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Am J Physiol Renal Physiol 290: F127-F137, 2006. First published June 7, 2005; doi:10.1152/ajprenal.00366.2004
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Zinc protects renal function during cadmium intoxication in the rat

G. Jacquillet,1 O. Barbier,1 M. Cougnon,1 M. Tauc,1 M. C. Namorado,2 D. Martin,2 J. L. Reyes,2 and P. Poujeol1

1Unité Mixte de Recherche-Centre National de la Recherche Scientifique 6548, Université de Nice-Sophia Antipolis, Nice, France; and 2Departamento de Fisiologia y Biofisica, Centro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico

Submitted 28 September 2004 ; accepted in final form 3 June 2005

This study investigates the effect in the rat of chronic CdCl2 intoxication (500 µg Cd2+/kg, daily ip injection for 5 days) on renal function and the changes in tight junction proteins claudin-2, claudin-3, and claudin-5 present in rat kidney. We also studied the effect of coadministration of ZnCl2 (500 µg Zn2+/kg) during chronic CdCl2 intoxication. Our results indicate that 1) most of the filtered Cd2+ is reabsorbed within the kidney; 2) chronic Cd2+ intoxication can induce a change in renal handling of ions without altering glomerular filtration rate; 3) a delayed nephropathy, showing Fanconi-like features, appears more than 5 days after the end of CdCl2 exposure; 4) epithelial integrity is altered by chronic Cd2+ intoxication affecting the expression and localization of claudin tight junction proteins; and 5) cotreatment with Zn2+ protects against the renal toxic effects of Cd2+, preventing altered claudin expression and inhibiting apoptosis. In conclusion, these results show that Cd2+ toxicity and cellular toxic mechanisms are complex, probably affecting both membrane transporters and tight junction proteins. Finally, Zn2+ supplementation may provide a basis for future treatments.

heavy metals; kidney; protective treatment; tight junction


Address for reprint requests and other correspondence: P. Poujeol, UMR-CNRS 6548, Bâtiment Sciences Naturelles, Université de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France (e-mail: poujeol{at}unice.fr)




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G. Jacquillet, O. Barbier, I. Rubera, M. Tauc, A. Borderie, M. C. Namorado, D. Martin, G. Sierra, J. L. Reyes, P. Poujeol, et al.
Cadmium causes delayed effects on renal function in the offspring of cadmium-contaminated pregnant female rats
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1450 - F1460.
[Abstract] [Full Text] [PDF]


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