| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Nephrology, Friedrich-Alexander-University Erlangen-Nürnberg, D-91054 Erlangen; 2 Department of Chemistry and Physics, Federal Center for Meat Research, D-95326 Kulmbach; and Departments of 3 Biochemistry and 4 Physiology, Free University of Berlin, D-14195 Berlin, Germany
Recent evidence suggested that Na can be stored in an osmotically inactive form. We investigated whether osmotically inactive Na storage is reduced in a rat model of salt-sensitive (SS) hypertension. SS and salt-resistant (SR) Dahl-Rapp rats as well as Sprague-Dawley (SD) rats were fed a high (8%)- or low (0.1%)-NaCl diet for 4 wk (n = 10/group). Mean arterial pressure (MAP) was measured at the end of the experiment. Wet and dry weights, water content, total body Na (TBS), and bone Na content were measured by dessication and dry ashing. MAP was higher in both Dahl strains than in SD rats. In SS rats, 8% NaCl led to Na accumulation, water retention, and hypertension due to impaired renal Na excretion. There was no dietary-induced Na retention in SR and SD rats. TBS was variable; nevertheless, TBS was significantly correlated with body water and MAP in all strains. However, the extent of Na-associated volume and MAP increases was strain specific. Osmotically inactive Na in SD rats was threefold higher than in SS and SR rats. Both SS and SR Dahl rat strains displayed reduced osmotically inactive Na storage capacity compared with SD controls. A predisposition to fluid accumulation and high blood pressure results from this alteration. Additional factors, including impaired renal Na excretion, probably contribute to hypertension in SS rats. Our results draw attention to the role of osmotically inactive Na storage.
salt sensitive; bone sodium; Dahl rats
This article has been cited by other articles:
|
|
 |
|
  F. J. Haddy, T. A. Kotchen, G. Handelman, P. Kotanko, N. W. Levin, F. H. Epstein, H. J. Adrogue, and N. E. Madias Mechanisms of Hypertension N. Engl. J. Med., August 23, 2007; 357(8): 827 - 829. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schafflhuber, N. Volpi, A. Dahlmann, K. F. Hilgers, F. Maccari, P. Dietsch, H. Wagner, F. C. Luft, K.-U. Eckardt, and J. Titze Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1490 - F1500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Rosner and J. Kirven Exercise-Associated Hyponatremia Clin. J. Am. Soc. Nephrol., January 1, 2007; 2(1): 151 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Seeliger, M. Ladwig, and H. W. Reinhardt Are large amounts of sodium stored in an osmotically inactive form during sodium retention? Balance studies in freely moving dogs Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1429 - R1435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Nguyen and I. Kurtz Quantitative interrelationship between Gibbs-Donnan equilibrium, osmolality of body fluid compartments, and plasma water sodium concentration J Appl Physiol, April 1, 2006; 100(4): 1293 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T D Hew-Butler, K Sharwood, M Collins, D Speedy, and T Noakes Sodium supplementation is not required to maintain serum sodium concentrations during an Ironman triathlon. Br. J. Sports Med., March 1, 2006; 40(3): 255 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D.C., L. D.F., W. J., H. D., Y. X, T. J., B. K., S. M., D. P., L. R., et al. Accessory Renal Arteries--Mostly, But Not Always, Innocuous: Renin-Dependent Hypertension Caused by Nonfocal Stenotic Aberrant Renal Arteries--Proof of a New Syndrome. Hypertension 46: 380-385, 2005 J. Am. Soc. Nephrol., January 1, 2006; 17(1): 3 - 11. [Full Text] [PDF]
|
|
|
|
|
|
J. Titze, K. Bauer, M. Schafflhuber, P. Dietsch, R. Lang, K. H. Schwind, F. C. Luft, K.-U. Eckardt, and K. F. Hilgers Internal sodium balance in DOCA-salt rats: a body composition study Am J Physiol Renal Physiol, October 1, 2005; 289(4): F793 - F802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Nguyen and I. Kurtz A new formula for predicting alterations in plasma sodium concentration in peritoneal dialysis Am J Physiol Renal Physiol, June 1, 2005; 288(6): F1113 - F1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Nguyen and I. Kurtz New insights into the pathophysiology of the dysnatremias: a quantitative analysis Am J Physiol Renal Physiol, August 1, 2004; 287(2): F172 - F180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Titze, M. Shakibaei, M. Schafflhuber, G. Schulze-Tanzil, M. Porst, K. H. Schwind, P. Dietsch, and K. F. Hilgers Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H203 - H208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Nguyen and I. Kurtz Determinants of plasma water sodium concentration as reflected in the Edelman equation: role of osmotic and Gibbs-Donnan equilibrium Am J Physiol Renal Physiol, May 1, 2004; 286(5): F828 - F837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Titze, R. Lang, C. Ilies, K. H. Schwind, K. A. Kirsch, P. Dietsch, F. C. Luft, and K. F. Hilgers Osmotically inactive skin Na+ storage in rats Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1108 - F1117. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. K. Nguyen and I. Kurtz Are the total exchangeable sodium, total exchangeable potassium and total body water the only determinants of the plasma water sodium concentration? Nephrol. Dial. Transplant., July 1, 2003; 18(7): 1266 - 1271. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
