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Am J Physiol Renal Physiol 284: F518-F524, 2003. First published November 19, 2002; doi:10.1152/ajprenal.00338.2002
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Vol. 284, Issue 3, F518-F524, March 2003

General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system

Hayo Castrop1, Jürgen Klar1, Charlotte Wagner1, Klaus Höcherl2, and Armin Kurtz1

1 Institut für Physiologie und 2 Pharmakologie der Universität Regensburg, D-93040 Regensburg, Germany

Because across-the-board data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel and because ANG II can inhibit COX-2 expression, the purpose of our study was to characterize a potential general inhibitory feedback of the renin-angiotensin system on renocortical COX-2 expression in vivo. Rats were fed a high-, normal-, or low-salt diet or were chronically infused with furosemide (60 mg · kg-1 · day-1) or the left renal artery was clipped, and the animals were treated in addition to or without the angiotensin-converting enzyme inhibitor ramipril (10 mg · kg-1 · day-1). A high-salt diet reduced expression of COX-2, whereas a low-salt diet, furosemide infusion, and renal artery stenosis stimulated COX-2 expression. Additional angiotensin-converting enzyme inhibition led to further increases in renocortical COX-2 expression by 62, 136, 300, 50, and 70% for a high-, normal-, and low-salt diet, furosemide infusion, and renal artery stenosis, respectively. Thus our data suggest a general inhibitory effect of the renin-angiotensin system on renocortical COX-2 expression.

renin; angiotensin-converting enzyme inhibition; renal cortex; prostaglandins


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