AJP - Renal Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 284: F389-F398, 2003. First published October 22, 2002; doi:10.1152/ajprenal.00277.2002
0363-6127/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/2/F389    most recent
00277.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, C.
Right arrow Articles by Bang, B. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, C.
Right arrow Articles by Bang, B. K.
Vol. 284, Issue 2, F389-F398, February 2003

Reversibility of chronic cyclosporine nephropathy in rats after withdrawal of cyclosporine

Can Li1,2, Chul Woo Yang1, Wan Young Kim3, Ju Young Jung3, Jung Ho Cha3, Yong Soo Kim1, Jin Kim3, William M. Bennett4, and Byung Kee Bang1

Departments of 1 Internal Medicine and 3 Anatomy, The Catholic University of Korea, Seoul, Korea 137-701; 2 Nephrology and Dialysis Unit, Department of Internal Medicine, Affiliated Hospital, YanBian University Medical College, 133000 YanJi, JiLin, China; and 4 Cellular Transplantation Division, Legacy Good Samaritan Hospital, Portland, Oregon 97210

Renal interstitial inflammation is an important factor in the pathogenesis of chronic cyclosporin A (CsA) nephropathy. We studied the expression of the chemoattractant osteopontin (OPN) and the relationship between OPN expression and tubulointerstitial injury in a rat model of chronic CsA nephropathy. Chronic CsA nephropathy was induced in Sprague-Dawley rats by administering CsA (15 mg/kg sc) for 5 wk and then withdrawing it for 5 or 10 wk. Renal function, histopathology (arteriolopathy, ED-1-positive cells, and tubulointerstitial fibrosis), renin-angiotensin system (RAS) activity, and OPN expression were observed during the follow-up period. Renal function deteriorated in CsA-treated rats, with the development of typical histopathology and activation of RAS. After CsA withdrawal, these parameters were significantly reversed (all P < 0.05). The upregulation of OPN mRNA and protein expression seen in CsA-treated rat kidneys was decreased 5 wk after CsA withdrawal and was further decreased after 10 wk. Of note, OPN mRNA expression correlated with the number of infiltrating macrophage (r = 0.651, P < 0.01) and tubulointerstitial fibrosis (r = 0.729, P < 0.01). These findings suggest that OPN expression and macrophage infiltration decrease after long-term CsA withdrawal in rats with established chronic CsA nephropathy, and this is closely associated with recovery from renal injury.

cyclosporin withdrawal; osteopontin; macrophage; tubulointerstitial fibrosis; renin-angiotensin system


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
I. Tostivint, S. T. du Montcel, M. C. Jaudon, A. Mallet, P. Le Hoang, B. Bodaghi, G. Deray, and C. I. Bagnis
Renal outcome after ciclosporin-induced nephrotoxicity
Nephrol. Dial. Transplant., March 1, 2007; 22(3): 880 - 885.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S.-W. Lim, C. Li, B.-K. Sun, K.-H. Han, W.-Y. Kim, Y.-W. Oh, J.-U. Lee, P. F. Kador, M. A. Knepper, J. M. Sands, et al.
Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney
Am J Physiol Renal Physiol, July 1, 2004; 287(1): F139 - F151.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Li, C. W. Yang, J. H. Park, S. W. Lim, B. K. Sun, J. Y. Jung, S. B. Kim, Y. S. Kim, J. Kim, and B. K. Bang
Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy
Am J Physiol Renal Physiol, January 1, 2004; 286(1): F46 - F57.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online