AJP - Renal Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 287: F347-F352, 2004; doi:10.1152/ajprenal.00159.2004
0363-6127/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (31)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Korstanje, R.
Right arrow Articles by DiPetrillo, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Korstanje, R.
Right arrow Articles by DiPetrillo, K.

INVITED REVIEW

Unraveling the genetics of chronic kidney disease using animal models

Ron Korstanje1,2 and Keith DiPetrillo1

1The Jackson Laboratory, Bar Harbor, Maine 04609; and 2Department of Pathology and Laboratory Medicine, Groningen University, 9713 GZ Groningen, The Netherlands

Identifying genes underlying common forms of kidney disease in humans has proven difficult, expensive, and time consuming. Quantitative trait loci (QTL) for several complex traits are concordant among mice, rats, and humans, suggesting that genetic findings from these animal models are relevant to human disease. Therefore, we reviewed the literature on genetic studies of kidney disease in rat and mouse and examined the concordance between kidney disease QTL across species. Fifteen genomic regions contribute to kidney disease in the rat, with 12 replicated either in a separate rat cross or in another species. Five loci found in humans were concordant to QTL found in the rat. Two of these were found by homology to a previously identified rat QTL on chromosome 1, demonstrating that kidney disease loci in animal models can predict the location of kidney disease loci in humans. In contrast to the rat, the mouse has been underutilized in the genetic analysis of polygenic kidney disease, although mutagenesis and QTL analysis in the mouse are likely to contribute new findings in the near future. Knowledge of kidney disease loci conserved between the mouse and rat will identify prime candidate loci to test for association with chronic kidney disease in humans.

mouse; rat; human; quantitative trait loci; concordance


Address for reprint requests and other correspondence: K. DiPetrillo, The Jackson Laboratory, 600 Main St., Box 74, Bar Harbor, ME 04609 (E-mail: kjd{at}jax.org)




This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
I. Aneas, M. V. Rodrigues, B. A. Pauletti, G. J. J. Silva, R. Carmona, L. Cardoso, A. E. Kwitek, H. J. Jacob, J. M. P. Soler, and J. E. Krieger
Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR
Physiol Genomics, March 3, 2009; 37(1): 52 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
D. H. T. IJpelaar, A. Schulz, J. Aben, A. van der Wal, J. A. Bruijn, R. Kreutz, and E. de Heer
Genetic predisposition for glomerulonephritis-induced glomerulosclerosis in rats is linked to chromosome 1
Physiol Genomics, October 8, 2008; 35(2): 173 - 181.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. Doorenbos, S.-W. Tsaih, S. Sheehan, N. Ishimori, G. Navis, G. Churchill, K. DiPetrillo, and R. Korstanje
Quantitative Trait Loci for Urinary Albumin in Crosses Between C57BL/6J and A/J Inbred Mice in the Presence and Absence of Apoe
Genetics, May 1, 2008; 179(1): 693 - 699.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. L. Mattson, M. R. Dwinell, A. S. Greene, A. E. Kwitek, R. J. Roman, A. W. Cowley Jr., and H. J. Jacob
Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats
Am J Physiol Renal Physiol, December 1, 2007; 293(6): F1905 - F1914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Sheehan, S.-W. Tsaih, B. L. King, C. Stanton, G. A. Churchill, B. Paigen, and K. DiPetrillo
Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1649 - F1656.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. Aigner, B. Rathkolb, N. Herbach, E. Kemter, C. Schessl, M. Klaften, M. Klempt, M. H. de Angelis, R. Wanke, and E. Wolf
Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models
Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1560 - F1567.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
P. E. C. Brenchley, B. Lindholm, F. W. Dekker, G. Navis, and on behalf of the Renal Genome Network
Translating knowledge of the human genome into clinical practice in nephrology dialysis and transplantation: the renal genome network (ReGeNet)
Nephrol. Dial. Transplant., October 1, 2006; 21(10): 2681 - 2683.
[Full Text] [PDF]

Home page
 J. Lipid Res.Home page
H. Wittenburg, M. A. Lyons, R. Li, U. Kurtz, X. Wang, J. Mossner, G. A. Churchill, M. C. Carey, and B. Paigen
QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains,
J. Lipid Res., August 1, 2006; 47(8): 1780 - 1790.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. T. Turner, S. L.R. Kardia, T. H. Mosley, A. D. Rule, E. Boerwinkle, and M. de Andrade
Influence of Genomic Loci on Measures of Chronic Kidney Disease in Hypertensive Sibships
J. Am. Soc. Nephrol., July 1, 2006; 17(7): 2048 - 2055.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. Lopez, R. P. Ryan, C. Moreno, A. Sarkis, J. Lazar, A. P. Provoost, H. J. Jacob, and R. J. Roman
Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1213 - F1221.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. R. Garrett, B. Joe, and S. Yerga-Woolwine
Genetic linkage of urinary albumin excretion in Dahl salt-sensitive rats: influence of dietary salt and confirmation using congenic strains.
Physiol Genomics, March 13, 2006; 25(1): 39 - 49.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. P. Winn, N. Daskalakis, R. F. Spurney, and J. P. Middleton
Unexpected Role of TRPC6 Channel in Familial Nephrotic Syndrome: Does It Have Clinical Implications?
J. Am. Soc. Nephrol., February 1, 2006; 17(2): 378 - 387.
[Full Text] [PDF]

Home page
 Genome ResHome page
J. Lazar, C. Moreno, H. J. Jacob, and A. E. Kwitek
Impact of genomics on research in the rat
Genome Res., December 1, 2005; 15(12): 1717 - 1728.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. L. Mattson, M. P. Kunert, R. J. Roman, H. J. Jacob, and A. W. Cowley Jr.
Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat
Am J Physiol Renal Physiol, May 1, 2005; 288(5): F1015 - F1022.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. Rangel-Filho, M. Sharma, Y. H. Datta, C. Moreno, R. J. Roman, Y. Iwamoto, A. P. Provoost, J. Lazar, and H. J. Jacob
Rf-2 Gene Modulates Proteinuria and Albuminuria Independently of Changes in Glomerular Permeability in the Fawn-Hooded Hypertensive Rat
J. Am. Soc. Nephrol., April 1, 2005; 16(4): 852 - 856.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.