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Johannes Müller Institut für Physiologie, Humboldt-Universität (Charité), 10117 Berlin, Germany
Submitted 5 December 2002 ; accepted in final form 18 June 2003
Response of renal vasculature to changes in renal perfusion pressure (RPP)
involves mechanisms with different frequency characteristics. Autoregulation
of renal blood flow (RBF) is mediated by the rapid myogenic response, by the
slower tubuloglomerular feedback (TGF) mechanism, and, possibly, by an even
slower third mechanism. To evaluate the individual contribution of these
mechanisms to RBF autoregulation, we analyzed the response of RBF to a step
increase in RPP. In anesthetized rats, the suprarenal aorta was occluded for
30 s, and then the occlusion was released to induce a step increase in RPP.
Three dampened oscillations were observed; their oscillation periods ranged
from 9.5 to 13 s, from 34.2 to 38.6 s, and from 100.5 to 132.2 s,
respectively. The two faster oscillations correspond with previously reported
data on the myogenic mechanism and the TGF. In accordance, after furosemide,
the amplitude of the intermediate oscillation was significantly reduced.
Inhibition of nitric oxide synthesis by
N
-nitro-L-arginine methyl ester
significantly increased the amplitude of the 10-s oscillation. It is concluded
that the parameters of the dampened oscillations induced by the step increase
in RPP reflect properties of autoregulatory mechanisms. The oscillation period
characterizes the individual mechanism, the dampening is a measure for the
stability of the regulation, and the square of the amplitudes characterizes
the power of the respective mechanism. In addition to the myogenic response
and the TGF, a third rather slow mechanism of RBF autoregulation exists.
myogenic reaction; tubuloglomerular feedback; furosemide; N-nitro-L-arginine methyl ester
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