| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
INVITED REVIEW
1Division of Nephrology and Hypertension, Departments of Medicine and Biochemistry and Molecular Biology, Mayo Clinic Rochester, Mayo College of Medicine, Rochester, Minnesota; and 2Receptor Ligand Therapeutics, Genzyme Corporation, Framingham, Massachusetts
Phosphate ions are critical for normal bone mineralization, and phosphate plays a vital role in a number of other biological processes such as signal transduction, nucleotide metabolism, and enzyme regulation. The study of rare disorders associated with renal phosphate wasting has resulted in the discovery of a number of proteins [fibroblast growth factor 23 (FGF-23), secreted frizzled related protein 4 (sFRP-4), matrix extracellular phosphoglycoprotein, and FGF 7 (FGF-7)] that decrease renal sodium-dependent phosphate transport in vivo and in vitro. The "phosphatonins," FGF-23 and sFRP-4, also inhibit the synthesis of 1
,25-dihydroxyvitamin D, leading to decreased intestinal phosphate absorption and further reduction in phosphate retention by the organism. In this review, we discuss the biological properties of these proteins, alterations in their concentrations in various clinical disorders, and their possible physiological role.
phosphate; secreted frizzled related protein 4; fibroblast growth factor 23; matrix extracellular phosphoglycoprotein; vitamin D
This article has been cited by other articles:
|
|
 |
|
  L. Masi, A. Gozzini, A. Franchi, D. Campanacci, A. Amedei, A. Falchetti, F. Franceschelli, G. Marcucci, A. Tanini, R. Capanna, et al. A Novel Recessive Mutation of Fibroblast Growth Factor-23 in Tumoral Calcinosis J. Bone Joint Surg. Am., May 1, 2009; 91(5): 1190 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Berndt and R. Kumar Novel Mechanisms in the Regulation of Phosphorus Homeostasis Physiology, February 1, 2009; 24(1): 17 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Marks, L. J. Churchill, E. S. Debnam, and R. J. Unwin Matrix Extracellular Phosphoglycoprotein Inhibits Phosphate Transport J. Am. Soc. Nephrol., December 1, 2008; 19(12): 2313 - 2320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P. How, D. L. Mason, and A. H. Lau Current Approaches in the Treatment of Chronic Kidney Disease Mineral and Bone Disorder Journal of Pharmacy Practice, June 1, 2008; 21(3): 196 - 213. [Abstract] [PDF]
|
|
|
|
 |
|
 S. J. Khundmiri, A. Ahmad, R. E. Bennett, E. J. Weinman, D. Steplock, J. Cole, P. D. Baumann, J. Lewis, S. Singh, B. J. Clark, et al. Novel regulatory function for NHERF-1 in Npt2a transcription Am J Physiol Renal Physiol, April 1, 2008; 294(4): F840 - F849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Thomas and R. Kumar Control of Renal Solute Excretion by Enteric Signals and Mediators J. Am. Soc. Nephrol., February 1, 2008; 19(2): 207 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Maiti, N. C. Hait, and M. J. Beckman Extracellular Calcium-sensing Receptor Activation Induces Vitamin D Receptor Levels in Proximal Kidney HK-2G Cells by a Mechanism That Requires Phosphorylation of p38{alpha} MAPK J. Biol. Chem., January 4, 2008; 283(1): 175 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Voormolen, M. Noordzij, D. C. Grootendorst, I. Beetz, Y. W. Sijpkens, J. G. van Manen, E. W. Boeschoten, R. M. Huisman, R. T. Krediet, F. W. Dekker, et al. High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients Nephrol. Dial. Transplant., October 1, 2007; 22(10): 2909 - 2916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Fliser, B. Kollerits, U. Neyer, D. P. Ankerst, K. Lhotta, A. Lingenhel, E. Ritz, F. Kronenberg, and for the MMKD Study Group Fibroblast Growth Factor 23 (FGF23) Predicts Progression of Chronic Kidney Disease: The Mild to Moderate Kidney Disease (MMKD) Study J. Am. Soc. Nephrol., September 1, 2007; 18(9): 2600 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Six, D. Septier, C. Chaussain-Miller, R. Blacher, P. DenBesten, and M. Goldberg Dentonin, a MEPE Fragment, Initiates Pulp-healing Response to Injury Journal of Dental Research, August 1, 2007; 86(8): 780 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Canadillas, A. Rodriguez-Benot, and M. Rodriguez More on the bone-kidney axis--lessons from hypophosphataemia Nephrol. Dial. Transplant., June 1, 2007; 22(6): 1521 - 1523. [Full Text] [PDF]
|
|
|
|
 |
|
 K. U.E. Ogbureke and L. W. Fisher SIBLING Expression Patterns in Duct Epithelia Reflect the Degree of Metabolic Activity J. Histochem. Cytochem., April 1, 2007; 55(4): 403 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Guerreiro, J. L. Renfro, D. M. Power, and A. V. M. Canario The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R679 - R696. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
