| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202
Nitric oxide (NO) plays an important role in various physiological processes in the kidney. In vivo experiments first suggested that the natriuretic and diuretic effects caused by NO may be due to decreased NaCl and fluid absorption by the nephron. In the last 10 years, several reports have directly demonstrated a role for NO in modulating transport in different tubule segments. The effects of NO on proximal tubule transport are still controversial. Both stimulation and inhibition of net fluid and bicarbonate have been reported in this segment, whereas only inhibitory effects of NO have been found in Na/H exchanger and Na/K-ATPase activity. The effects of NO in the thick ascending limb are more homogeneous than in the proximal tubule. In this segment, NO decreases net Cl and bicarbonate absorption. A direct inhibitory effect of NO on the Na-K-2Cl cotransporter and the Na/H exchanger has been reported, while NO was found to stimulate apical K channels in this segment. In the collecting duct, NO inhibits Na absorption and vasopressin-stimulated osmotic water permeability. An inhibitory effect of NO on H-ATPase has also been reported in intercalated cells of the collecting duct. Overall, the reported effects of NO in the different nephron segments mostly agree with the natriuretic and diuretic effects observed in vivo. However, the net effect of NO on transport is still controversial in some segments, and in cases like the distal tubule, it has not been studied.
sodium/hydrogen exchange; sodium-potassium-2 chloride costransport; epithelial sodium channel; sodium/potassium-adenosine triphosphatase; proximal tubule; thick ascending limb; collecting duct
This article has been cited by other articles:
|
|
 |
|
  A. A. Banday and M. F. Lokhandwala Inhibition of natriuretic factors increases blood pressure in rats Am J Physiol Renal Physiol, August 1, 2009; 297(2): F397 - F402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Xia, L. Chen, R. W. Muh, P.-L. Li, and N. Li Production and Actions of Hydrogen Sulfide, a Novel Gaseous Bioactive Substance, in the Kidneys J. Pharmacol. Exp. Ther., June 1, 2009; 329(3): 1056 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Riazi, S. Tiwari, N. Sharma, A. Rash, and C. M. Ecelbarger Abundance of the Na-K-2Cl cotransporter NKCC2 is increased by high-fat feeding in Fischer 344 X Brown Norway (F1) rats Am J Physiol Renal Physiol, April 1, 2009; 296(4): F762 - F770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Evans, B. S. Gardiner, D. W. Smith, and P. M. O'Connor Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1259 - F1270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. I. Abdullah, P. L. Pedraza, J. C. McGiff, and N. R. Ferreri CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism Am J Physiol Renal Physiol, February 1, 2008; 294(2): F345 - F354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Onozato, A. Tojo, J. Leiper, T. Fujita, F. Palm, and C. S. Wilcox Expression of NG,NG-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney: Effects of Angiotensin II Receptor Blockers Diabetes, January 1, 2008; 57(1): 172 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Soodvilai, Z. Jia, and T. Yang Hydrogen peroxide stimulates chloride secretion in primary inner medullary collecting duct cells via mPGES-1-derived PGE2 Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1571 - F1576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ahmed, B. A. Kemp, N. L. Howell, H. M. Siragy, and R. M. Carey Extracellular Renal Guanosine Cyclic 3'5'-Monophosphate Modulates Nitric Oxide and Pressure-Induced Natriuresis Hypertension, November 1, 2007; 50(5): 958 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Tripatara, N. S.A. Patel, A. Webb, K. Rathod, F. M.J. Lecomte, E. Mazzon, S. Cuzzocrea, M. M. Yaqoob, A. Ahluwalia, and C. Thiemermann Nitrite-Derived Nitric Oxide Protects the Rat Kidney against Ischemia/Reperfusion Injury In Vivo: Role for Xanthine Oxidoreductase J. Am. Soc. Nephrol., February 1, 2007; 18(2): 570 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ge, A. Bagnall, P. K. Stricklett, K. Strait, D. J. Webb, Y. Kotelevtsev, and D. E. Kohan Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1274 - F1280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsuruoka, S. Watanabe, J. M. Purkerson, A. Fujimura, and G. J. Schwartz Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis Am J Physiol Renal Physiol, October 1, 2006; 291(4): F866 - F873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Herrera, N. J. Hong, and J. L. Garvin Aquaporin-1 Transports NO Across Cell Membranes Hypertension, July 1, 2006; 48(1): 157 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Neuhofer and F.-X. Beck Survival in Hostile Environments: Strategies of Renal Medullary Cells Physiology, June 1, 2006; 21(3): 171 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Herrera, P. A. Ortiz, and J. L. Garvin Regulation of thick ascending limb transport: role of nitric oxide Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1279 - F1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-F. Cheng, M.-Z. Zhang, and R. C. Harris Nitric oxide stimulates cyclooxygenase-2 in cultured cTAL cells through a p38-dependent pathway Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1391 - F1397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Stricklett, A. K. Hughes, and D. E. Kohan Endothelin-1 stimulates NO production and inhibits cAMP accumulation in rat inner medullary collecting duct through independent pathways Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1315 - F1319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Mullins, M. A. Bailey, and J. J. Mullins Hypertension, Kidney, and Transgenics: A Fresh Perspective Physiol Rev, April 1, 2006; 86(2): 709 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Silva, W. H. Beierwaltes, and J. L. Garvin Extracellular ATP Stimulates NO Production in Rat Thick Ascending Limb Hypertension, March 1, 2006; 47(3): 563 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Bagnall, P. C. Dent, A. Walkowska, J. Sadowski, and E. J. Johns Nitric oxide inhibition and the impact on renal nerve-mediated antinatriuresis and antidiuresis in the anaesthetized rat J. Physiol., December 15, 2005; 569(3): 849 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Mount, R. E. Hill, S. A. Fraser, V. Levidiotis, F. Katsis, B. E. Kemp, and D. A. Power Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177 Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1103 - F1115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Wilcox Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension? Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R913 - R935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Helms, L. Yu, B. Malik, D. J. Kleinhenz, C. M. Hart, and D. C. Eaton Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia Am J Physiol Cell Physiol, September 1, 2005; 289(3): C717 - C726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-P. Yip Flash photolysis of caged nitric oxide inhibits proximal tubular fluid reabsorption in free-flow nephron Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R620 - R626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Herrera and J. L. Garvin Recent Advances in the Regulation of Nitric Oxide in the Kidney Hypertension, June 1, 2005; 45(6): 1062 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Pluznick, P. Wei, P. R. Grimm, and S. C. Sansom BK-{beta}1 subunit: immunolocalization in the mammalian connecting tubule and its role in the kaliuretic response to volume expansion Am J Physiol Renal Physiol, April 1, 2005; 288(4): F846 - F854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Wilcox and D. Gutterman Focus on oxidative stress in the cardiovascular and renal systems Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H3 - H6. [Full Text] [PDF]
|
|
|
|
|
|
M. Herrera and J. L. Garvin A high-salt diet stimulates thick ascending limb eNOS expression by raising medullary osmolality and increasing release of endothelin-1 Am J Physiol Renal Physiol, January 1, 2005; 288(1): F58 - F64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Lee, J. M. Sasser, J. L. Hobbs, A. Boriskie, D. M. Pollock, P. K. Carmines, and J. S. Pollock Posttranslational regulation of NO synthase activity in the renal medulla of diabetic rats Am J Physiol Renal Physiol, January 1, 2005; 288(1): F82 - F90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhang, T. Pibulsonggram, and A. Edwards Determinants of basal nitric oxide concentration in the renal medullary microcirculation Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1189 - F1203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang and T. L. Pallone Response of descending vasa recta to luminal pressure Am J Physiol Renal Physiol, September 1, 2004; 287(3): F535 - F542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Ortiz, N. J. Hong, and J. L. Garvin Luminal flow induces eNOS activation and translocation in the rat thick ascending limb Am J Physiol Renal Physiol, August 1, 2004; 287(2): F274 - F280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Ortiz, N. J. Hong, and J. L. Garvin Luminal flow induces eNOS activation and translocation in the rat thick ascending limb. II. Role of PI3-kinase and Hsp90 Am J Physiol Renal Physiol, August 1, 2004; 287(2): F281 - F288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Evans, R. E. Rose, J. M. Roeser, and J. D. Stidham NaCl transport across the opercular epithelium of Fundulus heteroclitus is inhibited by an endothelin to NO, superoxide, and prostanoid signaling axis Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R560 - R568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zimpelmann, N. Li, and K. D. Burns Nitric oxide inhibits superoxide-stimulated urea permeability in the rat inner medullary collecting duct Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1160 - F1167. [Abstract] [Full Text]
|
|
|
|
|
|
P. A. Ortiz, N. J. Hong, D. Wang, and J. L. Garvin Gene Transfer of eNOS to the Thick Ascending Limb of eNOS-KO Mice Restores the Effects of L-Arginine on NaCl Absorption Hypertension, October 1, 2003; 42(4): 674 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C Hercule, M.-H. Wang, and A. O Oyekan Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat J. Physiol., September 15, 2003; 551(3): 971 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Cowley Jr., T. Mori, D. Mattson, and A.-P. Zou Role of renal NO production in the regulation of medullary blood flow Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1355 - R1369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Tipsmark and S. S. Madsen Regulation of Na+/K+-ATPase activity by nitric oxide in the kidney and gill of the brown trout (Salmo trutta) J. Exp. Biol., May 1, 2003; 206(9): 1503 - 1510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Ortiz and J. L. Garvin Cardiovascular and renal control in NOS-deficient mouse models Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R628 - R638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ortiz, B. A. Stoos, N. J. Hong, D. M. Boesch, C. F. Plato, and J. L. Garvin High-Salt Diet Increases Sensitivity to NO and eNOS Expression But Not NO Production in THALs Hypertension, March 1, 2003; 41(3): 682 - 687. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
