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signal transduction and mesangial cell
fibrogenesis
Division of Kidney Diseases, Department of Pediatrics, The Feinberg School of Medicine of Northwestern University, and Children's Memorial Institute for Education and Research, Chicago, Illinois 60611-3008
Transforming growth factor-
(TGF-)
is closely associated with progressive renal fibrosis. Significant
progress has been accomplished in determining the cellular signaling
pathways that are activated by TGF-. This knowledge is being applied
to glomerular mesangial cell models of extracellular matrix (ECM)
accumulation. A central component of TGF--stimulated mesangial cell
fibrogenesis is the TGF- family-specific Smad signal transduction
pathway. However, while Smads play an important role in collagen
accumulation, recent findings indicate that cross talk among a variety
of pathways is necessary for maximal stimulation of collagen
expression. Further investigation of these multiple interactions will
provide insight into possible ways to interrupt cellular mechanisms of
glomerular fibrogenesis.
transforming growth factor-; glomerulosclerosis; Smads
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