HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (39) Citing Articles via Google Scholar Google Scholar Articles by Kirkby, K. A. Articles by Adin, C. A. Search for Related Content PubMed PubMed Citation Articles by Kirkby, K. A. Articles by Adin, C. A.

INVITED REVIEW

Products of heme oxygenase and their potential therapeutic applications

Department of Small Animal Clinical Sciences, Veterinary Medical Teaching Hospital, University of Florida, Gainesville, Florida

Heme oxygenase 1 (HO-1) is induced in response to cellular stress and is responsible for converting the prooxidant heme molecule into equimolar quantities of biliverdin (BV), carbon monoxide (CO), and iron. BV is then converted to bilirubin (BR) by the enzyme biliverdin reductase. Experimental evidence suggests that induction of the HO system is an important endogenous mechanism for cytoprotection and that the downstream products of heme degradation, CO, BR, and BV, may mediate these powerful beneficial effects. These molecules, which were once considered to be toxic metabolic waste products, have recently been shown to have dose-dependent vasodilatory, antioxidant, and anti-inflammatory properties that are particularly desirable for tissue protection during organ transplantation. In fact, recent work has demonstrated that administration of exogenous CO, BR, or BV may offer a simple, inexpensive method to substitute for the cytoprotective effects of HO-1 in a variety of clinically applicable models. This review will attempt to summarize the relevant biochemical and cytoprotective properties of CO, BR, and BV, and will discuss emerging studies involving the therapeutic applications of these molecules in the kidney and other organ systems.

bilirubin; biliverdin; carbon monoxide; ischemia-reperfusion injury

This article has been cited by other articles:

				P. Yao, L. Hao, N. Nussler, A. Lehmann, F. Song, J. Zhao, P. Neuhaus, L. Liu, and A. Nussler The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage Am J Physiol Gastrointest Liver Physiol, June 1, 2009; 296(6): G1318 - G1323. [Abstract] [Full Text] [PDF]

				S. Saleem, H. Zhuang, S. Biswal, Y. Christen, and S. Dore Ginkgo Biloba Extract Neuroprotective Action Is Dependent on Heme Oxygenase 1 in Ischemic Reperfusion Brain Injury Stroke, December 1, 2008; 39(12): 3389 - 3396. [Abstract] [Full Text] [PDF]

				C.-C. Wu, K.-C. Lu, J.-S. Chen, H.-Y. Hsieh, S.-H. Lin, P. Chu, J.-Y. Wang, H.-K. Sytwu, and Y.-F. Lin HO-1 induction ameliorates experimental murine membranous nephropathy: anti-oxidative, anti-apoptotic and immunomodulatory effects Nephrol. Dial. Transplant., October 1, 2008; 23(10): 3082 - 3090. [Abstract] [Full Text] [PDF]

				J. L. Rodford, C. Torrens, R. C. M. Siow, G. E. Mann, M. A. Hanson, and G. F. Clough Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease J. Physiol., October 1, 2008; 586(19): 4709 - 4720. [Abstract] [Full Text] [PDF]

				E. A. Herrera, R. V. Reyes, D. A. Giussani, R. A. Riquelme, E. M. Sanhueza, G. Ebensperger, P. Casanello, N. Mendez, R. Ebensperger, E. Sepulveda-Kattan, et al. Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano Cardiovasc Res, January 1, 2008; 77(1): 197 - 201. [Abstract] [Full Text] [PDF]

				M. G. Salom, S. Nieto Ceron, F. Rodriguez, B. Lopez, I. Hernandez, J. Gil Martinez, A. Martinez Losa, and F. J. Fenoy Heme oxygenase-1 induction improves ischemic renal failure: role of nitric oxide and peroxynitrite Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3542 - H3549. [Abstract] [Full Text] [PDF]

				A. Zimmermann, C. W. Leffler, D. Tcheranova, A. L. Fedinec, and H. Parfenova Cerebroprotective effects of the CO-releasing molecule CORM-A1 against seizure-induced neonatal vascular injury Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2501 - H2507. [Abstract] [Full Text] [PDF]

				J. Wang and S. Dore Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage Brain, June 1, 2007; 130(6): 1643 - 1652. [Abstract] [Full Text] [PDF]

				S. Villanueva, C. Cespedes, A. A. Gonzalez, C. P. Vio, and V. Velarde Effect of ischemic acute renal damage on the expression of COX-2 and oxidative stress-related elements in rat kidney Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1364 - F1371. [Abstract] [Full Text] [PDF]

				S. W. Ryter, D. Morse, and A. M. K. Choi Carbon Monoxide and Bilirubin: Potential Therapies for Pulmonary/Vascular Injury and Disease Am. J. Respir. Cell Mol. Biol., February 1, 2007; 36(2): 175 - 182. [Abstract] [Full Text] [PDF]