| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Dorrance Hamilton Research Laboratory, Division of Nephrology, Department of Medicine, and 2 Department of Anatomy, Cell Biology and Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
Diabetic nephropathy is increasing in incidence and is now the number one cause of end-stage renal disease in the industrialized world. To gain insight into the genetic susceptibility and pathophysiology of diabetic nephropathy, an appropriate mouse model of diabetic nephropathy would be critical. A large number of mouse models of diabetes have been identified and their kidney disease characterized to various degrees. Perhaps the best characterized and most intensively investigated model is the db/db mouse. Because this model appears to exhibit the most consistent and robust increase in albuminuria and mesangial matrix expansion, it has been used as a model of progressive diabetic renal disease. In this review, we present the findings from various studies on the renal pathology of the db/db mouse model of diabetes in the context of human diabetic nephropathy. Furthermore, we discuss shortfalls of assessing functional renal disease in mouse models of diabetic kidney disease.
diabetic nephropathy; creatinine; albuminuria; mesangial matrix
This article has been cited by other articles:
|
|
 |
|
  N. Herbach, I. Schairer, A. Blutke, S. Kautz, A. Siebert, B. Goke, E. Wolf, and R. Wanke Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis Am J Physiol Renal Physiol, April 1, 2009; 296(4): F819 - F829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Berthier, H. Zhang, M. Schin, A. Henger, R. G. Nelson, B. Yee, A. Boucherot, M. A. Neusser, C. D. Cohen, C. Carter-Su, et al. Enhanced Expression of Janus Kinase-Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy Diabetes, February 1, 2009; 58(2): 469 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Deji, S. Kume, S.-i. Araki, M. Soumura, T. Sugimoto, K. Isshiki, M. Chin-Kanasaki, M. Sakaguchi, D. Koya, M. Haneda, et al. Structural and functional changes in the kidneys of high-fat diet-induced obese mice Am J Physiol Renal Physiol, January 1, 2009; 296(1): F118 - F126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Park, B. J. Bivona, Y. Feng, E. Lazartigues, and L. M. Harrison-Bernard Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1504 - F1511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B Lemke, A. B Rogers, P. R Nambiar, and J. G Fox Obesity and non-insulin-dependent diabetes mellitus in Swiss-Webster mice associated with late-onset hepatocellular carcinoma J. Endocrinol., October 1, 2008; 199(1): 21 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Soler, J. Wysocki, and D. Batlle Angiotensin-converting enzyme 2 and the kidney Exp Physiol, May 1, 2008; 93(5): 549 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. P. Luttrell, M. Swee, B. Starcher, W. C. Parks, and K. Chitaley Erectile dysfunction in the type II diabetic db/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2204 - H2211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Brezniceanu, F. Liu, C.-C. Wei, I. Chenier, N. Godin, S.-L. Zhang, J. G. Filep, J. R. Ingelfinger, and J. S.D. Chan Attenuation of Interstitial Fibrosis and Tubular Apoptosis in db/db Transgenic Mice Overexpressing Catalase in Renal Proximal Tubular Cells Diabetes, February 1, 2008; 57(2): 451 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Huang, W. A. Border, L. Yu, J. Zhang, D. A. Lawrence, and N. A. Noble A PAI-1 Mutant, PAI-1R, Slows Progression of Diabetic Nephropathy J. Am. Soc. Nephrol., February 1, 2008; 19(2): 329 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Jiang, X. X. Wang, P. Scherzer, P. Wilson, J. Tallman, H. Takahashi, J. Li, M. Iwahashi, E. Sutherland, L. Arend, et al. Farnesoid X Receptor Modulates Renal Lipid Metabolism, Fibrosis, and Diabetic Nephropathy Diabetes, October 1, 2007; 56(10): 2485 - 2493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Barati, M. L. Merchant, A. B. Kain, A. W. Jevans, K. R. McLeish, and J. B. Klein Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1157 - F1165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Menne, J.-K. Park, N. Shushakova, M. Mengel, M. Meier, and D. Fliser The Continuous Erythropoietin Receptor Activator Affects Different Pathways of Diabetic Renal Injury J. Am. Soc. Nephrol., July 1, 2007; 18(7): 2046 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Park, H. W. Kim, S. H. Ko, J. H. Lim, G. R. Ryu, H. W. Chung, S. W. Han, S. J. Shin, B. K. Bang, M. D. Breyer, et al. Long-Term Treatment of Glucagon-Like Peptide-1 Analog Exendin-4 Ameliorates Diabetic Nephropathy through Improving Metabolic Anomalies in db/db Mice J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1227 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Quaggin and T. M. Coffman Toward a Mouse Model of Diabetic Nephropathy: Is Endothelial Nitric Oxide Synthase the Missing Link? J. Am. Soc. Nephrol., February 1, 2007; 18(2): 364 - 366. [Full Text] [PDF]
|
|
|
|
|
|
E. E. Tchekneva, E. M. Rinchik, D. Polosukhina, L. S. Davis, V. Kadkina, Y. Mohamed, S. R. Dunn, K. Sharma, Z. Qi, A. B. Fogo, et al. A Sensitized Screen of N-ethyl-N-nitrosourea-Mutagenized Mice Identifies Dominant Mutants Predisposed to Diabetic Nephropathy J. Am. Soc. Nephrol., January 1, 2007; 18(1): 103 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Juarez, M. M. Vilchis-Landeros, J. Ponce-Coria, V. Mendoza, R. Hernandez-Pando, N. A. Bobadilla, and F. Lopez-Casillas Soluble betaglycan reduces renal damage progression in db/db mice Am J Physiol Renal Physiol, January 1, 2007; 292(1): F321 - F329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kanetsuna, K. Hirano, M. Nagata, M. A. Gannon, K. Takahashi, R. C. Harris, M. D. Breyer, and T. Takahashi Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1315 - F1322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Zhao, S. Wang, H. Cheng, M.-z. Zhang, T. Takahashi, A. B. Fogo, M. D. Breyer, and R. C. Harris Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic Mice J. Am. Soc. Nephrol., October 1, 2006; 17(10): 2664 - 2669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wysocki, M. Ye, M. J. Soler, S. B. Gurley, H. D. Xiao, K. E. Bernstein, T. M. Coffman, S. Chen, and D. Batlle ACE and ACE2 Activity in Diabetic Mice. Diabetes, July 1, 2006; 55(7): 2132 - 2139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Starkey, S. J. Haidacher, W. S. LeJeune, X. Zhang, B. C. Tieu, S. Choudhary, A. R. Brasier, L. A. Denner, and R. G. Tilton Diabetes-Induced Activation of Canonical and Noncanonical Nuclear Factor-{kappa}B Pathways in Renal Cortex. Diabetes, May 1, 2006; 55(5): 1252 - 1259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Z. Levine, M. Iacovitti, S. J. Robertson, and G. A. Mokhtar Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R975 - R981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Sugaru, T. Nakagawa, M. Ono-Kishino, J. Nagamine, T. Tokunaga, M. Kitoh, W. E. Hume, R. Nagata, and M. Taiji SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice Am J Physiol Renal Physiol, April 1, 2006; 290(4): F813 - F820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Galkina and K. Ley Leukocyte Recruitment and Vascular Injury in Diabetic Nephropathy J. Am. Soc. Nephrol., February 1, 2006; 17(2): 368 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Susztak, A. C. Raff, M. Schiffer, and E. P. Bottinger Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy Diabetes, January 1, 2006; 55(1): 225 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Gurley, S. E. Clare, K. P. Snow, A. Hu, T. W. Meyer, and T. M. Coffman Impact of genetic background on nephropathy in diabetic mice Am J Physiol Renal Physiol, January 1, 2006; 290(1): F214 - F222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K.H. Cheung, M. K.L. Fung, A. C.Y. Lo, T. T.L. Lam, K. F. So, S. S.M. Chung, and S. K. Chung Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of db/db Mice Diabetes, November 1, 2005; 54(11): 3119 - 3125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mathew, S. Futterweit, E. Valderrama, A. A. Tarectecan, J. E. Bylander, J. S. Bond, and H. Trachtman Meprin-{alpha} in chronic diabetic nephropathy: interaction with the renin-angiotensin axis Am J Physiol Renal Physiol, October 1, 2005; 289(4): F911 - F921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Qi, H. Fujita, J. Jin, L. S. Davis, Y. Wang, A. B. Fogo, and M. D. Breyer Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy Diabetes, September 1, 2005; 54(9): 2628 - 2637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schiffer, K. Susztak, M. Ranalletta, A. C. Raff, E. P. Bottinger, and M. J. Charron Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions Am J Physiol Renal Physiol, July 1, 2005; 289(1): F186 - F193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Breyer, E. Bottinger, F. C. Brosius III, T. M. Coffman, R. C. Harris, C. W. Heilig, K. Sharma, and for the AMDCC Mouse Models of Diabetic Nephropathy J. Am. Soc. Nephrol., January 1, 2005; 16(1): 27 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zheng, W. T. Noonan, N. S. Metreveli, S. Coventry, P. M. Kralik, E. C. Carlson, and P. N. Epstein Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice Diabetes, December 1, 2004; 53(12): 3248 - 3257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sahai, P. Malladi, X. Pan, R. Paul, H. Melin-Aldana, R. M. Green, and P. F. Whitington Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin Am J Physiol Gastrointest Liver Physiol, November 1, 2004; 287(5): G1035 - G1043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mishra, S. N. Emancipator, C. Miller, T. Kern, and M. S. Simonson Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney Am J Physiol Renal Physiol, May 1, 2004; 286(5): F913 - F921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ye, J. Wysocki, P. Naaz, M. R. Salabat, M. S. LaPointe, and D. Batlle Increased ACE 2 and Decreased ACE Protein in Renal Tubules From Diabetic Mice: A Renoprotective Combination? Hypertension, May 1, 2004; 43(5): 1120 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Susztak, E. Bottinger, A. Novetsky, D. Liang, Y. Zhu, E. Ciccone, D. Wu, S. Dunn, P. McCue, and K. Sharma Molecular Profiling of Diabetic Mouse Kidney Reveals Novel Genes Linked to Glomerular Disease Diabetes, March 1, 2004; 53(3): 784 - 794. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
