AJP - Renal AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 284: F267-F273, 2003. First published October 15, 2002; doi:10.1152/ajprenal.00271.2002
0363-6127/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/F267    most recent
00271.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, H. T.
Right arrow Articles by Emala, C. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, H. T.
Right arrow Articles by Emala, C. W.
Vol. 284, Issue 2, F267-F273, February 2003

A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure

H. Thomas Lee1, Ayuko Ota-Setlik1, Hua Xu1, Vivette D. D'Agati2, Marlene A. Jacobson3, and Charles W. Emala1

1 Department of Anesthesiology and 2 Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032; and 3 Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486

A3 adenosine receptor (AR) activation and inhibition worsen and improve, respectively, renal function after ischemia-reperfusion (I/R) injury in rats. We sought to further characterize the role of A3 ARs in modulating renal function after either I/R or myoglobinuric renal injury. A3 knockout mice had significantly lower plasma creatinines compared with C57 controls 24 h after I/R or myoglobinuric renal injury. C57 control mice pretreated with the A3 AR antagonist [3-ethyl-5-benzyl-2-methyl-4-phenylethynyl-6-phenyl-1,4-(±)-dihydropyridine-3,5 dicarboxylate] or agonist [0.125 mg/kg N6-(3-iodobenzyl)-N-methyl-5'-carbamoyladenosine (IB-MECA)] demonstrated improved or worsened renal function, respectively, after I/R or myoglobinuric renal injury. Higher doses of IB-MECA were lethal in C57 mice subjected to renal ischemia. H1 but not H2 histamine receptor antagonist prevented death in mice pretreated with IB-MECA before renal ischemia. Improvement in renal function was associated with significantly improved renal histology. In conclusion, preischemic A3 AR activation (0.125 mg/kg IB-MECA) exacerbated renal I/R injury in mice. Mice lacking A3 ARs or blocking A3 ARs in wild-type mice resulted in significant renal protection from ischemic or myoglobinuric renal failure.

acute renal failure; histamine; ischemic-reperfusion injury


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
H. T. Lee, S. W. C. Chen, T. C. Doetschman, C. Deng, V. D. D'Agati, and M. Kim
Sevoflurane protects against renal ischemia and reperfusion injury in mice via the transforming growth factor-{beta}1 pathway
Am J Physiol Renal Physiol, July 1, 2008; 295(1): F128 - F136.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Franco, R. Bautista, O. Perez-Mendez, L. Gonzalez, U. Pacheco, L. G. Sanchez-Lozada, J. Santamaria, E. Tapia, R. Monreal, and F. Martinez
Renal interstitial adenosine is increased in angiotensin II-induced hypertensive rats
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F84 - F92.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Grenz, H. Zhang, J. Weingart, S. von Wietersheim, T. Eckle, J. Schnermann, C. Kohle, D. Kloor, C. H. Gleiter, V. Vallon, et al.
Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1501 - F1511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. T. Lee, M. Kim, M. Kim, N. Kim, F. T. Billings IV, V. D. D'Agati, and C. W. Emala Sr.
Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice
Am J Physiol Renal Physiol, September 1, 2007; 293(3): F713 - F722.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
S. K. Jo, M. H. Rosner, and M. D. Okusa
Pharmacologic Treatment of Acute Kidney Injury: Why Drugs Haven't Worked and What Is on the Horizon
Clin. J. Am. Soc. Nephrol., March 1, 2007; 2(2): 356 - 365.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. T. Lee, M. Kim, J. D. Joo, G. Gallos, J.-F. Chen, and C. W. Emala
A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R959 - R969.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
V. Vallon, B. Muhlbauer, and H. Osswald
Adenosine and kidney function.
Physiol Rev, July 1, 2006; 86(3): 901 - 940.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
G. E. McLaughlin, M. D. Alva, and M. Egea
Adenosine receptor antagonism in acute tacrolimus toxicity
Nephrol. Dial. Transplant., July 1, 2006; 21(7): 1961 - 1965.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. T. Lee, H. Xu, S. H. Nasr, J. Schnermann, and C. W. Emala
A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion
Am J Physiol Renal Physiol, February 1, 2004; 286(2): F298 - F306.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online