AJP - Renal Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 283: F86-F92, 2002. First published January 29, 2002; doi:10.1152/ajprenal.00121.2001
0363-6127/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/1/F86    most recent
00121.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Rodijnen, W. F.
Right arrow Articles by ter Wee, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Rodijnen, W. F.
Right arrow Articles by ter Wee, P. M.
Vol. 283, Issue 1, F86-F92, July 2002

Renal microvascular actions of angiotensin II fragments

William F. van Rodijnen1, Ton A. van Lambalgen1, Michiel H. van Wijhe1, Geert-Jan Tangelder1, and Piet M. ter Wee2

1 Laboratory for Physiology and 2 Department of Nephrology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands

In the present study, we investigated renal microvascular responses to ANG-(1-7) and ANG IV. Diameter changes of small interlobular arteries, afferent arterioles, and efferent arterioles were assessed by using isolated perfused hydronephrotic rat kidneys. ANG-(1-7) and ANG IV concentration dependently decreased the diameters of all investigated renal microvessel, however, with a much lower potency than ANG II. The ANG II type 1 receptor blocker irbesartan completely reversed the responses to ANG-(1-7) and ANG IV, whereas the ANG II type 2 receptor blocker PD-123319 had no effect. Both ANG-(1-7) and ANG IV failed to alter renal microvascular constriction induced by ANG II. In addition, subnanomolar concentrations of ANG-(1-7) had no effect on the myogenic-induced tone of interlobular arteries and afferent arterioles. Thus our data indicate that at high concentrations, ANG-(1-7) and ANG IV are able to activate the ANG II type 1 receptor, thereby inducing renal microvascular constriction. The failure of ANG-(1-7) and ANG IV to reduce ANG II- and pressure-induced constrictions suggests that these fragments do not exert a vasodilator and/or ANG II antagonistic action in the kidney.

angiotensin-(1-7); angiotensin IV; renal microvasculature; isolated perfused hydronephrotic rat kidney


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
W. F. van Rodijnen, I. J. Korstjens, N. Legerstee, P. M. ter Wee, and G.-J. Tangelder
Direct vasoconstrictor effect of prostaglandin E2 on renal interlobular arteries: role of the EP3 receptor
Am J Physiol Renal Physiol, March 1, 2007; 292(3): F1094 - F1101.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
X. C. Li, D. J. Campbell, M. Ohishi, S. Yuan, and J. L. Zhuo
AT1 receptor-activated signaling mediates angiotensin IV-induced renal cortical vasoconstriction in rats
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1024 - F1033.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Stegbauer, V. Oberhauser, O. Vonend, and L. C. Rump
Angiotensin-(1-7) modulates vascular resistance and sympathetic neurotransmission in kidneys of spontaneously hypertensive rats
Cardiovasc Res, February 1, 2004; 61(2): 352 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
I. Haulica, W. Bild, C. N Mihaila, T. Ionita, C. P Boisteanu, and B. Neagu
Biphasic effects of angiotensin (1-7) and its interactions with angiotensin II in rat aorta
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2003; 4(2): 124 - 128.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online