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Am J Physiol Renal Physiol 285: F121-F129, 2003. First published March 25, 2003; doi:10.1152/ajprenal.00241.2002
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Phospholemman expression in extraglomerular mesangium and afferent arteriole of the juxtaglomerular apparatus

Randall K. Wetzel and Kathleen J. Sweadner

Laboratory of Membrane Biology, Neuroscience Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129

Submitted 3 July 2002 ; accepted in final form 17 March 2003

The molecular mechanisms with which the juxtaglomerular apparatus accomplishes its twin functions, acute regulation of glomerular blood flow and secretion of renin, are still not clearly understood. Least understood is the role of the extraglomerular mesangial (EM) cells, also known as lacis or Goormaghtigh cells, which lie sandwiched between the macula densa and the afferent and efferent arterioles. Here, we report that immunoreactivity for phospholemman (FXYD1), a single-span membrane protein homologous to the gamma ({gamma}) sub-unit of the Na,K-ATPase, is found in the kidney in EM cells with the Na,K-ATPase {beta}2-subunit and in cortical blood vessels and the afferent arteriole with Na,K-ATPase {alpha}2 and {beta}2. Phospholemman's distribution in EM cells is distinct from that of the Na,K-ATPase {gamma}-subunit, which is found on the basolateral surface of macula densa cells with Na,K-ATPase {alpha}1 and {beta}1. Phospholemman is a major kinase target, and its location in the juxtaglomerular apparatus suggests that it is involved in tubuloglomerular feedback.

glomerulus; renin; macula densa; Na,K-ATPase; FXYD


Address for reprint requests and other correspondence: K. J. Sweadner, 149-6118, Massachusetts General Hospital, 149 13th St., Charlestown, MA 02129 (E-mail: sweadner{at}helix.mgh.harvard.edu).




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