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Am J Physiol Renal Physiol 290: F975-F984, 2006; doi:10.1152/ajprenal.00336.2005
0363-6127/06 $8.00
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INVITED REVIEW

PTH(1–84)/PTH(7–84): a balance of power

Peter A. Friedman1 and William G. Goodman2

1Departments of Pharmacology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, and Institut für Pharmakologie und Toxikologie, Julius Maximillians Universität Würzburg, Würzburg, Germany; and 2Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, California

This review considers many new basic and clinical aspects of parathyroid hormone (PTH). We focus especially on the identification of PTH fragments and how they may relate to renal failure, diagnosis, and treatment of secondary hyperparathyroidism and renal osteodystrophy. The biosynthesis and metabolism of PTH, measurement of circulating forms of PTH, the effects of PTH on receptor activation and turnover, the relationship between PTH levels and bone turnover in renal failure in humans, and the involvement of PTH in experimental models of renal failure are discussed. Despite these developments in understanding the etiology of renal failure and the availability of new assays for bioactive PTH, no adequate surrogate for bone biopsy and quantitative bone histomorphometry has been developed.

peptide fragments; hormone resistance; receptor downregulation; immunometric assay; renal osteodystrophy


Address for reprint requests and other correspondence: P. A. Friedman, Univ. of Pittsburgh School of Medicine, Dept. of Pharmacology, E-1347 Biomedical Science Tower, Pittsburgh, PA 15261 (e-mail: paf10{at}pitt.edu)




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A. J. Felsenfeld, M. Rodriguez, and E. Aguilera-Tejero
Dynamics of Parathyroid Hormone Secretion in Health and Secondary Hyperparathyroidism
Clin. J. Am. Soc. Nephrol., November 1, 2007; 2(6): 1283 - 1305.
[Abstract] [Full Text] [PDF]


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