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Am J Physiol Renal Physiol 287: F864-F865, 2004; doi:10.1152/classicessays.00005.2004
0363-6127/04 $5.00

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EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

Two classic papers in acid-base physiology: contributions of R. F. Pitts, R. S. Alexander, and W. D. Lotspeich

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520-8026

ABSTRACT

This essay looks at the historical significance of two APS classic papers that are freely available online:

Pitts RF and Alexander RS. The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol 144: 239—254, 1945 (http://ajplegacy.physiology.org/cgi/reprint/144/2/239).

Pitts RF and Lotspeich WD. Bicarbonate and the renal regulation of acid base balance. Am J Physiol 147: 138—154, 1946 (http://ajplegacy.physiology.org/cgi/reprint/147/1/138).