| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York; 2Department of Nephrology, The Chang Gung Memorial Hospital, Taiwan, Republic of China; 3Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island; and 4Department of Physiology and Biophysics, University of South Florida, Tampa, Florida
Submitted 4 May 2004 ; accepted in final form 10 October 2004
We have previously shown that there are two oscillating components in spontaneously fluctuating single-nephron blood flow obtained from Sprague-Dawley rats (Yip K-P, Holstein-Rathlou NH, and Marsh DJ. Am J Physiol Renal Physiol 264: F427–F434, 1993). The slow oscillation (20–30 mHz) is mediated by tubuloglomerular feedback (TGF), whereas the fast oscillation (100 mHz) is probably related to spontaneous myogenic activity. The fast oscillation is rarely detected in spontaneous tubular pressure because of its small magnitude and the fact that tubular compliance filters pressure waves. We detected myogenic oscillation superimposed on TGF-mediated oscillation when ambient tubular flow was interrupted. Two well-defined peaks are present in the mean power spectrum of stop-flow pressure (SFP) centering at 25 and 100 mHz (n = 13), in addition to a small peak at 125–130 mHz. Bispectral analysis indicates that two of these oscillations (30 and 100 mHz) interact nonlinearly to produce the third oscillation at 125–130 mHz. The presence of nonlinear interactions between TGF and myogenic oscillations indicates that estimates of the relative contribution of each of these mechanisms in renal autoregulation need to account for this interaction. The magnitude of myogenic oscillations was considerably smaller in the SFP measured from spontaneously hypertensive rats (SHR, n = 13); consequently, nonlinear interactions were not observed with bispectral analysis. Reduced augmentation of myogenic oscillations in SFP of SHR might account for the failure in detecting nonlinear interactions in SHR.
bispectrum; autoregressive; bicoherence; nonlinear interactions; hypertensive; tubuloglomerular feedback
This article has been cited by other articles:
|
|
 |
|
  D. J. Marsh, I. Toma, O. V. Sosnovtseva, J. Peti-Peterdi, and N.-H. Holstein-Rathlou Electrotonic vascular signal conduction and nephron synchronization Am J Physiol Renal Physiol, April 1, 2009; 296(4): F751 - F761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Chon, Y. Zhong, L. C. Moore, N. H. Holstein-Rathlou, and W. A. Cupples Analysis of nonstationarity in renal autoregulation mechanisms using time-varying transfer and coherence functions Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R821 - R828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Iliescu, R. Cazan, G. R. McLemore Jr., M. Venegas-Pont, and M. J. Ryan Renal blood flow and dynamic autoregulation in conscious mice Am J Physiol Renal Physiol, September 1, 2008; 295(3): F734 - F740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takenaka, T. Inoue, Y. Kanno, H. Okada, C. E. Hill, and H. Suzuki Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R1 - R11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhong, Y. Bai, B. Yang, K. Ju, K. Shin, M. Lee, K.-M. Jan, and K. H. Chon Autonomic nervous nonlinear interactions lead to frequency modulation between low- and high-frequency bands of the heart rate variability spectrum Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1961 - R1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. V. Sosnovtseva, A. N. Pavlov, E. Mosekilde, K.-P. Yip, N.-H. Holstein-Rathlou, and D. J. Marsh Synchronization among mechanisms of renal autoregulation is reduced in hypertensive rats Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1545 - F1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Balasubramanian, A. Ahmed, C.-M. Lo, J. S. K. Sham, and K.-P. Yip Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: activation of calcium sparks Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1586 - R1594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples and B. Braam Assessment of renal autoregulation Am J Physiol Renal Physiol, April 1, 2007; 292(4): F1105 - F1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Just Mechanisms of renal blood flow autoregulation: dynamics and contributions Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R1 - R17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Layton, L. C. Moore, and H. E. Layton Multistability in tubuloglomerular feedback and spectral complexity in spontaneously hypertensive rats Am J Physiol Renal Physiol, July 1, 2006; 291(1): F79 - F97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takenaka, H. Okada, Y. Kanno, T. Inoue, M. Ryuzaki, H. Nakamoto, H. Kawachi, F. Shimizu, and H. Suzuki Exogenous 5'-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats Am J Physiol Renal Physiol, April 1, 2006; 290(4): F844 - F853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Raghavan, X. Chen, K.-P. Yip, D. J. Marsh, and K. H. Chon Interactions between TGF-dependent and myogenic oscillations in tubular pressure and whole kidney blood flow in both SDR and SHR Am J Physiol Renal Physiol, March 1, 2006; 290(3): F720 - F732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Marsh, O. V. Sosnovtseva, A. N. Pavlov, K.-P. Yip, and N.-H. Holstein-Rathlou Frequency encoding in renal blood flow regulation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1160 - R1167. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
