| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Medicine, 2 Physiology, and Biophysics and 3 Program in Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794-8152
Caveolae, flask-shaped invaginations of the plasma membrane occupying up to 30% of cell surface in capillaries, represent a predominant location of endothelial nitric oxide synthase (eNOS) in endothelial cells. The caveolar coat protein caveolin forms high-molecular-weight, Triton-insoluble complexes through oligomerization mediated by interactions between NH2-terminal residues 61-101. eNOS is targeted to caveolae by cotranslational N-myristoylation and posttranslational palmitoylation. Caveolin-1 coimmunoprecipitates with eNOS; interaction with eNOS occurs via the caveolin-1 scaffolding domain and appears to result in the inhibition of NOS activity. The inhibitory conformation of eNOS is reversed by the addition of excess Ca2+/calmodulin and by Akt-induced phosphorylation of eNOS. Here, we shall dissect the system using the classic paradigm of a reflex loop: 1) the action of afferent elements, such as fluid shear stress and its putative caveolar sensor, on caveolae; 2) the ways in which afferent signals may affect the central element, the activation of the eNOS-nitric oxide system; and 3) several resultant well-established and novel physiologically important effector mechanisms, i.e., vasorelaxation, angiogenesis, membrane fluidity, endothelial permeability, deterrance of inflammatory cells, and prevention of platelet aggregation.
endothelial nitric oxide synthase
This article has been cited by other articles:
|
|
 |
|
  L. Shu, J. L. Park, J. Byun, S. Pennathur, J. Kollmeyer, and J. A. Shayman Decreased Nitric Oxide Bioavailability in a Mouse Model of Fabry Disease J. Am. Soc. Nephrol., September 1, 2009; 20(9): 1975 - 1985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Rho, S. M. Dong, S. Kang, S.-S. Seo, C. W. Yoo, D. O. Lee, J. S. Woo, and S.-Y. Park Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesis Carcinogenesis, November 1, 2008; 29(11): 2106 - 2111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Averna, R. Stifanese, R. De Tullio, M. Passalacqua, F. Salamino, S. Pontremoli, and E. Melloni Functional Role of HSP90 Complexes with Endothelial Nitric-oxide Synthase (eNOS) and Calpain on Nitric Oxide Generation in Endothelial Cells J. Biol. Chem., October 24, 2008; 283(43): 29069 - 29076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bertuglia Intermittent hypoxia modulates nitric oxide-dependent vasodilation and capillary perfusion during ischemia-reperfusion-induced damage Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1914 - H1922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Elsasser, T. J. Caperna, C-J. Li, S. Kahl, and J. L. Sartin Critical control points in the impact of the proinflammatory immune response on growth and metabolism J Anim Sci, April 1, 2008; 86(14_suppl): E105 - E125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Genis, P. Gonzalo, A. S. Tutor, B. G. Galvez, A. Martinez-Ruiz, C. Zaragoza, S. Lamas, K. Tryggvason, S. S. Apte, and A. G. Arroyo Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells Blood, October 15, 2007; 110(8): 2916 - 2923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Lin, J. Yu, T. Murata, and W. C. Sessa Caveolin-1-Deficient Mice Have Increased Tumor Microvascular Permeability, Angiogenesis, and Growth Cancer Res., March 15, 2007; 67(6): 2849 - 2856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Komers, W. E. Schutzer, J. F. Reed, J. N. Lindsley, T. T. Oyama, D. C. Buck, S. L. Mader, and S. Anderson Altered Endothelial Nitric Oxide Synthase Targeting and Conformation and Caveolin-1 Expression in the Diabetic Kidney Diabetes, June 1, 2006; 55(6): 1651 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Zhang, E. G. Teggatz, A. Y. Zhang, M. J. Koeberl, F. Yi, L. Chen, and P.-L. Li Cyclic ADP ribose-mediated Ca2+ signaling in mediating endothelial nitric oxide production in bovine coronary arteries Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1172 - H1181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Louden, D. Brott, A. Katein, T. Kelly, S. Gould, H. Jones, G. Betton, J.-P. Valetin, and R. J. Richardson Biomarkers and Mechanisms of Drug-Induced Vascular Injury in Non-Rodents Toxicol Pathol, January 1, 2006; 34(1): 19 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kondrikov, H.-R. Han, E. R. Block, and Y. Su Growth and density-dependent regulation of NO synthase by the actin cytoskeleton in pulmonary artery endothelial cells Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L41 - L50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Noble, J. Zhang, and S. Wray Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approach J. Physiol., January 1, 2006; 570(1): 29 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Zhang, F. Yi, G. Zhang, E. Gulbins, and P.-L. Li Lipid Raft Clustering and Redox Signaling Platform Formation in Coronary Arterial Endothelial Cells Hypertension, January 1, 2006; 47(1): 74 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Predescu, S. Predescu, J. Shimizu, K. Miyawaki-Shimizu, and A. B. Malik Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity Am J Physiol Lung Cell Mol Physiol, September 1, 2005; 289(3): L371 - L381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Glass, T. M. Pocock, F. E. Curry, and D. O. Bates Cytosolic Ca2+ concentration and rate of increase of the cytosolic Ca2+ concentration in the regulation of vascular permeability in Rana in vivo J. Physiol., May 1, 2005; 564(3): 817 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Zhang and T. L. Pallone Response of descending vasa recta to luminal pressure Am J Physiol Renal Physiol, September 1, 2004; 287(3): F535 - F542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, K. Rhinehart, W. Kwon, E. Weinman, and T. L. Pallone ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H773 - H781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. V. Smirnova, T. Sawamura, and M. S. Goligorsky Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in endothelial cells by nitric oxide deficiency Am J Physiol Renal Physiol, July 1, 2004; 287(1): F25 - F32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Barbuti, B. Gravante, M. Riolfo, R. Milanesi, B. Terragni, and D. DiFrancesco Localization of Pacemaker Channels in Lipid Rafts Regulates Channel Kinetics Circ. Res., May 28, 2004; 94(10): 1325 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Vallejo and C. D. Hardin Metabolic organization in vascular smooth muscle: distribution and localization of caveolin-1 and phosphofructokinase Am J Physiol Cell Physiol, January 1, 2004; 286(1): C43 - C54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Bivalacqua, M. F. Usta, H. C. Champion, P. J. Kadowitz, and W. J. G. Hellstrom Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease J Androl, November 1, 2003; 24(6_suppl): S17 - S37. [Full Text] [PDF]
|
|
|
|
|
|
B. C. Kone, T. Kuncewicz, W. Zhang, and Z.-Y. Yu Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide Am J Physiol Renal Physiol, August 1, 2003; 285(2): F178 - F190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Pallone, Z. Zhang, and K. Rhinehart Physiology of the renal medullary microcirculation Am J Physiol Renal Physiol, February 1, 2003; 284(2): F253 - F266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Cohen, D. S. Park, S. E. Woodman, T. M. Williams, M. Chandra, J. Shirani, A. Pereira de Souza, R. N. Kitsis, R. G. Russell, L. M. Weiss, et al. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts Am J Physiol Cell Physiol, February 1, 2003; 284(2): C457 - C474. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
