| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
INVITED REVIEW
Departments of Medicine and Cell Biology, University of Alabama at Birmingham, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama
The epithelial tight junction (TJ) is responsible for the control of paracellular transport between epithelial cells (gate function) and the maintenance of apical/basolateral polarity by preventing the diffusion of membrane lipids and/or proteins from one surface domain to another (fence function). Renal tubule epithelia in the mammalian nephron have TJs that determine paracellular transport characteristics. Paracellular transport across renal tubular epithelial TJs (gate function) varies in different segments of the nephron. A large family of recently identified TJ-associated transmembrane proteins named claudins appear to determine the paracellular permeability properties of the TJ. A combination of inherited human diseases, renal epithelial cell culture models, and nephron expression patterns of claudins is providing important clues about how claudin molecules determine the TJ gate function of renal epithelia in different segments of the nephron.
transport; regulation; polarity
This article has been cited by other articles:
|
|
 |
|
  D. F. Balkovetz, P. Chumley, and H. Amlal Downregulation of claudin-2 expression in renal epithelial cells by metabolic acidosis Am J Physiol Renal Physiol, September 1, 2009; 297(3): F604 - F611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Harten, D. Shukla, R. Barod, A. Hergovich, M. S. Balda, K. Matter, M. A. Esteban, and P. H. Maxwell Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin Mol. Biol. Cell, February 1, 2009; 20(3): 1089 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Alexander, J. G. Hoenderop, and R. J. Bindels Molecular Determinants of Magnesium Homeostasis: Insights from Human Disease J. Am. Soc. Nephrol., August 1, 2008; 19(8): 1451 - 1458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bagherie-Lachidan, S. I. Wright, and S. P. Kelly Claudin-3 tight junction proteins in Tetraodon nigroviridis: cloning, tissue-specific expression, and a role in hydromineral balance Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1638 - R1647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lechner, N. A. Malloth, P. Jennings, D. Heckl, W. Pfaller, and T. Seppi Opposing roles of EGF in IFN-{alpha}-induced epithelial barrier destabilization and tissue repair Am J Physiol Cell Physiol, December 1, 2007; 293(6): C1843 - C1850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kalujnaia, I. S. McWilliam, V. A. Zaguinaiko, A. L. Feilen, J. Nicholson, N. Hazon, C. P. Cutler, and G. Cramb Transcriptomic approach to the study of osmoregulation in the European eel Anguilla anguilla Physiol Genomics, November 14, 2007; 31(3): 385 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Singh, K. Sugimoto, P. Dhawan, and R. C. Harris Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1660 - C1668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Balkovetz Opening Pandora's Box in the Tight Junction J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1624 - 1625. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Arabzadeh, T.-C. Troy, and K. Turksen Role of the Cldn6 Cytoplasmic Tail Domain in Membrane Targeting and Epidermal Differentiation In Vivo Mol. Cell. Biol., August 1, 2006; 26(15): 5876 - 5887. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
