| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Renal Division, Department of Clinical Medicine, University of São Paulo, São Paulo 01246-903, Brazil
The incidence of progressive nephropathies and, consequently, the population suffering from end-stage renal disease have increased steadily in recent years, posing an ever-growing cost, in both human and financial terms, to society. There is mounting evidence that, in both immune-mediated and nonimmune-mediated chronic nephropathies, renal inflammatory events are key to the propagation and perpetuation of renal injury. Mycophenolate mofetil (MMF) is an antilymphocyte agent recently introduced in clinical practice for the prevention of allograft rejection. The present review discusses clinical and experimental evidence that the anti-inflammatory action of MMF can be advantageously used to arrest immune- and nonimmune-mediated progressive injury of native kidneys as well.
immune-mediated nephropathies; nonimmune-mediated nephropathies; kidney failure; chronic; kidney inflammation; lymphocytes
This article has been cited by other articles:
|
|
 |
|
  S. Kramer, E. Binder, T. Loof, Y. Wang-Rosenke, S. Martini, D. Khadzhynov, K. Budde, H.-H. Neumayer, and H. Peters The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy Am J Physiol Renal Physiol, July 1, 2009; 297(1): F218 - F227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Welker, S. Kramer, D. A. Groneberg, H. H. Neumayer, S. Bachmann, K. Amann, and H. Peters Increased mast cell number in human hypertensive nephropathy Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1103 - F1109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dominguez, P. Wu, C. S. Packer, C. Temm, and K. J. Kelly Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy Am J Physiol Renal Physiol, September 1, 2007; 293(3): F670 - F679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Martini, S. Kramer, T. Loof, Y. Wang-Rosenke, U. Daig, K. Budde, H.-H. Neumayer, and H. Peters S1P modulator FTY720 limits matrix expansion in acute anti-thy1 mesangioproliferative glomerulonephritis Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1761 - F1770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kramer, T. Loof, S. Martini, M. Ruckert, Y. Wang, T. Bohler, F. Shimizu, H. Kawachi, H.-H. Neumayer, and H. Peters Mycophenolate mofetil slows progression in anti-thy1-induced chronic renal fibrosis but is not additive to a high dose of enalapril Am J Physiol Renal Physiol, August 1, 2005; 289(2): F359 - F368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Rodriguez-Iturbe, N. D. Vaziri, J. Herrera-Acosta, and R. J. Johnson Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all Am J Physiol Renal Physiol, April 1, 2004; 286(4): F606 - F616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. T. Weber From Inflammation to Fibrosis: A Stiff Stretch of Highway Hypertension, April 1, 2004; 43(4): 716 - 719. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
