AJP - Renal Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 286: F1063-F1071, 2004. First published January 13, 2004; doi:10.1152/ajprenal.00384.2003
0363-6127/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
286/6/F1063    most recent
00384.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (48)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, W. Y.
Right arrow Articles by Yu, A. S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, W. Y.
Right arrow Articles by Yu, A. S. L.

Expression of claudin-7 and -8 along the mouse nephron

Wing Y. Li, Catherine L. Huey, and Alan S. L. Yu

Division of Nephrology, Department of Medicine, and Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California 90033

Submitted 31 October 2003 ; accepted in final form 8 January 2004

Claudins are integral membrane proteins of the tight junction that determine the magnitude and selectivity of paracellular permeability in epithelial tissues. The mammalian renal tubule exhibits considerable heterogeneity in the permeability properties of its different segments. To determine the nephron segment localization of claudin-7 and -8, immunofluorescence staining of mouse kidney sections was performed using isoform-specific antibodies. Claudin-8 was found to be expressed primarily at the tight junction along the entire aldosterone-sensitive distal nephron and in the late segments of the thin descending limbs of long-looped nephrons. This pattern of expression is consistent with the putative role of claudin-8 as a paracellular cation barrier. By contrast, claudin-7 was found in the same nephron segments as claudin-8, but it was expressed primarily at the basolateral membrane.

tight junction; paracellular transport; immunofluorescence; renal tubule


Address for reprint requests and other correspondence: A. S. L. Yu, Univ. of Southern California Keck School of Medicine, Div. of Nephrology, 2025 Zonal Ave, RMR 406, Los Angeles, CA 90033 (E-mail: alanyu{at}usc.edu).




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Angelow, R. Ahlstrom, and A. S. L. Yu
Biology of claudins
Am J Physiol Renal Physiol, October 1, 2008; 295(4): F867 - F876.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Darido, M. Buchert, J. Pannequin, P. Bastide, H. Zalzali, T. Mantamadiotis, J.-F. Bourgaux, V. Garambois, P. Jay, P. Blache, et al.
Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells
Cancer Res., June 1, 2008; 68(11): 4258 - 4268.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Zhao, E. Yaoita, M. Nameta, Y. Zhang, L. M. Cuellar, H. Fujinaka, B. Xu, Y. Yoshida, K. Hatakeyama, and T. Yamamoto
Claudin-6 localized in tight junctions of rat podocytes
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1856 - R1862.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. K. Tipsmark, D. A. Baltzegar, O. Ozden, B. J. Grubb, and R. J. Borski
Salinity regulates claudin mRNA and protein expression in the teleost gill
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R1004 - R1014.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Angelow, R. El-Husseini, S. A. Kanzawa, and A. S. L. Yu
Renal localization and function of the tight junction protein, claudin-19
Am J Physiol Renal Physiol, July 1, 2007; 293(1): F166 - F177.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Abuazza, A. Becker, S. S. Williams, S. Chakravarty, H.-T. Truong, F. Lin, and M. Baum
Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1132 - F1141.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. M. Van Itallie, S. Rogan, A. Yu, L. S. Vidal, J. Holmes, and J. M. Anderson
Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1288 - F1299.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
L. Gonzalez-Mariscal, M. Del CarmenNamorado, D. Martin, G. Sierra, and J. L. Reyes
The tight junction proteins claudin-7 and -8 display a different subcellular localization at Henle's loops and collecting ducts of rabbit kidney
Nephrol. Dial. Transplant., September 1, 2006; 21(9): 2391 - 2398.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
H. Fujita, H. Chiba, H. Yokozaki, N. Sakai, K. Sugimoto, T. Wada, T. Kojima, T. Yamashita, and N. Sawada
Differential Expression and Subcellular Localization of Claudin-7, -8, -12, -13, and -15 Along the Mouse Intestine
J. Histochem. Cytochem., August 1, 2006; 54(8): 933 - 944.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. F. Balkovetz
Claudins at the gate: determinants of renal epithelial tight junction paracellular permeability
Am J Physiol Renal Physiol, March 1, 2006; 290(3): F572 - F579.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Angelow, K.-J. Kim, and A. S. L. Yu
Claudin-8 modulates paracellular permeability to acidic and basic ions in MDCK II cells
J. Physiol., February 15, 2006; 571(1): 15 - 26.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
X.-Y. Zhai, J. S. Thomsen, H. Birn, I. B. Kristoffersen, A. Andreasen, and E. I. Christensen
Three-Dimensional Reconstruction of the Mouse Nephron
J. Am. Soc. Nephrol., January 1, 2006; 17(1): 77 - 88.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. Le Moellic, S. Boulkroun, D. Gonzalez-Nunez, I. Dublineau, F. Cluzeaud, M. Fay, M. Blot-Chabaud, and N. Farman
Aldosterone and tight junctions: modulation of claudin-4 phosphorylation in renal collecting duct cells
Am J Physiol Cell Physiol, December 1, 2005; 289(6): C1513 - C1521.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Carrozzino, P. Soulie, D. Huber, N. Mensi, L. Orci, A. Cano, E. Feraille, and R. Montesano
Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins
Am J Physiol Cell Physiol, October 1, 2005; 289(4): C1002 - C1014.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. D. Alexandre, Q. Lu, and Y.-H. Chen
Overexpression of claudin-7 decreases the paracellular Cl- conductance and increases the paracellular Na+ conductance in LLC-PK1 cells
J. Cell Sci., June 15, 2005; 118(12): 2683 - 2693.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. S. L. Yu, K. M. McCarthy, S. A. Francis, J. M. McCormack, J. Lai, R. A. Rogers, R. D. Lynch, and E. E. Schneeberger
Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells
Am J Physiol Cell Physiol, June 1, 2005; 288(6): C1231 - C1241.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. M. Van Itallie, T. M. Gambling, J. L. Carson, and J. M. Anderson
Palmitoylation of claudins is required for efficient tight-junction localization
J. Cell Sci., April 1, 2005; 118(7): 1427 - 1436.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
C. M. Van Itallie and J. M. Anderson
The Molecular Physiology of Tight Junction Pores
Physiology, December 1, 2004; 19(6): 331 - 338.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. Acharya, J. Beckel, W. G. Ruiz, E. Wang, R. Rojas, L. Birder, and G. Apodaca
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium
Am J Physiol Renal Physiol, August 1, 2004; 287(2): F305 - F318.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.