AJP - Renal Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 285: F121-F129, 2003. First published March 25, 2003; doi:10.1152/ajprenal.00241.2002
0363-6127/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/1/F121    most recent
00241.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wetzel, R. K.
Right arrow Articles by Sweadner, K. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wetzel, R. K.
Right arrow Articles by Sweadner, K. J.

Phospholemman expression in extraglomerular mesangium and afferent arteriole of the juxtaglomerular apparatus

Randall K. Wetzel and Kathleen J. Sweadner

Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129

Submitted 3 July 2002 ; accepted in final form 17 March 2003

The molecular mechanisms with which the juxtaglomerular apparatus accomplishes its twin functions, acute regulation of glomerular blood flow and secretion of renin, are still not clearly understood. Least understood is the role of the extraglomerular mesangial (EM) cells, also known as lacis or Goormaghtigh cells, which lie sandwiched between the macula densa and the afferent and efferent arterioles. Here, we report that immunoreactivity for phospholemman (FXYD1), a single-span membrane protein homologous to the gamma ({gamma}) sub-unit of the Na,K-ATPase, is found in the kidney in EM cells with the Na,K-ATPase {beta}2-subunit and in cortical blood vessels and the afferent arteriole with Na,K-ATPase {alpha}2 and {beta}2. Phospholemman's distribution in EM cells is distinct from that of the Na,K-ATPase {gamma}-subunit, which is found on the basolateral surface of macula densa cells with Na,K-ATPase {alpha}1 and {beta}1. Phospholemman is a major kinase target, and its location in the juxtaglomerular apparatus suggests that it is involved in tubuloglomerular feedback.

glomerulus; renin; macula densa; Na,K-ATPase; FXYD


Address for reprint requests and other correspondence: K. J. Sweadner, 149-6118, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129 (E-mail: sweadner{at}helix.mgh.harvard.edu).




This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
E. Arystarkhova, C. Donnet, A. Munoz-Matta, S. C. Specht, and K. J. Sweadner
Multiplicity of expression of FXYD proteins in mammalian cells: dynamic exchange of phospholemman and {gamma}-subunit in response to stress
Am J Physiol Cell Physiol, March 1, 2007; 292(3): C1179 - C1191.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Lifshitz, M. Lindzen, H. Garty, and S. J. D. Karlish
Functional Interactions of Phospholemman (PLM) (FXYD1) with Na+,K+-ATPase: PURIFICATION OF {alpha}1/beta1/PLM COMPLEXES EXPRESSED IN PICHIA PASTORIS
J. Biol. Chem., June 9, 2006; 281(23): 15790 - 15799.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. Geering
FXYD proteins: new regulators of Na-K-ATPase
Am J Physiol Renal Physiol, February 1, 2006; 290(2): F241 - F250.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. Dostanic, R. J. Paul, J. N. Lorenz, S. Theriault, J. W. Van Huysse, and J. B. Lingrel
The {alpha}2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro
Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H477 - H485.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.