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Am J Physiol Renal Physiol 285: F833-F842, 2003; doi:10.1152/ajprenal.00088.2003
0363-6127/03 $5.00
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INVITED REVIEW

Noncoordinate regulation of ENaC: paradigm lost?

Ora A. Weisz and John P. Johnson

Laboratory of Epithelial Cell Biology, Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

The epithelial sodium channel (ENaC) is composed of the three homologous subunits {alpha}, {beta}, and {gamma}. The basic oligomerization process inferred from all studies in heterologous systems is preferential assembly of the three subunits into a single oligomeric form. However, there is also considerable evidence that channels composed of only {alpha}-, {alpha}{beta}-, or {alpha}{gamma}-subunits can form under some circumstances and that individual subunits expressed in heterologous systems can traffic to the cell membrane. In cells that express endogenous ENaC, the three subunits are often synthesized in a differential fashion, with one or two subunits expressed constitutively while the other(s) are induced by different physiological stimuli in parallel with increased ENaC activity. This phenomenon, which we term noncoordinate regulation, has been observed for both whole cell and apical membrane ENaC subunit expression. Several other heteromeric membrane proteins have also been observed to have differential rates of either turnover or trafficking of individual subunits after biosynthesis and membrane localization. Here, we examine the possibility that noncoordinate regulation of ENaC subunits may represent another mechanism in the arsenal of physiological responses to diverse stimuli.

epithelial sodium channel; trafficking; aldosterone; T cell antigen receptor; assembly


Address for reprint requests and other correspondence: O. A. Weisz, Renal-Electrolyte Div., Dept. of Medicine, Univ. of Pittsburgh, 978 Scaife Hall, 3550 Terrace St., Pittsburgh, PA 15261 (E-mail: weisz{at}pitt.edu).




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