| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Program in Membrane Biology and Renal Unit, Department of Medicine, Massachusetts General Hospital, Charlestown 02129, and Harvard Medical School, Boston, Massachusetts 02114
This review outlines recent advances related to the molecular mechanisms and pathways of aquaporin-2 (AQP2) water channel trafficking. AQP2 is a fascinating protein, whose sorting signals can be interpreted by different cell types to achieve apical or basolateral membrane insertion, in both regulated and constitutive trafficking pathways. In addition to the well-known cAMP-mediated, stimulatory effect of vasopressin on AQP2 membrane insertion, other signaling and trafficking events can also lead to AQP2 membrane accumulation via cAMP-independent mechanisms. These include 1) elevation of cGMP, mediated by sodium nitroprusside (a nitric oxide donor), atrial natriuretic factor, and L-arginine (via nitric oxide synthase); 2) disruption of the actin cytoskeleton; and 3) inhibition of the clathrin-mediated endocytotic arm of the AQP2 recycling pathway by dominant-negative dynamin expression and by membrane cholesterol depletion. Recent data also indicate that AQP2 recycles constitutively in epithelial cells, it can be inserted into different membrane domains in different cell types both in vitro and in vivo, and these pathways can be modulated by factors including hypertonicity. The roles of accessory proteins, including small GTPases and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins in AQP2 membrane insertion, are also being uncovered. Understanding cAMP-independent mechanisms for membrane insertion of AQP2 is especially relevant to the therapeutic bypassing of the mutated, dysfunctional vasopressin receptor in patients with X-linked nephrogenic diabetes insipidus.
This article has been cited by other articles:
|
|
 |
|
  Y. Noda, S. Horikawa, E. Kanda, M. Yamashita, H. Meng, K. Eto, Y. Li, M. Kuwahara, K. Hirai, C. Pack, et al. Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking J. Cell Biol., August 11, 2008; 182(3): 587 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Lu, T. Matsuzaki, R. Bouley, U. Hasler, Q.-H. Qin, and D. Brown The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells Am J Physiol Renal Physiol, July 1, 2008; 295(1): F290 - F294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Pastor-Soler, K. R. Hallows, C. Smolak, F. Gong, D. Brown, and S. Breton Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells Am J Physiol Cell Physiol, February 1, 2008; 294(2): C488 - C494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Goel, W. G. Sinkins, C.-D. Zuo, U. Hopfer, and W. P. Schilling Vasopressin-induced membrane trafficking of TRPC3 and AQP2 channels in cells of the rat renal collecting duct Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1476 - F1488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Yool Aquaporins: Multiple Roles in the Central Nervous System Neuroscientist, October 1, 2007; 13(5): 470 - 485. [Abstract] [PDF]
|
|
|
|
 |
|
 R. A. Fenton and M. A. Knepper Mouse Models and the Urinary Concentrating Mechanism in the New Millennium Physiol Rev, October 1, 2007; 87(4): 1083 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Fenton, L. Brond, S. Nielsen, and J. Praetorius Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney Am J Physiol Renal Physiol, September 1, 2007; 293(3): F748 - F760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Reynolds, A. Parris, L. A. Evans, S. Lindqvist, P. Sharp, M. Lewis, R. Tighe, and M. R. Williams Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium J. Physiol., July 15, 2007; 582(2): 507 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Mazzochi, D. J. Benos, and P. R. Smith Interaction of epithelial ion channels with the actin-based cytoskeleton Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1113 - F1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Yang, D. Zhao, L. Qian, and A. S. Verkman Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion Am J Physiol Renal Physiol, August 1, 2006; 291(2): F465 - F472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Russo, M. McKee, and D. Brown Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney Am J Physiol Renal Physiol, July 1, 2006; 291(1): F246 - F253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Boixel, B. Gavillet, J.-S. Rougier, and H. Abriel Aldosterone increases voltage-gated sodium current in ventricular myocytes Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2257 - H2266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Procino, D. B. Caces, G. Valenti, and J. E. Pessin Adipocytes support cAMP-dependent translocation of aquaporin-2 from intracellular sites distinct from the insulin-responsive GLUT4 storage compartment Am J Physiol Renal Physiol, May 1, 2006; 290(5): F985 - F994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Mount Membrane trafficking and the regulation of NKCC2 Am J Physiol Renal Physiol, March 1, 2006; 290(3): F606 - F607. [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Sands and D. G. Bichet Nephrogenic Diabetes Insipidus Ann Intern Med, February 7, 2006; 144(3): 186 - 194. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Da Silva, C. Silberstein, V. Beaulieu, C. Pietrement, A. N. Van Hoek, D. Brown, and S. Breton Postnatal Expression of Aquaporins in Epithelial Cells of the Rat Epididymis Biol Reprod, February 1, 2006; 74(2): 427 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Pastor-Soler, C. Pietrement, and S. Breton Role of Acid/Base Transporters in the Male Reproductive Tract and Potential Consequences of Their Malfunction Physiology, December 1, 2005; 20(6): 417 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. Del Castillo, M. Fedor-Chaiken, J. C. Song, V. Starlinger, J. Yoo, K. S. Matlin, and J. B. Matthews Dynamic regulation of Na+-K+-2Cl- cotransporter surface expression by PKC-{epsilon} in Cl--secretory epithelia Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1332 - C1343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Boursiac, S. Chen, D.-T. Luu, M. Sorieul, N. van den Dries, and C. Maurel Early Effects of Salinity on Water Transport in Arabidopsis Roots. Molecular and Cellular Features of Aquaporin Expression Plant Physiology, October 1, 2005; 139(2): 790 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bouley, N. Pastor-Soler, O. Cohen, M. McLaughlin, S. Breton, and D. Brown Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra) Am J Physiol Renal Physiol, June 1, 2005; 288(6): F1103 - F1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. Kishore, C. M. Krane, R. L. Miller, H. Shi, P. Zhang, A. Hemmert, R. Sun, and R. D. Nelson P2Y2 receptor mRNA and protein expression is altered in inner medullas of hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function Am J Physiol Renal Physiol, June 1, 2005; 288(6): F1164 - F1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Parekh and J. W. Putney Jr. Store-Operated Calcium Channels Physiol Rev, April 1, 2005; 85(2): 757 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Murer, F. Addabbo, M. Carmosino, G. Procino, G. Tamma, G. Montini, W. Rigamonti, P. Zucchetta, M. Della Vella, A. Venturini, et al. Selective Decrease in Urinary Aquaporin 2 and Increase in Prostaglandin E2 Excretion Is Associated with Postobstructive Polyuria in Human Congenital Hydronephrosis J. Am. Soc. Nephrol., October 1, 2004; 15(10): 2705 - 2712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Moshelion, N. Moran, and F. Chaumont Dynamic Changes in the Osmotic Water Permeability of Protoplast Plasma Membrane Plant Physiology, August 1, 2004; 135(4): 2301 - 2317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A.J. Devonald and F. E. Karet Renal Epithelial Traffic Jams and One-Way Streets J. Am. Soc. Nephrol., June 1, 2004; 15(6): 1370 - 1381. [Full Text] [PDF]
|
|
|
|
|
|
J. El Annan, D. Brown, S. Breton, S. Bourgoin, D. A. Ausiello, and V. Marshansky Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ Am J Physiol Cell Physiol, April 1, 2004; 286(4): C768 - C778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Jablonski, A. N. Webb, N. A. McConnell, M. C. Riley, and F. M. Hughes Jr. Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease Am J Physiol Cell Physiol, April 1, 2004; 286(4): C975 - C985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. W. M. van Balkom, J. D. Hoffert, C.-L. Chou, and M. A. Knepper Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat Am J Physiol Renal Physiol, February 1, 2004; 286(2): F216 - F224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lu, T.-X. Sun, R. Bouley, K. Blackburn, M. McLaughlin, and D. Brown Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2 Am J Physiol Renal Physiol, February 1, 2004; 286(2): F233 - F243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Karylowski, A. Zeigerer, A. Cohen, and T. E. McGraw GLUT4 Is Retained by an Intracellular Cycle of Vesicle Formation and Fusion with Endosomes Mol. Biol. Cell, February 1, 2004; 15(2): 870 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Pastor-Soler, V. Beaulieu, T. N. Litvin, N. Da Silva, Y. Chen, D. Brown, J. Buck, L. R. Levin, and S. Breton Bicarbonate-regulated Adenylyl Cyclase (sAC) Is a Sensor That Regulates pH-dependent V-ATPase Recycling J. Biol. Chem., December 5, 2003; 278(49): 49523 - 49529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cuppoletti Continuous flow electrophoresis for study of membrane protein compartments. Focus on "More than apical: distribution of SGLT1 in Caco-2 cells" Am J Physiol Cell Physiol, October 1, 2003; 285(4): C735 - C736. [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Sands Urine-Concentrating Ability in the Aging Kidney Sci. Aging Knowl. Environ., June 18, 2003; 2003(24): pe15 - 15. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
