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Am J Physiol Renal Physiol 286: F26-F37, 2004. First published September 16, 2003; doi:10.1152/ajprenal.00099.2003
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Low endogenous glucocorticoid allows induction of kidney cortical cyclooxygenase-2 during postnatal rat development

Kirsten Madsen,1 Jane Stubbe,1 Tianxin Yang,2 Ole Skøtt,1 Sebastian Bachmann,3 and Boye L. Jensen1

1Department of Physiology and Pharmacology, University of Southern Denmark, DK-5000 Odense, Denmark; 2Division of Nephrology, University of Utah School of Medicine, and Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah 84132; and 3Department of Anatomy, Charité, Humboldt University, 10115 Berlin, Germany

Submitted 7 March 2003 ; accepted in final form 11 September 2003

In postnatal weeks 2–4, cyclooxygenase-2 (COX-2) is induced in the rat kidney cortex where it is critically involved in final stages of kidney development. We examined whether changes in circulating gluco- or mineralocorticosteroids or in their renal receptors regulate postnatal COX-2 induction. Plasma corticosterone concentration peaked at birth, decreased to low levels at days 3-13, and increased to adult levels from day 22. Aldosterone peaked at birth and then stabilized at adult levels. Gluco- and mineralocorticoid receptor (GR and MR) mRNAs were expressed stably in kidney before, during, and after COX-2 induction. 11{beta}-Hydroxysteroid dehydrogenase 2 was induced shortly after birth and was widely distributed in the whole collecting duct system in the suckling period and then returned to an adult pattern. Supplementation with corticosterone (20 mg·kg-1·day-1) or GR-specific dexamethasone (1 mg·kg-1·day-1) during low endogenous corticosterone suppressed renal COX-2 mRNA and protein and led to a restricted distribution of COX-2 immunolabeling. The ability of glucocorticoids to affect COX-2 was reflected in colocalization of GR-{alpha} and COX-2 immunoreactivity and mRNAs in thick ascending limb of Henle's loop. The MR antagonist potassium canrenoate (20 mg·kg-1·day-1) enhanced COX-2 expression from days 5 to 10, but low MR-specific concentrations of DOCA (1 mg·kg-1·day-1) had no effect on COX-2. Renomedullary interstitial cells expressed GR-{alpha} and COX-2. Dexamethasone suppressed COX-2 in these cells. Thus low plasma concentrations of corticosterone allowed for cortical and medullary COX-2 induction during postnatal kidney development. Increased circulating glucocorticoid in the postnatal period may damage late renal development through inhibition of COX-2.

mineralocorticoid; aldosterone; 11{beta}-hydroxysteroid dehydrogenase 2; nephrogenesis; prostaglandin


Address for reprint requests and other correspondence: B. L. Jensen, Dept. of Physiology and Pharmacology, Univ. of Southern Denmark, Winsløw-parken 21, 3, DK-5000 Odense C, Denmark (E-mail: bljensen{at}health.sdu.dk).




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