| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois 60637; and 2 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Ischemia-reperfusion injury
(IRI) is a complex and incompletely understood process involving a
cascade of events that culminates in apoptotic and/or necrotic cell
death. Natural IgM antibodies and complement have been implicated
in the pathogenesis of IRI in a variety of organ systems as have T
lymphocytes in renal IRI. To investigate the role of Ig and T
lymphocytes in renal IRI, recombination-activating gene
(RAG)-1-deficient mice were studied. RAG-1(
/) mice were not
protected from acute renal failure induced by 27.5 min of bilateral
renal ischemia and subsequent reperfusion [serum urea nitrogen
levels 30 h after reperfusion, 155.2 ± 5.6 and 152.8 ± 11.4 mg/dl in RAG-1(/) and wild-type mice, respectively; n = 13 each]. Histological examination showed acute
tubular necrosis and neutrophilic infiltration with no significant
differences between groups. In contrast with other organ systems, Igs
were not found in kidneys at time points ranging from 1 min to 30 h after ischemia. Thus Igs and mature T lymphocytes do not
appear to play a significant role in the pathogenesis of IRI in the kidney.
acute renal failure; neutrophils; complement; recombination activating gene
This article has been cited by other articles:
|
|
 |
|
  T. Moses, L. Wagner, and S. D. Fleming TLR4-mediated Cox-2 expression increases intestinal ischemia/reperfusion-induced damage J. Leukoc. Biol., October 1, 2009; 86(4): 971 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Khan, D. Susa, J. W. van den Berg, M. Huisman, M. H. Ameling, S. van den Engel, H. P. Roest, J. N. M. IJzermans, W. A. Dik, R. Benner, et al. Amelioration of renal ischaemia-reperfusion injury by synthetic oligopeptides related to human chorionic gonadotropin Nephrol. Dial. Transplant., September 1, 2009; 24(9): 2701 - 2708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Furuichi, J.-L. Gao, R. Horuk, T. Wada, S. Kaneko, and P. M. Murphy Chemokine Receptor CCR1 Regulates Inflammatory Cell Infiltration after Renal Ischemia-Reperfusion Injury J. Immunol., December 15, 2008; 181(12): 8670 - 8676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Alexander, Y. Wang, A. Chang, A. Jacob, A. W.M. Minto, M. Karmegam, M. Haas, and R. J. Quigg Mouse Podocyte Complement Factor H: The Functional Analog to Human Complement Receptor 1 J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1157 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Devarajan Update on Mechanisms of Ischemic Acute Kidney Injury J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1503 - 1520. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fagoonee, J. Gburek, E. Hirsch, S. Marro, S. K. Moestrup, J. M. Laurberg, E. I. Christensen, L. Silengo, F. Altruda, and E. Tolosano Plasma Protein Haptoglobin Modulates Renal Iron Loading Am. J. Pathol., April 1, 2005; 166(4): 973 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kishino, K. Yukawa, K. Hoshino, A. Kimura, N. Shirasawa, H. Otani, T. Tanaka, K. Owada-Makabe, Y. Tsubota, M. Maeda, et al. Deletion of the Kinase Domain in Death-Associated Protein Kinase Attenuates Tubular Cell Apoptosis in Renal Ischemia-Reperfusion Injury J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1826 - 1834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Togel, J. Isaac, and C. Westenfelder Hematopoietic Stem Cell Mobilization-Associated Granulocytosis Severely Worsens Acute Renal Failure J. Am. Soc. Nephrol., May 1, 2004; 15(5): 1261 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Quigg Complement and the Kidney J. Immunol., October 1, 2003; 171(7): 3319 - 3324. [Full Text] [PDF]
|
|
|
|
|
|
J. V. Bonventre and J. M. Weinberg Recent Advances in the Pathophysiology of Ischemic Acute Renal Failure J. Am. Soc. Nephrol., August 1, 2003; 14(8): 2199 - 2210. [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Padanilam Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis Am J Physiol Renal Physiol, April 1, 2003; 284(4): F608 - F627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Inal, M. Pascual, P. Lesavre, and J.-A. Schifferli Complement inhibition in renal diseases Nephrol. Dial. Transplant., February 1, 2003; 18(2): 237 - 240. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Thurman, D. Ljubanovic, C. L. Edelstein, G. S. Gilkeson, and V. M. Holers Lack of a Functional Alternative Complement Pathway Ameliorates Ischemic Acute Renal Failure in Mice J. Immunol., February 1, 2003; 170(3): 1517 - 1523. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
