| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Indiana Center for Biological Microscopy, Department of Medicine, Division of Nephrology, Indiana University, Indianapolis, Indiana 46202
Submitted 12 February 2004 ; accepted in final form 27 May 2004
Tetracyclines exhibit significant anti-inflammatory properties in a variety of rheumatologic and dermatologic conditions. They have also been shown to inhibit apoptosis in certain neurodegenerative disorders. Because ischemic renal injury is characterized by both apoptosis and inflammation, we investigated the therapeutic potential of tetracyclines in a rat model of renal ischemia-reperfusion. Male Sprague-Dawley rats underwent bilateral renal artery clamp for 30 min followed by reperfusion and received either minocycline or saline for 36 h before ischemia. Minocycline reduced tubular cell apoptosis 24 h after ischemia as determined by terminal transferase-mediated dUTP nick end-labeling staining and nuclear morphology. It also decreased cytochrome c release into the cytoplasm and reduced upregulation of p53 and Bax after ischemia. The minocycline-treated group showed a significant reduction in tubular injury and cast formation. In addition, minocycline reduced the number of infiltrating leukocytes, decreased leukocyte chemotaxis both in vitro and ex vivo, and downregulated the expression of ICAM-1. Serum creatinine 24-h postischemia was significantly reduced in the minocycline-treated group. We conclude that minocycline has potent antiapoptotic and anti-inflammatory properties and protects renal function in this model of ischemia-reperfusion. Tetracyclines are among the safest and best-studied antibiotics. They are thus attractive candidates for the therapy of human ischemic acute renal failure.
tetracyclines; acute renal failure; cytochrome c; p53
This article has been cited by other articles:
|
|
 |
|
  S. Bengatta, C. Arnould, E. Letavernier, M. Monge, H. M. de Preneuf, Z. Werb, P. Ronco, and B. Lelongt MMP9 and SCF Protect from Apoptosis in Acute Kidney Injury J. Am. Soc. Nephrol., April 1, 2009; 20(4): 787 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hudson, J. Hudson, M. Swaminathan, A. Shaw, M. Stafford-Smith, and U. D. Patel Emerging Concepts in Acute Kidney Injury Following Cardiac Surgery Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2008; 12(4): 320 - 330. [Abstract] [PDF]
|
|
|
|
 |
|
 T. A. Sutton, J. Wilkinson, H. E. Mang, N. L. Knipe, Z. Plotkin, M. Hosein, K. Zak, J. Wittenborn, and P. C. Dagher p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury Am J Physiol Renal Physiol, December 1, 2008; 295(6): F1666 - F1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Kelly, P. Wu, C. E. Patterson, C. Temm, and J. H. Dominguez LOX-1 and inflammation: a new mechanism for renal injury in obesity and diabetes Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1136 - F1145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kindt, A. Menzebach, M. Van de Wouwer, I. Betz, A. De Vriese, and E. M. Conway Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure FASEB J, February 1, 2008; 22(2): 510 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. El-Achkar, Z. Plotkin, B. Marcic, and P. C. Dagher Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1187 - F1196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Jo, M. H. Rosner, and M. D. Okusa Pharmacologic Treatment of Acute Kidney Injury: Why Drugs Haven't Worked and What Is on the Horizon Clin. J. Am. Soc. Nephrol., March 1, 2007; 2(2): 356 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kroemer, L. Galluzzi, and C. Brenner Mitochondrial Membrane Permeabilization in Cell Death Physiol Rev, January 1, 2007; 87(1): 99 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Devarajan Update on Mechanisms of Ischemic Acute Kidney Injury J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1503 - 1520. [Full Text] [PDF]
|
|
|
|
 |
|
 W. Masocha, M. E. Rottenberg, and K. Kristensson Minocycline impedes african trypanosome invasion of the brain in a murine model. Antimicrob. Agents Chemother., May 1, 2006; 50(5): 1798 - 1804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. El-Achkar, X. Huang, Z. Plotkin, R. M. Sandoval, G. J. Rhodes, and P. C. Dagher Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1034 - F1043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wei, X.-M. Yin, M.-H. Wang, and Z. Dong Bid deficiency ameliorates ischemic renal failure and delays animal death in C57BL/6 mice Am J Physiol Renal Physiol, January 1, 2006; 290(1): F35 - F42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brooks, P. Ketsawatsomkron, Y. Sui, J. Wang, C.-Y. Wang, F.-S. Yu, and Z. Dong Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome Am J Physiol Renal Physiol, August 1, 2005; 289(2): F410 - F419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Sutton, K. J. Kelly, H. E. Mang, Z. Plotkin, R. M. Sandoval, and P. C. Dagher Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury Am J Physiol Renal Physiol, January 1, 2005; 288(1): F91 - F97. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
