peritubular AVP stimulates JHCO<UP><SUB>3</SUB><SUP>−</SUP></UP> in ED and LD segments via basolateral V1 receptors and that basolateral V2 receptors have a dose-dependent inhibitory effect mediated by cAMP. The data also indicate that endogenous AVP stimulates distal JHCO<UP><SUB>3</SUB><SUP>−</SUP></UP> via basolateral V1 receptors.

arginine vasorpressin; distal bicarbonate reabsorption


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